■关于疾病的形态学谱，低估了左心室致密化非（LVNC）中致密心肌和过度小梁的功能评估。我们的目的是评估是否同时测量左心室（LV）容积，通过与心肌小梁形成过多的正常人相比，在电影磁共振（cineMR）中有或没有小梁形成的质量和射血分数（LVEF）可以帮助诊断LVNC患者。
■这项回顾性单中心磁共振成像研究（Bichat大学医院）对2011年3月至2018年10月在超声心动图上观察到的67例连续超声心动图超梁患者进行了研究，其中包括30例已知LVNC的患者和16例单纯超梁的对照受试者（非紧凑/紧凑（NC/C）比率在1.8至2.2之间，使用标准SSFP前序列的小梁包括10LV体积,使用CVI42软件测量有无小梁夹杂物的质量和LVEF。对20例患者和14例对照进行了随访研究。使用学生配对t检验比较功能参数。计算了皮尔逊积矩相关系数。Bland-Altman分析确定了阅读器之间和内部功能数据的再现性。
■当从测量中排除小梁（即非致密心肌）时，患者和对照组的LVEF均在正常范围内，而当小梁包含在心内膜轮廓中时，LVNC中增加了9.8％±1.6％，而对照组中减少了10.9％±1.4％（P<0.0001）。根据LVNC的舒张或收缩期，总体心肌质量保持稳定，而对照组则显着降低。
■根据是否包括小梁，LVNC患者和对照组之间的LVEF测量结果显着不同。这些独特的测量可用作辅助临床工具，以帮助确认LVNC的诊断。
UNASSIGNED: Functional assessment of compact myocardium and hypertrabeculations in left ventricular non-compaction (LVNC) is underestimated with regards to the morphological spectrum of disease. We aimed to assess whether measuring concurrently left ventricular (LV) volume, mass and ejection fraction (LVEF) with and without
trabeculation inclusion on cine magnetic resonance (cineMR) could help diagnose patients with LVNC by comparison to normal individuals with an excess of myocardial trabeculations.
UNASSIGNED: This retrospective single center magnetic resonance imaging
study (Bichat University Hospital) of 67 consecutive patients with echocardiographic hypertrabeculations seen at echocardiography between March 2011 and October 2018 included 30 patients with known LVNC and 16 control subjects with simple hypertrabeculations (non-compact/compact (NC/C) ratio between 1.8 and 2.2, trabeculations involving 10% to 17% of the left ventricle) using steady-state free precession (SSFP) cine sequences in the standard views. LV volumes, mass and LVEF were measured with and without
trabeculation inclusion using CVI42 software. Follow-up was studied in 20 patients and 14 controls. Functional parameters were compared using Student\'s paired t-test. Pearson product moment correlation coefficients were calculated. Bland-Altman analysis determined the inter- and intra-reader functional data reproducibility.
UNASSIGNED: When excluding the trabeculations (i.e. non-compacted myocardium) from measurements, LVEF was within normal ranges both in patients and controls, while it increased by 9.8%±1.6% in LVNC and decreased by 10.9%±1.4% in controls when trabeculae were included in the endocardial contours (P<0.0001). The overall myocardial mass remained stable according to the diastolic or systolic phase in LVNC whereas it significantly decreased in controls.
UNASSIGNED: Depending whether trabeculations were included or not, LVEF measurements were significantly different between patients with LVNC and controls. These distinctive measurements might be used as an adjunctive clinical tool to help confirm the diagnosis of LVNC.
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