春季角膜结膜炎(VKC)是一种慢性,双侧角膜和结膜问题,通常在年轻人中出现。VKC的特点是瘙痒,畏光,白色粘液分泌物,流泪,异物感,和角膜受累的盾牌溃疡引起的疼痛。春季角膜结膜炎属于眼部疾病。诊断是临床的,因为尚未确定该疾病的生物标志物。VKC疗法依赖于不同类型的药物,从抗组胺药和局部类固醇到环孢素或他克莫司滴眼液。在极少数情况下,还需要对溃疡清创进行手术治疗,以及晚期青光眼和白内障,过度长期使用类固醇眼药水引起的。我们对文献进行了系统的回顾,根据PRISMA指南建议。我们从2016年1月至2023年6月搜索了PubMed数据库。搜索词是Vernal,春季角膜结膜炎,VKC我们最初确定了211篇文章。筛选过程之后,根据我们的标准,有168项研究符合条件,并被纳入审查。在这项研究中,我们进行了系统的文献综述,以全面概述当前可用的诊断方法,VKC的管理,和它的治疗方法。
Vernal keratoconjunctivitis (VKC) is a chronic, bilateral corneal and conjunctival problem which typically presents in young individuals. VKC is characterized by itching, photophobia, white mucous discharge, lacrimation, foreign body sensation, and pain due to corneal involvement of shield ulcers. Vernal keratoconjunctivitis is categorized within ocular diseases. The diagnosis is clinical, as no sure biomarkers pathognomonic of the disease have yet been identified. The VKC therapy relies on different types of drugs, from antihistamines and topical steroids to cyclosporine or tacrolimus eye drops. In extremely rare cases, there is also the need for surgical treatment for the debridement of ulcers, as well as for advanced glaucoma and cataracts, caused by excessive prolonged use of steroid eye drops. We performed a systematic
review of the literature, according to PRISMA guideline recommendations. We searched the PubMed database from January 2016 to June 2023. Search terms were Vernal, Vernal keratoconjunctivitis, and VKC. We initially identified 211 articles. After the screening process, 168 studies were eligible according to our criteria and were included in the
review. In this study, we performed a systematic literature
review to provide a comprehensive overview of currently available diagnostic methods, management of VKC, and its treatments.