PDF(Pubmed)
Abstract：
UNASSIGNED: Vesiculobullous lesions are a group of mucocutaneous lesions that are predominantly immune-mediated but may also have a genetic or viral origin. The most common site of occurrence is buccal mucosa, whereas the number of cases involving gingiva is comparatively low. Based on the literature, although numerous studies have reported the prevalence of vesiculobullous lesions in the nonkeratinized epithelium, there is a dearth of knowledge about its occurrence in keratinized oral mucosa, especially gingiva. The objective of the study was to assess the prevalence of immune-mediated oral vesiculobullous lesions emphasizing the occurrence in keratinized mucosa, especially the gingiva, among patients visiting a private dental hospital.
UNASSIGNED: The study was conducted in a private teaching dental institute and hospital setting. Out of 615 incisional biopsies received in the department of oral pathology, between June 2019 and April 2021, n = 22 samples were immune-mediated vesiculobullous lesions confirmed by clinical and histopathological diagnosis after eliminating lesions of viral origin. Patient details including age, gender, site, duration, and systemic illness were collected from the digital information archiving software and analyzed by appropriate statistics using SPSS software.
UNASSIGNED: Based on the results, 95.5% of the patients had histopathological features of intraepithelial clefting and only 4.5% of them showed subepithelial clefting. Female predilection was 6.3:1. The most common site of involvement was nonkeratinized mucosa (36.36%) and 59.09% of the patients presented with systemic illness.
UNASSIGNED: The study shows most of the features of pemphigus is consistent in gingiva and other parts of oral mucosa. The dental practitioners should be aware of the various oral manifestations of such lesions to ensure accurate diagnosis and adequate treatment.
UNASSIGNED: The study was conducted in a private teaching dental institute and hospital setting. Out of 615 incisional biopsies received in the department of oral pathology, between June 2019 and April 2021, n = 22 samples were immune-mediated vesiculobullous lesions confirmed by clinical and histopathological diagnosis after eliminating lesions of viral origin. Patient details including age, gender, site, duration, and systemic illness were collected from the digital information archiving software and analyzed by appropriate statistics using SPSS software.
UNASSIGNED: Based on the results, 95.5% of the patients had histopathological features of intraepithelial clefting and only 4.5% of them showed subepithelial clefting. Female predilection was 6.3:1. The most common site of involvement was nonkeratinized mucosa (36.36%) and 59.09% of the patients presented with systemic illness.
UNASSIGNED: The study shows most of the features of pemphigus is consistent in gingiva and other parts of oral mucosa. The dental practitioners should be aware of the various oral manifestations of such lesions to ensure accurate diagnosis and adequate treatment.
摘要：
■囊性皮损是一组主要由免疫介导的皮肤粘膜病变，但也可能具有遗传或病毒起源。最常见的发生部位是颊粘膜，而涉及牙龈的病例数量相对较低。根据文献,尽管许多研究报道了非角化上皮中膀胱泡状病变的患病率，对其在角化口腔粘膜中的发生缺乏了解，尤其是牙龈.该研究的目的是评估免疫介导的口腔囊泡状病变的患病率，强调角化粘膜的发生，尤其是牙龈,在私人牙科医院就诊的患者中。
■这项研究是在一家私立牙科教学机构和医院环境中进行的。在口腔病理科接受的615例切开活检中，在2019年6月至2021年4月期间,n=22个样本为免疫介导的囊泡囊性病变,在消除病毒来源的病变后,经临床和组织病理学诊断证实.患者详细信息，包括年龄，性别,site,持续时间,从数字信息存档软件中收集系统性疾病,并使用SPSS软件进行适当的统计学分析.
■根据结果，95.5％的患者具有上皮内裂开的组织病理学特征，只有4.5％的患者表现为上皮下裂开。女性好发指数为6.3:1。最常见的受累部位是非角化粘膜（36.36％），59.09％的患者出现全身性疾病。
■研究表明，天疱疮的大多数特征在牙龈和口腔粘膜的其他部位是一致的。牙科医生应了解此类病变的各种口腔表现，以确保准确诊断和适当治疗。
■这项研究是在一家私立牙科教学机构和医院环境中进行的。在口腔病理科接受的615例切开活检中，在2019年6月至2021年4月期间,n=22个样本为免疫介导的囊泡囊性病变,在消除病毒来源的病变后,经临床和组织病理学诊断证实.患者详细信息，包括年龄，性别,site,持续时间,从数字信息存档软件中收集系统性疾病,并使用SPSS软件进行适当的统计学分析.
■根据结果，95.5％的患者具有上皮内裂开的组织病理学特征，只有4.5％的患者表现为上皮下裂开。女性好发指数为6.3:1。最常见的受累部位是非角化粘膜（36.36％），59.09％的患者出现全身性疾病。
■研究表明，天疱疮的大多数特征在牙龈和口腔粘膜的其他部位是一致的。牙科医生应了解此类病变的各种口腔表现，以确保准确诊断和适当治疗。
