■在过去的几十年里,越来越多的人关注自闭症谱系障碍(ASD)患病率增加和精子质量下降的同时趋势.这些趋势代表了重大的公共卫生挑战,需要对其根本原因和影响进行彻底调查。
■这项研究的主要目标是分析2000年至2024年ASD患病率和精子质量参数的趋势,评估这些趋势的统计意义和影响大小,探索ASD患病率与精子质量参数之间的潜在相关性,并确定影响ASD患病率的精子质量参数中的重要预测因子。
■这项研究采用了使用多元回归的纵向方法,时间序列分析,方差分析,主成分分析(PCA),分层聚类,逻辑回归,和互相关分析。ASD患病率的数据来自CDC自闭症和发育障碍监测网络,而精子质量数据是从各种已发表的研究中收集的。
■研究结果表明,ASD患病率与精子质量参数(如精子浓度和活力)之间存在显著的负相关,这表明更好的精子质量与更低的ASD率有关。相反,参数,如精子DNA片段(SDF),射精量,pH值,精液粘度与ASD患病率呈正相关,表明这些参数中较高的值与较高的ASD率相关。
该研究强调了维持生殖健康对潜在减轻ASD风险的重要性,并呼吁进一步研究以阐明驱动这些趋势的潜在机制。这些发现支持生殖健康因素在ASD病因中起关键作用的假设,并提出了评估ASD风险的潜在生物学标记。
UNASSIGNED: Over the past few decades, there has been growing concern about the concurrent trends of increasing Autism Spectrum Disorder (ASD) prevalence and declining sperm quality. These trends represent significant public health challenges that warrant thorough investigation of their underlying causes and implications.
UNASSIGNED: The primary objectives of this study are to analyze trends in ASD prevalence and sperm quality parameters from 2000 to 2024, assess the statistical significance and effect size of these trends, explore potential correlations between ASD prevalence and sperm quality parameters, and identify significant predictors among sperm quality parameters that influence ASD prevalence.
UNASSIGNED: This study employed a longitudinal approach using multiple regression, time series analysis, ANOVA, Principal Component Analysis (PCA), hierarchical clustering, logistic regression, and cross-correlation analysis. Data on ASD prevalence were sourced from the CDC Autism and Developmental Disabilities Monitoring Network, while sperm quality data were collected from various published studies.
UNASSIGNED: The findings reveal significant negative associations between ASD prevalence and sperm quality parameters such as sperm concentration and motility, suggesting that better sperm quality is linked to lower ASD rates. Conversely, parameters like sperm DNA fragmentation (SDF), volume of ejaculate, pH level, and semen viscosity show positive associations with ASD prevalence, indicating higher values in these parameters correlate with higher ASD rates.
UNASSIGNED: The study highlights the importance of maintaining reproductive health to potentially mitigate ASD risk and calls for further research to elucidate the underlying mechanisms driving these trends. These findings support the hypothesis that reproductive health factors play a crucial role in ASD etiology and suggest potential biological markers for assessing ASD risk.