目的:本研究旨在评估维生素A和E的形式(单独和共同)与前列腺癌风险之间的关联。以及识别潜在的效果修改器。
方法:利用新加坡前列腺癌研究的数据,一项以医院为基础的病例对照研究,我们测量了156名前列腺癌患者和118名对照受试者的15种不同形式的维生素A和E的血清浓度,使用高效液相色谱技术。这些形式包括视黄醇,叶黄素,玉米黄质,α-隐黄质,β-隐黄质,α-胡萝卜素,β-胡萝卜素,番茄红素,泛醌,δ-生育酚,γ-生育酚,α-生育酚,δ-生育三烯酚,γ-生育三烯酚,和α-生育三烯酚。维生素A和E与前列腺癌风险之间关联的比值比和95%置信区间在校正潜在的混杂因素后使用逻辑回归模型进行估计。根据吸烟和饮酒状况对分析进行了进一步分层。使用加权分位数和回归评估微量营养素组的混合效应。
结果:更高浓度的视黄醇,叶黄素,α-胡萝卜素,β-胡萝卜素,泛醌,α-生育酚,δ-生育三烯酚,γ-生育三烯酚,和α-生育三烯酚与总体前列腺癌风险显著正相关。在吸烟者中,叶黄素的关联更强,β-隐黄质和β-胡萝卜素与从不吸烟者的比较。在经常喝酒的人中,叶黄素的关联更强,β-隐黄质,泛醌,γ-生育三烯酚和α-生育三烯酚与非正规饮酒者比较。视黄醇和α-生育三烯酚对“维生素A和维生素A类胡萝卜素”和“维生素E”组指数的贡献最大,分别。
结论:几种血清维生素A和E形式与前列腺癌风险相关,吸烟和饮酒状况的显著影响。我们的发现揭示了前列腺癌的病因。
OBJECTIVE: This
study aimed to assess associations between forms of vitamin A and E (both individually and collectively) and the risk of prostate cancer, as well as identify potential effect modifiers.
METHODS: Utilizing data from the Singapore Prostate Cancer
Study, a hospital-based case-control
study, we measured the serum concentrations of 15 different forms of vitamins A and E in 156 prostate cancer patients and 118 control subjects, using a high-performance liquid chromatography technique. These forms included retinol, lutein, zeaxanthin, α-cryptoxanthin, β-cryptoxanthin, α-carotene, β-carotene, lycopene, ubiquinone, δ-
tocopherol, γ-
tocopherol, α-
tocopherol, δ-tocotrienol, γ-tocotrienol, and α-tocotrienol. The odds ratio and 95% confidence interval for associations between vitamin A and E and prostate cancer risk were estimated using logistic regression models after adjustment for potential confounders. The analyses were further stratified by smoking and alcohol consumption status. The mixture effect of micronutrient groups was evaluated using weighted quantile sum regression.
RESULTS: Higher concentrations of retinol, lutein, α-carotene, β-carotene, ubiquinone, α-tocopherol, δ-tocotrienol, γ-tocotrienol, and α-tocotrienol were significantly and positively associated with overall prostate cancer risk. Among ever-smokers, associations were stronger for lutein, β-cryptoxanthin and β-carotene compared with never-smokers. Among regular alcohol drinkers, associations were stronger for lutein, β-cryptoxanthin, ubiquinone, γ-tocotrienol and α-tocotrienol compared with non-regular alcohol drinkers. Retinol and α-tocotrienol contributed most to the group indices \'vitamin A and provitamin A carotenoids\' and \'vitamin E\', respectively.
CONCLUSIONS: Several serum vitamin A and E forms were associated with prostate cancer risk, with significant effect modification by smoking and alcohol consumption status. Our findings shed light on prostate cancer etiology.