METHODS: Data were collected from centers across Brazil, Argentina, Venezuela, and Mexico. Electronic searches were conducted in five databases supplemented by manual scrutiny and gray literature.
RESULTS: The series consisted of three men and two women with a mean age of 40.2 years. Lesions mostly appeared as white plaques, particularly on the tongue (100%). The median blood urea level was 129 mg/dL. Histopathological analysis revealed epithelial changes, including acanthosis and parakeratosis, with ballooned keratinocytes in the suprabasal region. Oral lesions resolved subsequent to hemodialysis in three cases (75%). Thirty-seven studies comprising 52 cases of uremic stomatitis have been described hitherto. Most patients were male (65.4%) with a mean age of 43.6 years. Clinically, grayish-white plaques (37.3%) and ulcers/ulcerations (28.9%) were common, particularly on the tongue (30.9%). Hemodialysis was performed on 27 individuals. The resolution rate of oral lesions was 53.3%.
CONCLUSIONS: Earlier recognition of uremic stomatitis, possibly associated with long-term uremia, holds the potential to improve outcomes for patients with undiagnosed chronic kidney disease.
方法:数据来自巴西各地的中心,阿根廷,委内瑞拉,和墨西哥。在五个数据库中进行了电子搜索,并辅以人工审查和灰色文献。
结果:该系列由三名男性和两名女性组成,平均年龄为40.2岁。病变大多表现为白色斑块,特别是在舌头上(100%)。血尿素水平中位数为129mg/dL。组织病理学分析显示上皮改变,包括棘皮症和角化不全,在鼻上区域有膨胀的角质形成细胞。在三例(75%)的血液透析后,口腔病变得以解决。迄今为止,已经描述了37项研究,其中包括52例尿毒症性口腔炎。大多数患者为男性(65.4%),平均年龄为43.6岁。临床上,灰白色斑块(37.3%)和溃疡/溃疡(28.9%)是常见的,特别是在舌头上(30.9%)。对27例患者进行血液透析。口腔病变的分辨率为53.3%。
结论:早期认识到尿毒症性口腔炎,可能与长期尿毒症有关,对于未确诊的慢性肾脏病患者,具有改善预后的潜力.