■有先兆子痫(PE)病史的女性患晚年心血管疾病(CVD)的风险高达五倍。虽然已知PE和CVD具有共同的临床和分子特征,有有限的研究调查他们共同的基因组学(遗传学,表观遗传学或转录组学)随时间的变化。因此,我们试图系统地回顾文献,以确定关注PE后发生CVD的基因组进展的纵向研究.
■通过PubMed对主要来源进行文献检索,Scopus,通过OVID进行WebofScience和Embase。1980年1月1日至2023年7月28日发表的关于PE和CVD基因组学研究的研究符合纳入条件。纳入的研究是根据Cochrane系统评价指南和PRISMA2020清单进行筛选的。使用纽卡斯尔-渥太华量表进一步评估合格文章的质量。
■共筛选了9,231篇文章,14项研究接受了质量评估。经过进一步评估,6项研究被纳入最终审查.所有六项研究在CVD/危险因素作为结果方面都是异质的,基因定位方法,和不同的目标基因。相关基因为RGS2、LPA、和AQP3,与miR-122-5p一起,miR-126-3p,miR-146a-5p,还有miR-206.此外,鉴定了12个可能与PE后晚年CVD相关的差异甲基化区域。所有六项研究中唯一的共同变量是使用病例对照研究设计。
■我们的结果为研究PE后CVD的基因组研究的异质性提供了重要的见解,并强调迫切需要进行纵向研究以进一步研究PE后CVD进展的遗传变异。
UNASSIGNED: Women with a history of preeclampsia (PE) have been shown to have up to five times the risk of developing later-life cardiovascular disease (CVD). While PE and CVD are known to share clinical and molecular characteristics, there are limited studies investigating their shared genomics (genetics, epigenetics or transcriptomics) variation over time. Therefore, we sought to systematically
review the literature to identify longitudinal studies focused on the genomic progression to CVD following PE.
UNASSIGNED: A literature search of primary sources through PubMed, Scopus, Web of Science and Embase via OVID was performed. Studies published from January 1, 1980, to July 28, 2023, that investigated genomics in PE and CVD were eligible for inclusion. Included studies were screened based on Cochrane systematic
review guidelines in conjunction with the PRISMA 2020 checklist. Eligible articles were further assessed for quality using the Newcastle-Ottawa scale.
UNASSIGNED: A total of 9,231 articles were screened, with 14 studies subjected to quality assessment. Following further evaluation, six studies were included for the final
review. All six of these studies were heterogeneous in regard to CVD/risk factor as outcome, gene mapping approach, and in different targeted genes. The associated genes were RGS2, LPA, and AQP3, alongside microRNAs miR-122-5p, miR-126-3p, miR-146a-5p, and miR-206. Additionally, 12 differentially methylated regions potentially linked to later-life CVD following PE were identified. The only common variable across all six studies was the use of a case-control study design.
UNASSIGNED: Our results provide critical insight into the heterogeneous nature of genomic studies investigating CVD following PE and highlight the urgent need for longitudinal studies to further investigate the genetic variation underlying the progression to CVD following PE.