%0 Journal Article
%T PD-L1 expression and its correlation with tumor biomarkers in Chinese urothelial bladder cancer.
%A Fan Y
%A Dai T
%A Zhang D
%A Guo H
%A Zhou F
%A Shi B
%A Wang S
%A Ji Z
%A Wang C
%A Yao X
%A Wei Q
%A Chen N
%A Xing J
%A Yang J
%A Kong C
%A Huang J
%A Ye D
%A Zhou L
%J Sci Rep
%V 14
%N 1
%D 2024 07 20
%M 39033240
%F 4.996
%R 10.1038/s41598-024-67508-6
%X Data on prevalence of programmed death ligand-1 (PD-L1) expression and its correlation with tumor biomarkers in Chinese patients with muscle-invasive urothelial bladder cancer (MIUBC) are scarce. We investigated the prevalence of PD-L1 expression, PD-L1 expression in tumor cells (TC) and immune cells (IC), and its correlation with tumor biomarkers (CD8+ T cells and tumor mutation burden [TMB]) in Chinese patients with newly diagnosed MIUBC (NCT03433924). Of 248 patients enrolled, 229 with PD-L1 data available were analysed. High PD-L1 expression (≥ 25% of TC or IC with PD-L1 expression) was observed in 120 (52.4%) patients. 59 cases showed positive staining in ≥ 25% of TC, and 82 cases had positive staining in ≥ 25% of IC. High expression of CD8+ T cell and TMB (> 10 mutations/megabase) was observed in 44.5% and 54.1% patients, respectively. A positive correlation was observed between percentage of TC with membrane PD-L1 positivity and CD8+ T cells (0.34; P < 0.001) and between IC with membrane PD-L1 positivity and CD8+ T cells (0.44; P < 0.001). There is high prevalence of PD-L1 expression in Chinese patients with MIUBC, suggesting that a sizable subset of patients could benefit from immunotherapy. The correlation of PD-L1 expression with tumor biomarkers provide clues for mechanisms underlying the effects of biomarkers for predicting efficacy.