■虽然儿童过敏性疾病呈上升趋势,在中国中部地区,尚未对影响过敏性疾病儿童的过敏原进行全面调查。因此,我们旨在分析中国中部地区过敏性疾病儿童的血清过敏原种类分布,以指导预防,诊断,和治疗儿童过敏。
■共有9213名儿童(5543名男性,2.88±0.04岁,3670名女性,2.91±0.05岁)接受了过敏原筛查,使用自动荧光酶免疫测定系统检测血清过敏原特异性IgE(sIgE)抗体。
■我们的发现显示sIgE阳性率(sIgE-PR)为57.83%,混合食物(42.10%),蛋白(30.83%),牛奶(28.97%),混合尘螨(24.57%),和混合霉菌(23.20%)是最普遍的过敏原来源。常见过敏原来源的sIgE-PR表现出显著的性别差异,男性的易感性高于女性(p<0.05)。尘螨是吸入性过敏原的主要来源,而蛋清是食物过敏原的主要来源。食物过敏原来源在婴儿(0-3岁)中占主导地位;大多数食物过敏原来源的sIgE-PRs随年龄增长而减少,而那些大多数来源的吸入性过敏原增加。秋季sIgE-PRs用于混合霉菌,杂草花粉组合,和树木花粉组合显著高于其他季节(p<0.05)。
我们的研究结果表明,过敏儿童的过敏原来源因年龄组和季节而异。了解这些模式可以提高儿童过敏的有效预防。
UNASSIGNED: Although allergic diseases in children are on the rise, there has been no comprehensive investigation of the allergens affecting children with allergic diseases in central
China. Therefore, we aimed to analyze the distribution of serum allergen species among children with allergic conditions in central
China to inform the prevention, diagnosis, and treatment of childhood allergies.
UNASSIGNED: A total of 9213 children (5543 males with 2.88 ± 0.04 years old and 3670 females with 2.91 ± 0.05 years old) underwent allergen screening, and serum allergen-specific IgE (sIgE) antibodies were detected using an automated fluorescent enzyme immunoassay system.
UNASSIGNED: Our findings revealed a total sIgE-positive rate (sIgE-PR) of 57.83%, with mixed food (42.10%), egg whites (30.83%), milk (28.97%), mixed dust mites (24.57%), and mixed molds (23.20%) being the most prevalent source of allergens. The sIgE-PR for common sources of allergens exhibited significant sex-based differences, with males having greater susceptibility than females (p<0.05). Dust mites were the primary source of inhaled allergens, whereas egg white was the predominant source of food allergens. Sources of food allergens were most dominant among infants (0-3 years old); sIgE-PRs for most source of food allergens decreased with age, whereas those for most source of inhaled allergens increased. The autumn sIgE-PRs for mixed molds, weed pollen combinations, and tree pollen combinations were significantly higher than those found in other seasons (p<0.05).
UNASSIGNED: Our findings suggest that sources of allergens profiles in children with allergies vary across age groups and seasons. Understanding these patterns can improve the effective prevention of childhood allergies.