PDF(Pubmed)
Abstract：
Tumor angiogenesis, the formation of new blood vessels to support tumor growth and metastasis, is a complex process regulated by a multitude of signaling pathways. Dysregulation of signaling pathways involving protein kinases has been extensively studied, but the role of protein phosphatases in angiogenesis within the tumor microenvironment remains less explored. However, among angiogenic pathways, protein phosphatases play critical roles in modulating signaling cascades. This review provides a comprehensive overview of the involvement of protein phosphatases in tumor angiogenesis, highlighting their diverse functions and mechanisms of action. Protein phosphatases are key regulators of cellular signaling pathways by catalyzing the dephosphorylation of proteins, thereby modulating their activity and function. This review aims to assess the activity of the protein tyrosine phosphatases and serine/threonine phosphatases. These phosphatases exert their effects on angiogenic signaling pathways through various mechanisms, including direct dephosphorylation of angiogenic receptors and downstream signaling molecules. Moreover, protein phosphatases also crosstalk with other signaling pathways involved in angiogenesis, further emphasizing their significance in regulating tumor vascularization, including endothelial cell survival, sprouting, and vessel maturation. In conclusion, this review underscores the pivotal role of protein phosphatases in tumor angiogenesis and accentuate their potential as therapeutic targets for anti-angiogenic therapy in cancer.
摘要：
肿瘤血管生成,支持肿瘤生长和转移的新血管的形成，是由多种信号通路调节的复杂过程。涉及蛋白激酶的信号通路的失调已经被广泛研究,但是蛋白磷酸酶在肿瘤微环境中血管生成中的作用仍未被研究。然而,在血管生成途径中，蛋白磷酸酶在调节信号级联中起关键作用。本文综述了蛋白磷酸酶在肿瘤血管生成中的作用,突出它们的不同功能和行动机制。蛋白质磷酸酶通过催化蛋白质的去磷酸化作用，是细胞信号通路的关键调节因子。从而调节它们的活动和功能。这篇综述旨在评估蛋白质酪氨酸磷酸酶和丝氨酸/苏氨酸磷酸酶的活性。这些磷酸酶通过各种机制对血管生成信号通路发挥作用，包括血管生成受体和下游信号分子的直接去磷酸化。此外，蛋白磷酸酶也与参与血管生成的其他信号通路发生串扰，进一步强调它们在调节肿瘤血管化方面的重要性，包括内皮细胞存活,发芽，和血管成熟。总之,这篇综述强调了蛋白磷酸酶在肿瘤血管生成中的关键作用,并强调了它们作为肿瘤抗血管生成治疗靶点的潜力.
