PDF(Pubmed)
Abstract：
UNASSIGNED: With an increasing number of Clinical Practice Guidelines (CPGs) addressing primary prevention of food allergy and atopic dermatitis, it is timely to undertake a comprehensive assessment of the quality and consistency of recommendations and evaluation of their implementability in different geographical settings.
UNASSIGNED: We systematically reviewed CPGs from 8 international databases and extensive website searches. Seven reviewers screened records in any language and then used the AGREE II and AGREE REX instruments to critically appraise CPGs published between January 2011 and April 2022.
UNASSIGNED: Our search identified 2138 relevant articles, of which 30 CPGs were eventually included. Eight (27%) CPGs were shortlisted based on our predefined quality criteria of achieving scores >70% in the \"Scope and Purpose\" and \"Rigour of Development\" domains of the AGREE II instrument. Among the shortlisted CPGs, scores on the \"Applicability\" domain were generally low, and only 3 CPGs rated highly in the \"Implementability\" domain of AGREE-REX, suggesting that the majority of CPGs fared poorly on global applicability. Recommendations on maternal diet and complementary feeding in infants were mostly consistent, but recommendations on use of hydrolysed formula and supplements varied considerably.
UNASSIGNED: The overall quality of a CPG for Food Allergy and Atopic Dermatitis prevention did not correlate well with its global applicability. It is imperative that CPG developers consider stakeholders\' preferences, local applicability, and adapt existing recommendations to each individual population and healthcare system to ensure successful implementation. There is a need for development of high-quality CPGs for allergy prevention outside of North America and Europe.
UNASSIGNED: CRD42021265689.
UNASSIGNED: We systematically reviewed CPGs from 8 international databases and extensive website searches. Seven reviewers screened records in any language and then used the AGREE II and AGREE REX instruments to critically appraise CPGs published between January 2011 and April 2022.
UNASSIGNED: Our search identified 2138 relevant articles, of which 30 CPGs were eventually included. Eight (27%) CPGs were shortlisted based on our predefined quality criteria of achieving scores >70% in the \"Scope and Purpose\" and \"Rigour of Development\" domains of the AGREE II instrument. Among the shortlisted CPGs, scores on the \"Applicability\" domain were generally low, and only 3 CPGs rated highly in the \"Implementability\" domain of AGREE-REX, suggesting that the majority of CPGs fared poorly on global applicability. Recommendations on maternal diet and complementary feeding in infants were mostly consistent, but recommendations on use of hydrolysed formula and supplements varied considerably.
UNASSIGNED: The overall quality of a CPG for Food Allergy and Atopic Dermatitis prevention did not correlate well with its global applicability. It is imperative that CPG developers consider stakeholders\' preferences, local applicability, and adapt existing recommendations to each individual population and healthcare system to ensure successful implementation. There is a need for development of high-quality CPGs for allergy prevention outside of North America and Europe.
UNASSIGNED: CRD42021265689.
摘要：
■随着越来越多的针对食物过敏和特应性皮炎一级预防的临床实践指南（CPG），现在应该对建议的质量和一致性进行全面评估，并评估其在不同地理位置的可实施性。
■我们系统地审查了来自8个国际数据库和大量网站搜索的CPG。七名审稿人以任何语言筛选了记录，然后使用AGREEII和AGREEREX工具对2011年1月至2022年4月之间发布的CPG进行了批判性评估。
■我们的搜索确定了2138条相关文章，其中最终包括30个CPG。根据我们预定义的质量标准，在AGREEII工具的“范围和目的”和“发展的严谨”领域中获得分数>70％的分数，有8个（27％）CPG入围。在入围的CPG中，“适用性”领域的分数普遍较低，只有3个CPG在AGREE-REX的“可实施性”领域中获得了很高的评价，这表明大多数CPG在全球适用性方面表现不佳。关于产妇饮食和婴儿补充喂养的建议大部分是一致的，但是关于使用水解配方和补充剂的建议差异很大。
■用于食物过敏和特应性皮炎预防的CPG的总体质量与其全球适用性没有很好的相关性。CPG开发人员必须考虑利益相关者的偏好，局部适用性，并使现有建议适应每个人群和医疗保健系统，以确保成功实施。在北美和欧洲以外，需要开发高质量的CPG来预防过敏。
■CRD42021265689。
■我们系统地审查了来自8个国际数据库和大量网站搜索的CPG。七名审稿人以任何语言筛选了记录，然后使用AGREEII和AGREEREX工具对2011年1月至2022年4月之间发布的CPG进行了批判性评估。
■我们的搜索确定了2138条相关文章，其中最终包括30个CPG。根据我们预定义的质量标准，在AGREEII工具的“范围和目的”和“发展的严谨”领域中获得分数>70％的分数，有8个（27％）CPG入围。在入围的CPG中，“适用性”领域的分数普遍较低，只有3个CPG在AGREE-REX的“可实施性”领域中获得了很高的评价，这表明大多数CPG在全球适用性方面表现不佳。关于产妇饮食和婴儿补充喂养的建议大部分是一致的，但是关于使用水解配方和补充剂的建议差异很大。
■用于食物过敏和特应性皮炎预防的CPG的总体质量与其全球适用性没有很好的相关性。CPG开发人员必须考虑利益相关者的偏好，局部适用性，并使现有建议适应每个人群和医疗保健系统，以确保成功实施。在北美和欧洲以外，需要开发高质量的CPG来预防过敏。
■CRD42021265689。
