PDF(Pubmed)
Abstract：
BACKGROUND: Uremic stomatitis is often unfamiliar to healthcare professionals. This study presents five cases of uremic stomatitis, providing a comprehensive analysis of their demographic distribution, clinicopathological features, and management strategies based on existing literature.
METHODS: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico. Electronic searches were conducted in five databases supplemented by manual scrutiny and gray literature.
RESULTS: The series consisted of three men and two women with a mean age of 40.2 years. Lesions mostly appeared as white plaques, particularly on the tongue (100%). The median blood urea level was 129 mg/dL. Histopathological analysis revealed epithelial changes, including acanthosis and parakeratosis, with ballooned keratinocytes in the suprabasal region. Oral lesions resolved subsequent to hemodialysis in three cases (75%). Thirty-seven studies comprising 52 cases of uremic stomatitis have been described hitherto. Most patients were male (65.4%) with a mean age of 43.6 years. Clinically, grayish-white plaques (37.3%) and ulcers/ulcerations (28.9%) were common, particularly on the tongue (30.9%). Hemodialysis was performed on 27 individuals. The resolution rate of oral lesions was 53.3%.
CONCLUSIONS: Earlier recognition of uremic stomatitis, possibly associated with long-term uremia, holds the potential to improve outcomes for patients with undiagnosed chronic kidney disease.
METHODS: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico. Electronic searches were conducted in five databases supplemented by manual scrutiny and gray literature.
RESULTS: The series consisted of three men and two women with a mean age of 40.2 years. Lesions mostly appeared as white plaques, particularly on the tongue (100%). The median blood urea level was 129 mg/dL. Histopathological analysis revealed epithelial changes, including acanthosis and parakeratosis, with ballooned keratinocytes in the suprabasal region. Oral lesions resolved subsequent to hemodialysis in three cases (75%). Thirty-seven studies comprising 52 cases of uremic stomatitis have been described hitherto. Most patients were male (65.4%) with a mean age of 43.6 years. Clinically, grayish-white plaques (37.3%) and ulcers/ulcerations (28.9%) were common, particularly on the tongue (30.9%). Hemodialysis was performed on 27 individuals. The resolution rate of oral lesions was 53.3%.
CONCLUSIONS: Earlier recognition of uremic stomatitis, possibly associated with long-term uremia, holds the potential to improve outcomes for patients with undiagnosed chronic kidney disease.
摘要：
背景：尿毒症性口腔炎通常对医疗保健专业人员来说是陌生的。这项研究提出了5例尿毒症性口炎，对他们的人口分布进行全面分析，临床病理特征，和基于现有文献的管理策略。
方法：数据来自巴西各地的中心，阿根廷,委内瑞拉,和墨西哥。在五个数据库中进行了电子搜索，并辅以人工审查和灰色文献。
结果：该系列由三名男性和两名女性组成，平均年龄为40.2岁。病变大多表现为白色斑块，特别是在舌头上（100％）。血尿素水平中位数为129mg/dL。组织病理学分析显示上皮改变，包括棘皮症和角化不全,在鼻上区域有膨胀的角质形成细胞。在三例（75％）的血液透析后，口腔病变得以解决。迄今为止，已经描述了37项研究，其中包括52例尿毒症性口腔炎。大多数患者为男性（65.4％），平均年龄为43.6岁。临床上,灰白色斑块（37.3%）和溃疡/溃疡（28.9%）是常见的，特别是在舌头上（30.9%）。对27例患者进行血液透析。口腔病变的分辨率为53.3%。
结论：早期认识到尿毒症性口腔炎，可能与长期尿毒症有关,对于未确诊的慢性肾脏病患者,具有改善预后的潜力.
方法：数据来自巴西各地的中心，阿根廷,委内瑞拉,和墨西哥。在五个数据库中进行了电子搜索，并辅以人工审查和灰色文献。
结果：该系列由三名男性和两名女性组成，平均年龄为40.2岁。病变大多表现为白色斑块，特别是在舌头上（100％）。血尿素水平中位数为129mg/dL。组织病理学分析显示上皮改变，包括棘皮症和角化不全,在鼻上区域有膨胀的角质形成细胞。在三例（75％）的血液透析后，口腔病变得以解决。迄今为止，已经描述了37项研究，其中包括52例尿毒症性口腔炎。大多数患者为男性（65.4％），平均年龄为43.6岁。临床上,灰白色斑块（37.3%）和溃疡/溃疡（28.9%）是常见的，特别是在舌头上（30.9%）。对27例患者进行血液透析。口腔病变的分辨率为53.3%。
结论：早期认识到尿毒症性口腔炎，可能与长期尿毒症有关,对于未确诊的慢性肾脏病患者,具有改善预后的潜力.
