维生素E具有抗氧化特性,与预防疟疾有关。当前的研究使用系统评价和荟萃分析方法,研究了疟疾患者与未感染个体相比血液中维生素E水平的差异。系统评价方案在PROSPERO(CRD4202341481)注册。在Embase上进行了相关研究的搜索,MEDLINE,奥维德,PubMed,Scopus,ProQuest,谷歌学者。使用随机效应模型估算了疟疾患者与未感染个体相比维生素E水平差异的综合效应估计值(Cohen'sd)。搜索产生了2009年的记录,系统评价中纳入了23项研究.大多数研究(80%)发现,疟疾患者的维生素E水平明显低于未感染的患者。总的来说,结果显示,与未感染者相比,疟疾患者的血液维生素E水平显着降低(p<0.01,Cohen\sd:-2.74,95%CI:-3.72-(-1.76),I2:98.69%,21项研究)。严重疟疾患者的血液维生素E水平显着降低,与那些经历较不严重疾病形式的人相比(p<0.01,科恩d:-0.56,95%CI:-0.85-(-0.26),I2:0%,2项研究),但恶性疟原虫或间日疟原虫患者的血液维生素E水平没有变化(p=0.13,科恩d:-1.15,95%CI:-2.62-0.33,I2:93.22%,3项研究)。总之,本研究强烈表明,疟疾患者的维生素E水平显着降低,在严重疟疾病例中观察到更明显的下降。然而,疟疾寄生虫的类型,特别是恶性疟原虫或间日疟原虫,该研究强调了维生素E在疟疾发病机制中的潜在作用,并表明改善维生素E状态可能有利于改善疾病结局。
Vitamin E has an antioxidant property and is associated with protection against malaria. The current study used systematic
review and meta-analysis approaches examining the variance in blood levels of vitamin E in malaria patients as compared with uninfected individuals. The protocol for the systematic
review was registered with PROSPERO (CRD4202341481). Searches for pertinent studies were carried out on Embase, MEDLINE, Ovid, PubMed, Scopus, ProQuest, and Google Scholar. The combined effect estimate (Cohen\'s d) of the difference in vitamin E levels in malaria patients as compared with uninfected individuals was estimated using the random effects model. The searches yielded 2009 records, and 23 studies were included in the systematic
review. The majority of the studies (80%) found that vitamin E levels were significantly lower in malaria patients than those who were not infected. Overall, the results revealed a significant reduction in blood levels of vitamin E in malaria patients when compared with uninfected individuals (p < 0.01, Cohen\'s d: -2.74, 95% CI: -3.72-(-1.76), I2: 98.69%, 21 studies). There was a significant reduction in blood levels of vitamin E in patients suffering from severe malaria, in comparison with those experiencing less severe forms of the disease (p < 0.01, Cohen\'s d: -0.56, 95% CI: -0.85-(-0.26), I2: 0%, 2 studies), but no variation in blood levels of vitamin E among patients suffering from either P. falciparum or P. vivax malaria (p = 0.13, Cohen\'s d: -1.15, 95% CI: -2.62-0.33, I2: 93.22%, 3 studies). In summary, the present study strongly suggests that vitamin E levels are significantly reduced in malaria patients, with a more pronounced decrease observed in cases of severe malaria. However, the type of malaria parasite, specifically P. falciparum or P. vivax, did not appear to influence the levels of vitamin E. This study highlights the potential role of vitamin E in the pathogenesis of malaria and suggests that improved vitamin E status might be beneficial for improving disease outcomes.