PDF(Pubmed)
Abstract：
Pancreatic cancer is the leading cause of cancer mortality worldwide. Research investigating effective management strategies for pancreatic cancer is ongoing. Vitamin E, consisting of both tocopherol and tocotrienol, has demonstrated debatable effects on pancreatic cancer cells. Therefore, this scoping review aims to summarize the effects of vitamin E on pancreatic cancer. In October 2022, a literature search was conducted using PubMed and Scopus since their inception. Original studies on the effects of vitamin E on pancreatic cancer, including cell cultures, animal models and human clinical trials, were considered for this review. The literature search found 75 articles on this topic, but only 24 articles met the inclusion criteria. The available evidence showed that vitamin E modulated proliferation, cell death, angiogenesis, metastasis and inflammation in pancreatic cancer cells. However, the safety and bioavailability concerns remain to be answered with more extensive preclinical and clinical studies. More in-depth analysis is necessary to investigate further the role of vitamin E in the management of pancreatic cancers.
摘要：
胰腺癌是全球癌症死亡的主要原因。研究胰腺癌的有效管理策略正在进行中。维生素E,由生育酚和生育三烯酚组成，已经证明对胰腺癌细胞有争议的作用。因此,本综述旨在总结维生素E对胰腺癌的影响。2022年10月，自成立以来，使用PubMed和Scopus进行了文献检索。关于维生素E对胰腺癌影响的原始研究，包括细胞培养,动物模型和人体临床试验，被考虑参加这次审查。文献检索找到了75篇关于这个主题的文章，但只有24篇文章符合纳入标准。现有证据表明，维生素E调节增殖，细胞死亡,血管生成,胰腺癌细胞的转移和炎症。然而,安全性和生物利用度问题仍有待更广泛的临床前和临床研究来解决.需要进行更深入的分析，以进一步研究维生素E在胰腺癌治疗中的作用。
