vesiculobullous

泡状
  • 文章类型: Journal Article
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  • 文章类型: Case Reports
    血管肉瘤样卡波西肉瘤代表了最近描绘的卡波西肉瘤的罕见组织形态变异,可能难以与其他血管增生性病变区分开。卡波西肉瘤的常规病变包括斑块,斑块,和结节;然而,很少有膀胱泡状病变被描述。血管肉瘤样卡波西肉瘤以前从未被报道过伴有膀胱小叶病变。在这里,我们描述了一例播散性血管肉瘤样Kaposi肉瘤的独特病例,并以囊泡状病变为人类免疫缺陷病毒感染的初始表现.
    Angiosarcoma-like Kaposi sarcoma represents a recently delineated rare histomorphologic variant of Kaposi sarcoma that can be difficult to distinguish from other vasoproliferative lesions. Conventional lesions of Kaposi sarcoma encompass patches, plaques, and nodules; however, rarely vesiculobullous lesions have been described. Angiosarcoma-like Kaposi sarcoma has never been previously reported to present with vesiculobullous lesions. Herein, we describe a unique case of disseminated angiosarcoma-like Kaposi sarcoma with vesiculobullous lesions as the initial manifestation of human immunodeficiency virus infection.
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  • 文章类型: Journal Article
    定量评估学术工作的一种众所周知的方法是文献计量分析。最佳引用的论文提高了人们对特定主题文献中有影响力的出版物和模式的认识。目的是进行文献计量学分析,以确定大多数被引用的关于囊泡状口腔病变的文章。这是对囊泡状口腔病变的引文分析的第一项研究。
    2022年12月使用Scopus数据库探索了回顾性数据搜索。文章进行了评估,并对文献计量分析的基本数据进行了综述。关于作者的标准细节,链接组织,出版年,并注明了原产地。使用卡方分析进行统计学分析。使用VOSviewer软件确定合著者和常用关键词之间共现的文献计量网络分析。
    该研究共纳入了1971年至2022年发表的344篇文章。共观察到每篇文章的6680次引用和19.41次引用。《皮肤病学档案》杂志获得的引用最多。引用次数与期刊类型之间存在显著关联(开放获取与非开放通道)(P<0.05)。在同现网络分析过程中,在VOSviewer软件的帮助下发现了四到五个高度相关的集群。
    本研究中详细列出了引用次数最多的10篇关于囊性口腔病变的文章。这将是学者们的宝贵资源,临床医生,和皮肤病学领域的研究人员,一般病理学,口腔病理学,和口服药物。
    UNASSIGNED: A well-known method for quantitatively evaluating scholarly work is bibliometric analysis. Best-cited papers raise awareness of the influential publications and patterns in the literature on a specific subject. The aim was to conduct bibliometric analysis to determine most cited articles on vesiculobullous oral lesions. This is the first study on citation analysis with respect to vesiculobullous oral lesions.
    UNASSIGNED: A retrospective data search was explored on December 2022 using the Scopus database. The articles were evaluated, and fundamental data for bibliometric analysis was reviewed. Standard details about the author, linked organizations, publishing year, and place of origin were noted. Statistical analysis was performed using Chi-square analysis. VOSviewer software was used to determine the bibliometric network analysis for co-occurrence among coauthors and commonly used keywords.
    UNASSIGNED: A total of 344 articles published from 1971 to 2022 were included in the study. A total of 6680 citations and 19.41 citations per article were observed. The journal Archives of Dermatology received the most citation. There was a significant association between the number of citations and the journal type (open access vs. non-open access) (P < 0.05). Four to five highly related clusters with the help of VOSviewer software were found during co-occurrence network analysis.
    UNASSIGNED: The top 10 articles on vesiculobullous oral lesions that received the most citations were listed in detail in the present study. This will be a valuable resource for academics, clinicians, and researchers in the fields of dermatology, general pathology, oral pathology, and oral medicine.
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  • 文章类型: Case Reports
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  • 文章类型: Journal Article
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  • 文章类型: Journal Article
    囊性皮损是一组主要由免疫介导的皮肤粘膜病变,但也可能具有遗传或病毒起源。最常见的发生部位是颊粘膜,而涉及牙龈的病例数量相对较低。根据文献,尽管许多研究报道了非角化上皮中膀胱泡状病变的患病率,对其在角化口腔粘膜中的发生缺乏了解,尤其是牙龈.该研究的目的是评估免疫介导的口腔囊泡状病变的患病率,强调角化粘膜的发生,尤其是牙龈,在私人牙科医院就诊的患者中。
    这项研究是在一家私立牙科教学机构和医院环境中进行的。在口腔病理科接受的615例切开活检中,在2019年6月至2021年4月期间,n=22个样本为免疫介导的囊泡囊性病变,在消除病毒来源的病变后,经临床和组织病理学诊断证实.患者详细信息,包括年龄,性别,site,持续时间,从数字信息存档软件中收集系统性疾病,并使用SPSS软件进行适当的统计学分析.
    根据结果,95.5%的患者具有上皮内裂开的组织病理学特征,只有4.5%的患者表现为上皮下裂开。女性好发指数为6.3:1。最常见的受累部位是非角化粘膜(36.36%),59.09%的患者出现全身性疾病。
    研究表明,天疱疮的大多数特征在牙龈和口腔粘膜的其他部位是一致的。牙科医生应了解此类病变的各种口腔表现,以确保准确诊断和适当治疗。
    UNASSIGNED: Vesiculobullous lesions are a group of mucocutaneous lesions that are predominantly immune-mediated but may also have a genetic or viral origin. The most common site of occurrence is buccal mucosa, whereas the number of cases involving gingiva is comparatively low. Based on the literature, although numerous studies have reported the prevalence of vesiculobullous lesions in the nonkeratinized epithelium, there is a dearth of knowledge about its occurrence in keratinized oral mucosa, especially gingiva. The objective of the study was to assess the prevalence of immune-mediated oral vesiculobullous lesions emphasizing the occurrence in keratinized mucosa, especially the gingiva, among patients visiting a private dental hospital.
    UNASSIGNED: The study was conducted in a private teaching dental institute and hospital setting. Out of 615 incisional biopsies received in the department of oral pathology, between June 2019 and April 2021, n = 22 samples were immune-mediated vesiculobullous lesions confirmed by clinical and histopathological diagnosis after eliminating lesions of viral origin. Patient details including age, gender, site, duration, and systemic illness were collected from the digital information archiving software and analyzed by appropriate statistics using SPSS software.
    UNASSIGNED: Based on the results, 95.5% of the patients had histopathological features of intraepithelial clefting and only 4.5% of them showed subepithelial clefting. Female predilection was 6.3:1. The most common site of involvement was nonkeratinized mucosa (36.36%) and 59.09% of the patients presented with systemic illness.
    UNASSIGNED: The study shows most of the features of pemphigus is consistent in gingiva and other parts of oral mucosa. The dental practitioners should be aware of the various oral manifestations of such lesions to ensure accurate diagnosis and adequate treatment.
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  • 文章类型: Journal Article
    足癣是皮肤最常见的浅表真菌感染之一,临床表现多样。这篇综述旨在使医生熟悉临床特征,足癣的诊断和治疗。
    2023年4月,在PubMed临床查询中使用关键术语“足癣”或“运动员脚”进行了搜索。搜索策略包括所有临床试验,在过去的10年中,以英语发表的观察性研究和评论。
    足癣最常见的是红色毛癣菌和毛癣菌。据估计,大约3%的世界人口患有足癣。青少年和成人的患病率高于儿童。高峰年龄发病率在16至45岁之间。足癣在男性中比女性更常见。家庭成员之间的传播是最常见的途径,和传播也可以通过间接接触受影响患者的受污染物品而发生。公认的足癣的三种主要临床形式:指间,角化过度(莫卡辛型)和囊泡(炎性)。足癣的临床诊断准确率较低。建议对病变活动边界的皮肤刮片进行KOH湿装检查,作为护理点测试。诊断是可以确认的,如有必要,通过真菌培养或不依赖于培养的分子工具进行皮肤刮片。浅表或局部足癣通常对局部抗真菌治疗有反应。口服抗真菌治疗应保留用于严重疾病,局部抗真菌治疗失败,同时存在甲癣或免疫功能低下的患者。
    局部抗真菌治疗(每天一次至两次,持续1-6周)是治疗浅表或局部足癣的主要方法。局部抗真菌剂的例子包括烯丙基胺(例如特比萘芬),唑类(如酮康唑),苄胺,环吡酮,Tolnaftate和amorolfine.用于治疗足癣的口服抗真菌药包括特比萘芬,伊曲康唑和氟康唑。局部和口服抗真菌药物联合治疗可提高治愈率。通过适当的抗真菌治疗预后良好。未治疗,病变可能持续并进展。
    UNASSIGNED: Tinea pedis is one of the most common superficial fungal infections of the skin, with various clinical manifestations. This review aims to familiarize physicians with the clinical features, diagnosis and management of tinea pedis.
    UNASSIGNED: A search was conducted in April 2023 in PubMed Clinical Queries using the key terms \'tinea pedis\' OR \'athlete\'s foot\'. The search strategy included all clinical trials, observational studies and reviews published in English within the past 10 years.
    UNASSIGNED: Tinea pedis is most often caused by Trichophyton rubrum and Trichophyton interdigitale. It is estimated that approximately 3% of the world population have tinea pedis. The prevalence is higher in adolescents and adults than in children. The peak age incidence is between 16 and 45 years of age. Tinea pedis is more common amongst males than females. Transmission amongst family members is the most common route, and transmission can also occur through indirect contact with contaminated belongings of the affected patient. Three main clinical forms of tinea pedis are recognized: interdigital, hyperkeratotic (moccasin-type) and vesiculobullous (inflammatory). The accuracy of clinical diagnosis of tinea pedis is low. A KOH wet-mount examination of skin scrapings of the active border of the lesion is recommended as a point-of-care testing. The diagnosis can be confirmed, if necessary, by fungal culture or culture-independent molecular tools of skin scrapings. Superficial or localized tinea pedis usually responds to topical antifungal therapy. Oral antifungal therapy should be reserved for severe disease, failed topical antifungal therapy, concomitant presence of onychomycosis or in immunocompromised patients.
    UNASSIGNED: Topical antifungal therapy (once to twice daily for 1-6 weeks) is the mainstay of treatment for superficial or localized tinea pedis. Examples of topical antifungal agents include allylamines (e.g. terbinafine), azoles (e.g. ketoconazole), benzylamine, ciclopirox, tolnaftate and amorolfine. Oral antifungal agents used for the treatment of tinea pedis include terbinafine, itraconazole and fluconazole. Combined therapy with topical and oral antifungals may increase the cure rate. The prognosis is good with appropriate antifungal treatment. Untreated, the lesions may persist and progress.
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  • 文章类型: Journal Article
    寻常型天疱疮是一种自身免疫性膀胱囊性粘膜皮肤疾病,具有危及生命的后果。早期发现和适当的护理对于良好的预后至关重要。本研究旨在确定人口统计数据,临床特征,以及口服寻常型天疱疮患者的预后。
    从2001年到2021年,提取了所有诊断为口腔寻常型天疱疮的病例。收集每位患者的人口统计学和临床数据。患者通过电话评估预后,治疗类型,以及提供诊断和治疗的医生的专长。
    大多数患者只有口腔病变,女性的患病率也比男性高。29名患者中只有14名回复了电话。除了一个,所有患者均为活动性疾病。超过一半的受访者表示,天疱疮会对社会行为和食物摄入产生负面影响。正确的诊断和治疗由皮肤科决定,口服药物,和颌面外科专家。
    口服寻常型天疱疮在女性中普遍存在。严重疼痛常见于女性和老年人。即使有有效的治疗,预后较差。医疗和牙科专业人员对寻常型天疱疮知之甚少。患者经常报告生活质量差。
    UNASSIGNED: Pemphigus vulgaris is an autoimmune vesiculobullous mucocutaneous disorder with life-threatening consequences. Early detection and adequate care are crucial for a good prognosis. This study aimed to determine the demographic data, clinical features, and the prognosis of patients with oral pemphigus vulgaris.
    UNASSIGNED: From 2001 to 2021, all diagnosed oral pemphigus vulgaris cases were extracted. Each patient\'s demographic and clinical data were gathered. Patients were called via phone to assess the prognosis, treatment type, and specialty of the physician who provided the diagnosis and therapy.
    UNASSIGNED: The majority of the patients had only oral lesions with higher prevalence in female who also expressed severe pain than male. Only 14 of 29 patients responded phone calls. Except for one, all patients were in active disease. More than half of those respondents said pemphigus negatively affects social behavior and food intake. Correct diagnosis and treatment were decided by dermatology, oral medicine, and maxillofacial surgery specialists.
    UNASSIGNED: Oral pemphigus vulgaris was prevalent in females. Severe pain was common in females and older people. Even with effective therapy, the prognosis was poor. Medical and dental professionals had little knowledge of pemphigus vulgaris. Patients frequently report poor quality of life.
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  • 文章类型: Journal Article
    大疱性系统性红斑狼疮(BSLE)是系统性红斑狼疮(SLE)的一种罕见亚型,其临床特征是表皮下紧张的囊泡或大疱性。我们旨在探讨BSLE患者的临床和实验室特征。
    我们回顾性回顾了2015年至2021年在我们机构中符合BSLE诊断标准的所有患者。皮肤损伤,系统性表现,治疗方案,并对结果进行了评估。对于BSLE的每种情况,从单发SLE患者中随机选择4名对照.比较两组患者的主要临床及实验室特征。
    在4221例SLE患者中,12开发的BSLE。BSLE患者中有5例(5/12,41.7%)是首次出现,其余7例(7/12,58.3%)在SLE诊断后出现,从SLE开始的中位持续时间为36个月(4-115个月)。最常见的BSLE感染部位是头颈部(10/12,83.3%),四肢(9/12,75.0%),树干(7/12,58.3%),粘膜(6/12,50.0%)。所有BSLE患者均有皮肤外受累。10/12(83.3%)患者SLE疾病活动指数得分超过5分,这表明疾病活动性高。BSLE组患者的蛋白尿发生率明显较高(83.3%vs.47.9%,P=0.027),血尿(75%vs.31.3%,P=0.006),溶血性贫血(33.3%vs.0%,P=0.000),和白细胞减少(66.7%vs.25.0%,P=0.006)比对照组高。全身性皮质类固醇的使用,免疫抑制剂,氨苯砜,皮肤护理在控制疾病方面是有效的。
    囊泡状病变可能是BSLE患者的第一表现,表明疾病活动性高。早期诊断使用临床,组织病理学,和免疫学评估可以导致这种进行性疾病的适当治疗并改善预后。
    Bullous systemic lupus erythematosus (BSLE) is a rare subtype of systemic lupus erythematosus (SLE) that is clinically characterized by subepidermal tense vesicles or bullae. We aimed to investigate the clinical and laboratory features of patients with BSLE.
    We retrospectively reviewed all patients who fulfilled the diagnostic criteria for BSLE in our institution from 2015 to 2021. Cutaneous lesions, systemic manifestations, treatment options, and outcomes were evaluated. For each case of BSLE, four controls were randomly selected from patients with single SLE. Major clinical and laboratory characteristics were compared between the two groups.
    Among 4221 patients with SLE, 12 developed BSLE. Vesiculobullous lesions were the first sign in five of the BSLE patients (5/12, 41.7%) and appeared after SLE diagnosis in the remaining seven patients (7/12, 58.3%), with a median duration from SLE onset of 36 months (4-115 months). The most common BSLE-affected sites were the head and neck (10/12, 83.3%), extremities (9/12, 75.0%), trunk (7/12, 58.3%), and mucosae (6/12, 50.0%). All patients with BSLE had extra-cutaneous involvement. The SLE disease activity index score exceeded 5 in 10/12 (83.3%) patients, which indicated high disease activity. Patients in the BSLE group had significantly higher incidences of proteinuria (83.3% vs. 47.9%, P = 0.027), hematuria (75% vs. 31.3%, P = 0.006), hemolytic anemia (33.3% vs. 0%, P = 0.000), and leukopenia (66.7% vs. 25.0%, P = 0.006) than those in the control group. The use of systemic corticosteroids, immunosuppressants, dapsone, and skin care was effective in controlling disease.
    Vesiculobullous lesions may be the first manifestation and indicate a high disease activity in patients with BSLE. Early diagnosis using clinical, histopathological, and immunological evaluations can lead to appropriate treatment of this progressive disease and improve prognosis.
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