■利什曼病是一种媒介传播的原生动物感染,在热带和亚热带地区具有广泛的临床谱。肾脏损害通常与内脏利什曼病(VL)患者的发病率和死亡率增加有关。然而,到目前为止,关于埃塞俄比亚内脏利什曼病对肾功能分析的影响的报道非常有限。
■评估人内脏利什曼病(黑热病)患者的肾功能状况。
■从在KahsayAbera和Mear医院就诊的VL患者(n=100)和健康对照(n=100)采集人血,埃塞俄比亚西部的提格雷。根据常规方案和肾功能分析分离血清(肌酐,尿素,和尿酸)通过迈瑞200E自动化学分析仪进行分析。在这项研究中还评估了估计的肾小球滤过率(eGFR)。使用SPSS版本23.0处理获得的数据。描述性统计,独立测试,和双变量相关性用于数据分析。P值<0.05被认为在95%置信水平下具有统计学意义。
■发现平均血清肌酐水平明显升高,而与健康对照相比,VL患者各自的血清尿素和eGFR显着降低。具体来说,从100例VL病例中,血清肌酐水平升高,尿素,尿酸含量为10%,9%和15%的VL病例,分别;同时,血清尿素和eGFR从33%下降到44%的VL病例,分别。
■这项研究的发现断言内脏利什曼病会导致肾脏活动紊乱,其特征是肾功能改变。这可能表明VL是发生肾功能障碍的决定因素。这项研究鼓励研究人员参与内脏利什曼病及其对人类其他器官功能特征的影响,并确定预防和干预的潜在标志物。
UNASSIGNED: Leishmaniasis is a vector-borne protozoan infection that has a wide clinical spectrum in the tropics and subtropics. Kidney damage is frequently associated with increased morbidity and mortality in visceral leishmaniasis (VL) patients. However, up to date, there is a very limited report on the effect of visceral leishmaniasis on kidney function profiling in Ethiopia.
UNASSIGNED: To evaluate the renal function profile in human visceral leishmaniasis (kala-azar) patients.
UNASSIGNED: Human blood was taken from VL patients (n = 100) and healthy controls (n = 100) attending Kahsay Abera and Mearg Hospitals, Western Tigray of Ethiopia. Serum was separated according to the conventional protocol and kidney function profiling (creatinine,
urea, and uric acid) was analyzed by Mindray 200E automated chemistry analyzer. The estimated glomerular filtration rate (eGFR) was also assessed in this study. The obtained data were processed using SPSS Version 23.0. Descriptive statistics, independent-test, and bivariate correlations were used for data analysis. P values <0.05 were considered statistically significant at a 95% confidence level.
UNASSIGNED: The mean serum creatinine level was found significantly higher, while respective serum
urea and eGFR were significantly lower in VL patients compared to healthy controls. Specifically, from 100 VL cases, an increased level of serum creatinine,
urea, and uric acid was found in 10%, 9% and 15% VL cases, respectively; meanwhile, a decreased serum
urea and eGFR have been reported from 33% to 44% VL cases, respectively.
UNASSIGNED: The finding of this study asserted that visceral leishmaniasis causes derangement in kidney activities characterized by alteration of renal function profile. This may indicate that VL is the determinant factor for developing kidney dysfunction. This study encourages researchers to engage in visceral leishmaniasis and its effect on other organ function profiles in humans and identify potential markers for both prevention and intervention.