癌症,全球第二大死亡原因,经常导致晚期癌症患者如前列腺癌,乳房,还有肺癌.这些转移的存在有助于骨骼相关事件(SRE)的发生,定义为过度疼痛,病理性骨折,高钙血症,和脊髓压迫。这些有害事件在每个癌症患者的生活质量中都留下了令人不安的大洞。原发性骨癌,包括骨肉瘤(OS),软骨肉瘤(CS),和尤因肉瘤(ES),起源不清楚。MicroRNA(miRNA)表达模式在原发性骨癌如OS、CS,ES,表明在肿瘤发展中的作用,入侵,转移,和治疗反应。这些miRNA在循环中持续存在,并在许多形式的骨肿瘤中表现出不同的模式,使它们成为早期发现和治疗此类疾病的潜在生物标志物。鉴于它们在各种生物过程和条件下的关键调节功能,包括癌症,这项研究旨在观察miRNAs的活性和对骨恶性肿瘤的可能贡献,专注于操作系统,CS,和ES。总之,miRNA是有价值的诊断工具,监测,并预测操作系统,CS,和ES结果。需要进一步的研究来充分理解miRNA在这些骨癌中的复杂参与并开发有效的基于miRNA的治疗。
Cancer, the second greatest cause of mortality worldwide, frequently causes bone me-tastases in patients with advanced-stage carcinomas such as prostate, breast, and lung cancer. The existence of these metastases contributes to the occurrence of skeletal-related events (SREs), which are defined by excessive pain, pathological fractures, hypercalcemia, and spinal cord com-pression. These injurious incidents leave uncomfortably large holes in each of the cancer patient\'s life quality. Primary bone cancers, including osteosarcoma (OS), chondrosarcoma (CS), and Ewing\'s sarcoma (ES), have unclear origins. MicroRNA (miRNA) expression patterns have been changed in primary bone cancers such as OS, CS, and ES, indicating a role in tumor development, invasion, metastasis, and treatment response. These miRNAs are persistent in circulation and ex-hibit distinct patterns in many forms of bone tumors, making them potential biomarkers for early detection and treatment of such diseases. Given their crucial regulatory functions in various bio-logical processes and conditions, including cancer, this study aims to look at miRNAs\' activities and possible contributions to bone malignancies, focusing on OS, CS, and ES. In conclusion, miRNAs are valuable tools for diagnosing, monitoring, and predicting OS, CS, and ES outcomes. Further research is required to fully comprehend the intricate involvement of miRNAs in these bone cancers and to develop effective miRNA-based treatments.