■心室回声灶是一些胎儿心脏内的小结构。这些小区域是由于位于乳头状肌附近的胎儿的心室中回声增加所致。已经报道了这些病灶与胎儿染色体异常之间的关联。考虑到染色体异常是产前死亡的主要原因,本研究旨在确定胎儿回声灶作为染色体异常标志物的价值。
■由经验丰富的心脏病专家对149名孕中期孕妇进行胎儿超声心动图检查。其中,据报道有75例具有阳性回声灶,据报道有74例没有回声灶。随后,检查了三个染色体异常,包括三体21、18和13。个人的信息,包括胎龄和回声灶,被记录下来。
■根据本研究的结果,7名婴儿(4.7%)患有21三体,4名婴儿(2.7%)患有13三体,6名婴儿(4.1%)患有18三体.回声灶阳性和阴性的孕妇的平均胎龄分别为21.07±3.23和21.03±3.09。在心室回声灶与21、18或13三体之间没有发现显着关系。
■本研究表明,回声灶的存在与染色体三体之间没有显着关系。这一发现表明,当心内存在回声灶时,需要额外的检查来确认染色体异常。尤其是高危胎儿.此外,无回声病灶并不能排除染色体疾病.
UNASSIGNED: Ventricular echogenic foci are small structures within the hearts of some fetuses. These small areas result from increased echogenicity in the ventricles of fetuses located near the papillary muscles. An association between these foci and chromosomal abnormalities in fetuses has been reported. Considering that chromosomal abnormalities are a major cause of prenatal death, this study aimed to determine the value of fetal echogenic foci as markers for chromosomal abnormalities.
UNASSIGNED: Fetal echocardiography was performed by an experienced cardiologist on 149 pregnant women in the second trimester. Of these, 75 were reported to have positive echogenic foci, and 74 were reported to have no echogenic foci. Subsequently, the three chromosomal anomalies including trisomies 21, 18, and 13 were examined. The information of the individuals, including gestational age and echogenic foci, was recorded.
UNASSIGNED: Based on the findings of the present study, seven infants (4.7%) had trisomy 21, four infants (2.7%) had trisomy 13, and six infants (4.1%) had trisomy 18. The mean gestational age of pregnant women with positive and negative echogenic foci was 21.07±3.23 and 21.03±3.09, respectively. No significant relationship was found between ventricular echogenic foci and trisomy 21, 18, or 13.
UNASSIGNED: The present study suggests no significant relation between the presence of echogenic foci and chromosomal trisomies. This finding indicates that additional tests are required to confirm chromosomal abnormalities when echogenic intracardiac foci are present, especially in high-risk fetuses. Moreover, the absence of echogenic focus does not rule out chromosomal disorders.