PDF(Pubmed)
Abstract：
Background: Down syndrome (DS) is a genetic condition characterized by an extra copy of chromosome 21, resulting in various physical and cognitive features. This study aimed to comprehensively analyze the dental and craniofacial morphology of individuals with DS using Cone Beam Computed Tomography (CBCT). Methods: Six individuals with DS, comprising five males and one female aged 17 to 35 years, underwent CBCT scanning. Radiographic assessments included dentition, occlusion, paranasal sinuses, airway, skull bones, and suture calcification. Linear and angular cephalometric measurements were performed, and airway analysis was conducted using Dolphin 3D imaging software v.11. Results: The study revealed prognathic maxilla in five patients, prognathic mandible in four, and bimaxillary protrusion in two. Dental findings included microdontia, enamel hypoplasia, and congenitally missing teeth, with maxillary and mandibular third molars most commonly absent. Sinus abnormalities, delayed suture closure, and cervical spine anomalies were also observed. Conclusion: These findings contribute to a deeper understanding of DS-related craniofacial characteristics and emphasize the importance of considering these morphometric features in clinical management strategies for individuals with DS. This study\'s limited sample size underscores the significance of radiographic assessment in planning interventions such as cosmetic reconstructions, prosthetic rehabilitation, or orthodontic treatment for individuals with DS.
摘要：
背景：唐氏综合症（DS）是一种遗传病，其特征是21号染色体的额外拷贝，导致各种身体和认知特征。本研究旨在使用锥形束计算机断层扫描（CBCT）全面分析DS患者的牙齿和颅面形态。方法：6名DS患者，包括五名男性和一名女性，年龄在17至35岁之间，行CBCT扫描。射线照相评估包括牙列，遮挡,鼻旁窦,气道,头骨,和缝线钙化。进行线性和角度头颅测量，并使用Dolphin3D成像软件v.11进行气道分析。结果：研究显示5例上颌骨前突，前颌下颌骨四，和双腋窝突出。牙科检查结果包括microdontia,釉质发育不全,先天性牙齿缺失，上颌和下颌第三磨牙最常缺失。窦异常,延迟缝合,并观察到颈椎异常。结论：这些发现有助于更深入地了解与DS相关的颅面特征，并强调在DS患者的临床管理策略中考虑这些形态特征的重要性。这项研究的有限的样本量强调了射线照相评估在计划干预措施如美容重建中的重要性，假肢康复,或DS患者的正畸治疗。
