目的:确定单绒毛膜羊膜双胎(MCDA)双胎妊娠选择性胎儿生长受限(sFGR)处理的现行做法。
方法:横断面调查。
方法:国际。
方法:临床医生参与管理MCDA双胎妊娠伴sFGR。
方法:结构化,自我管理调查。
方法:临床实践和对诊断标准和管理策略的态度。
结果:总体而言,62.8%(113/180)的临床医生完成了调查;其中,66.4%(75/113)的受访者报告说,他们将对较小的双胞胎使用<10百分位数的估计胎儿体重(EFW)和>25%的双胞胎间EFW不一致性来诊断sFGR。对于早发性I型sFGR,79.8%(75/94)的受访者表示预期管理将是他们的常规做法。另一方面,对于早发性II型和III型sFGR,19.3%(17/88)和35.7%(30/84)的受访者会预期管理这些怀孕,而71.6%(63/88)和57.1%(48/84)会将这些怀孕转诊到胎儿干预中心或为II型和III型病例提供胎儿干预,分别。此外,39.0%(16/41)的受访者会考虑胎儿镜激光手术(FLS)治疗早发性I型sFGR,而41.5%(17/41)会提供FLS或选择性杀虫剂,12.2%(5/41)将专门提供选择性杀鸡药。对于早发性II型和III型sFGR病例,25.9%(21/81)和31.4%(22/70)将独家提供FLS,分别,而33.3%(27/81)和32.9%(23/70)的人会专门提供选择性杀鸡药。
结论:在MCDA双胎妊娠中,临床医生对早发sFGR的管理实践和态度存在显著差异,特别是对于II型和III型病例,强调需要高水平的证据来指导管理。
OBJECTIVE: To identify current practices in the management of selective fetal growth restriction (sFGR) in monochorionic diamniotic (MCDA) twin pregnancies.
METHODS: Cross-sectional
survey.
METHODS: International.
METHODS: Clinicians involved in the management of MCDA twin pregnancies with sFGR.
METHODS: A structured, self-administered
survey.
METHODS: Clinical practices and attitudes to diagnostic criteria and management strategies.
RESULTS: Overall, 62.8% (113/180) of clinicians completed the
survey; of which, 66.4% (75/113) of the respondents reported that they would use an estimated fetal weight (EFW) of <10th centile for the smaller twin and an inter-twin EFW discordance of >25% for the diagnosis of sFGR. For early-onset type I sFGR, 79.8% (75/94) of respondents expressed that expectant management would be their routine practice. On the other hand, for early-onset type II and type III sFGR, 19.3% (17/88) and 35.7% (30/84) of respondents would manage these pregnancies expectantly, whereas 71.6% (63/88) and 57.1% (48/84) would refer these pregnancies to a fetal intervention centre or would offer fetal intervention for type II and type III cases, respectively. Moreover, 39.0% (16/41) of the respondents would consider fetoscopic laser surgery (FLS) for early-onset type I sFGR, whereas 41.5% (17/41) would offer either FLS or selective feticide, and 12.2% (5/41) would exclusively offer selective feticide. For early-onset type II and type III sFGR cases, 25.9% (21/81) and 31.4% (22/70) would exclusively offer FLS, respectively, whereas 33.3% (27/81) and 32.9% (23/70) would exclusively offer selective feticide.
CONCLUSIONS: There is significant variation in clinician practices and attitudes towards the management of early-onset sFGR in MCDA twin pregnancies, especially for type II and type III cases, highlighting the need for high-level evidence to guide management.