环境中存在的大量污染物可以持续很长时间，它们潜在的毒性作用可以从父母转移到后代。因此，有必要研究环境污染物跨多代的毒性以及生物体的潜在机制。由于其生命周期短和对环境暴露的敏感性，秀丽隐杆线虫是多代环境污染物毒性评价的重要动物模型。在这次审查中,我们介绍了各种环境污染物对秀丽隐杆线虫的跨代和多代毒性。此外，我们讨论了在秀丽隐杆线虫中观察到的环境污染物的跨代和多代毒性的潜在机制。
A large number of pollutants existing in the environment can last for a long time, and their potential toxic effects can transfer from parents to their offspring. Thus, it is necessary to investigate the toxicity of environmental pollutants across multigenerations and the underlying mechanisms in organisms. Due to its short life cycle and sensitivity to environmental exposures, Caenorhabditis elegans is an important animal model for toxicity assessment of environmental pollutants across multigenerations. In this
review, we introduced the transgenerational and multigenerational toxicity caused by various environmental pollutants in C. elegans. Moreover, we discussed the underlying mechanisms for the observed transgenerational and multigenerational toxicity of environmental contaminants in C. elegans.
