■血管肉瘤,一种罕见的内皮源性肿瘤,可以在全身发育,头部和颈部皮肤是最常见的受影响的区域。它也可以起源于其他部位,如乳房,髂动脉,包括肝脏在内的内脏器官,脾,脾还有肾脏.骨的血管肉瘤非常罕见,表现为单灶性或多灶性骨病变,通常导致严峻的预后。诊断骨血管肉瘤提出了重大挑战。18F-FDGPET/CT是评估远处转移和临床分期血管肉瘤的可靠且不可或缺的成像方式。
■一名57岁的女性,有10天的头晕和头痛病史。头颅CT扫描显示顶骨骨破坏,伴有软组织损伤,突出到硬膜外腔.MRI检查显示T2FLAIR上的病变信号强度略有升高,显示适度增强。此外,在T12,L1-5和S1-2椎骨内观察到多个病灶,以及双侧髂骨。对于分期,进行18F-FDGPET/CT。MIPPET显示胸骨多灶性FDG-vid病变,双侧锁骨,双侧肩胛骨,多根肋骨,和骨盆骨。在多个骨病变中观察到FDG摄取不均,包括颅内(SUVmax=11.3),T10椎骨的右横突(SUVmax=5.8),髂骨(SUVmax=3.3),和耻骨(SUVmax=4.7)。患者接受了颅骨病变的手术切除。病理诊断为高分化血管肉瘤。
■骨血管肉瘤在FDGPET/CT扫描上表现为异常的FDG摄取和溶骨破坏。该病例强调骨血管肉瘤可表现为多中心FDG摄取,类似于多发性骨髓瘤的模式。FDGPET/CT可以作为对这种罕见的恶性肿瘤进行分期的有用工具,提供潜在的引导活检程序到最代谢活跃的部位。在鉴别诊断多发性溶骨性病变时应考虑,包括转移癌,多发性骨髓瘤,和骨淋巴瘤。
UNASSIGNED: Angiosarcoma, a rare endothelial-origin tumor, can develop throughout the body, with the head and neck skin being the most commonly affected areas. It can also originate in other sites such as the breast, iliac artery, and visceral organs including the liver, spleen, and kidneys.
Angiosarcoma of the bone is remarkably rare, presenting as either unifocal or multifocal bone lesions and often leading to a grim prognosis. Diagnosing bone angiosarcoma poses a significant challenge. 18F-FDG PET/CT serves as a reliable and indispensable imaging modality for evaluating distant metastases and clinically staging angiosarcomas.
UNASSIGNED: A 57-year-old woman presented with a 10-day history of dizziness and headaches. Cranial CT scan revealed bone destruction of the parietal bone, accompanied by soft tissue lesions, protruding into the epidural space. MRI examination demonstrated lesions with slightly elevated signal intensity on T2FLAIR, showing moderate enhancement. Furthermore, multiple foci were observed within the T12, L1-5, and S1-2 vertebrae, as well as in the bilateral iliac bones. For staging, 18F-FDG PET/CT was performed. The MIP PET showed multifocal FDG-avid lesions in the sternum, bilateral clavicles, bilateral scapulae, multiple ribs, and pelvic bones. Heterogeneous FDG uptake was observed in multiple bone lesions, including intracranial (SUVmax = 11.3), right transverse process of the T10 vertebra (SUVmax = 5.8), ilium (SUVmax = 3.3), and pubis (SUVmax = 4.7). The patient underwent surgical resection of the cranial lesion. The pathological diagnosis was made with a highly differentiated
angiosarcoma.
UNASSIGNED: Angiosarcoma of bone on FDG PET/CT scans is characterized by abnormal FDG uptake along with osteolytic destruction. This case highlights that
angiosarcoma of bone can manifest as multicentric FDG uptake, resembling the pattern seen in multiple myeloma. FDG PET/CT can be a useful tool for staging this rare malignant tumor, offering the potential to guide biopsy procedures toward the most metabolically active site. And it should be considered in the differential diagnosis of multiple osteolytic lesions, including metastatic carcinoma, multiple myeloma, and lymphoma of bone.