silicones

有机硅
  • 文章类型: Case Reports
    为了为有需要的儿童获得助听器,在准备耳模时看到并发症是不寻常的。然而,我们遇到了2例,由于长期服用硅模印模进行助听器验配,异物残留在中耳。一名患者在2年后出现,另一名患者在10年助听器安装后出现。我们报告了2例在探查鼓室切开术中意外发现的硅印模材料长期留在中耳的情况。这些报告的病例是世界上报告的少数病例之一,没有明确的已知发病率。这需要耳鼻喉科医师和负责印象的听力学家进行适当的检查以防止此类并发症。
    It is unusual to see complications with the preparation of ear mold in order to get hearing aids for children who are in need. However, we came across 2 cases who had a foreign body retained in the middle ear after a long period of time from taking silicon mold impression for hearing aid fitting. One patient presented after 2 years, and the other patient presented after 10 years of hearing aid fitting. We are reporting 2 cases with silicon impression material left in the middle ear for a long period of time after taking an impression for hearing aid fitting and found unexpectedly during exploratory tympanotomy. These reported cases are among the few cases reported worldwide without clear known incidence. This necessitates proper examination by otolaryngologists and the audiologists who are responsible for taking the impression to prevent such complications.
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  • 文章类型: Case Reports
    纳入研究的2例患者患有混合型和难治性结核后气管支气管狭窄(PTTS),术前经历过球囊扩张和V形支架置入等不成功的介入治疗。安全放置L形硅胶支架后,术后第1个月和第3个月的纤维支气管镜检查显示,两名患者的支气管粘膜炎症均显着减少。此外,上部和下部分支段的开口直径增加,胸部CT扫描显示左肺病变明显吸收。手术后三个月,纤维支气管镜检查证实支架固定稳定,无任何运动。患者的肺功能有了实质性的改善,呼吸困难指数,和血气分析,没有报告的不良并发症。7个月后,1例纤维支气管镜随访显示支架固定效果良好。同时,胸部CT扫描显示有利的再扩张。L形硅胶支架的放置证明可有效防止移位,缓解气道狭窄或阻塞,并确保PTTS治疗的安全性和有效性-特别是在V形硅胶支架置入失败的情况下。据我们所知,这是第一项描述2例PTTS患者使用L型硅胶支架的研究.
    使用特殊的L形硅胶支架成功治疗因肺结核引起的严重气道狭窄本文讲述了两名患有肺结核后气管支气管狭窄(PTS)的复杂肺部疾病的患者的故事。想象一下你的气道-将空气输送到肺部的管道-由于过去的肺结核发作而严重伤痕累累并变窄。这两名患者尝试了以前的治疗方法,如球囊扩张(在狭窄的气道内膨胀一个小球囊以使其变宽)和使用V形支架(放置在气道中以保持其打开的柔性支撑),但是这些方法并不能提供持久的缓解。在这种创新的方法中,医生使用了专门设计用于患者气道受影响部位的L形硅胶支架。放置这些支架后,定期检查显示出显着的改善。气道内膜肿胀明显减轻,通向肺部上部和下部的开口变得更宽。胸部X光片(CT扫描)甚至显示患者的左肺愈合良好。三个月后,支架牢牢地保持在原位,两个病人都没有遇到任何问题。呼吸变得更容易,肺功能检查有所改善,血液测试显示氧气水平更好。七个月后,一名患者继续做得非常好,支架牢固固定,胸部扫描显示肺部扩张良好。这项开创性的研究表明,当其他方法失败时,使用L形硅胶支架可以有效治疗PTTS。他们不仅呆在原地,防止堵塞,但它们也安全有效地缓解了气道狭窄。这是第一次在PTTS患者中成功使用这种L形支架,为面临类似挑战的人们带来新的希望。
    The two patients included in the study had mixed and refractory post-tuberculosis tracheobronchial stenosis (PTTS), having experienced unsuccessful interventional therapies such as balloon dilation and V-shaped stent placement before the operation. Following the secure placement of L-shaped silicone stents, examinations with a fiberbronchoscope during the first and third months post-operation revealed a significant reduction in bronchial mucosa inflammation for both patients. Additionally, the opening diameter of the upper and lower branch segments increased, and chest CT scans indicated a noticeable absorption of left pulmonary lesions. Three months post-operation, fiberbronchoscopy confirmed the stable fixation of the stent without any movement. The patients exhibited substantial improvements in pulmonary function, dyspnea index, and blood gas analysis, with no reported adverse complications. After 7 months, a follow-up fiberbronchoscope for one case revealed excellent stent fixation. Simultaneously, the chest CT scan indicated favorable re-expansion. The placement of L-shaped silicone stents proves effective in preventing displacement, alleviating airway stenosis or obstruction, and ensuring the safety and efficacy of PTTS treatment - particularly in cases where V-shaped silicone stent placement has failed. To our knowledge, this is the first study describing the L-shaped silicone stent in two patients with PTTS.
    Successful treatment of severe airway narrowing due to tuberculosis using special L-shaped silicone stentsThis article tells the story of two patients who suffered from a complex lung condition called post-tuberculosis tracheobronchial stenosis (PTTS). Imagine your airways - the tubes that carry air to your lungs - getting severely scarred and narrowed due to a past bout with tuberculosis. These two patients had tried previous treatments like balloon dilation (where a small balloon is inflated inside the narrowed airway to widen it) and using V-shaped stents (flexible supports placed in the airway to keep it open), but these methods didn’t provide lasting relief. In this innovative approach, doctors used L-shaped silicone stents specifically designed to fit in the affected parts of the patients’ airways. After placing these stents, regular checks showed remarkable improvements. The swelling in the airway lining reduced significantly, and the openings leading to the upper and lower parts of the lungs got wider. Chest X-rays (CT scans) even showed that the patient’s left lung was healing well. Three months later, the stents stayed firmly in place, and neither patient experienced any problems. Breathing became easier, lung function tests improved, and blood tests showed better oxygen levels. Seven months down the line, one patient continued to do extremely well, with the stent securely fixed and the chest scan showing good lung expansion. This groundbreaking study shows that using L-shaped silicone stents can effectively treat PTTS when other methods fail. Not only do they stay in place, preventing blockages, but they also safely and effectively alleviate narrowing of the airways. It’s the first time such L-shaped stents have been used successfully in PTTS patients, offering new hope for those facing similar challenges.
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  • 文章类型: Journal Article
    目的:先天性鼻泪管阻塞(CNLDO)是一种具有广泛病理的儿科疾病。如果未经治疗,这种情况可能会导致严重的并发症。CNLDO存在多种治疗选择,关于每个疾病亚组的最佳干预措施以及此类干预措施的最佳时机,目前仍在进行辩论。这项研究比较了硅胶管插管(STI)与探查和球囊扩张(BD)的成功率和失败率。
    方法:作者使用PubMed在文献中搜索相关文章,Scopus,科学网,和科克伦图书馆,直到2024年1月。使用RevMan5.4,作者使用风险比(RRs)和随机效应模型将STI的成功率和失败率与探查和BD进行了比较。此外,研究了单管插管(MCI)与双管插管(BCI)的并发症发生率。作者使用留一法检查有影响力的研究并解决异质性。
    结果:筛选过程产生了23篇符合条件的文章纳入作者综述。与探查相比,硅胶管插管有更高的机会解决CNLDO症状(RR=1.11;95%CI:1.04,1.20;P=0.004),而手术失败的风险较低(RR=0.48;95%CI:0.30,0.76;P=0.002]。与BCI相比,单管插管在手术成功和失败方面无统计学差异;然而,MCI具有较低的并发症风险(RR=0.68;95%CI:0.48,0.97;P=0.04)。此外,STI未显示与BD的任何显著差异。
    结论:MCI和BCI之间的成功/失败没有显着差异;单管的并发症较少。硅胶管插管在手术成功方面比探查更好,尤其是12个月以上的儿童,这表明它是老年CNLDO患者的首选干预措施。
    OBJECTIVE: Congenital nasolacrimal duct obstruction (CNLDO) is a pediatric disorder with a wide range of pathology. If untreated, the condition may end up with serious complications. Multiple treatment options for CNLDO exist throughout the literature, and there is an ongoing debate on the best intervention for each disease subgroup and the best timing of such interventions. This study compares the success and failure rates of silicone tube intubation (STI) against probing and balloon dilation (BD).
    METHODS: The authors searched the literature for relevant articles using PubMed, Scopus, web of Science, and Cochrane Library until January 2024. Using RevMan 5.4, the authors compared STI\'s success and failure rates to probing and BD using risk ratios (RRs) and a random-effect model. In addition, the complication rate of monocanalicular intubation (MCI) versus bicanalicular intubation (BCI) was investigated. The authors used the leave-one-out method to check for influential studies and to resolve heterogeneity.
    RESULTS: The screening process resulted in 23 eligible articles for inclusion in the authors\' review. Silicone tube intubation had a higher chance of resolving the symptoms of CNLDO than probing (RR = 1.11; 95% CI: 1.04, 1.20; P = 0.004) while having less risk of surgical failure (RR = 0.48; 95% CI: 0.30, 0.76; P = 0.002]. Monocanalicular intubation showed no statistically significant difference when compared with BCI in terms of surgical success and failure; however, MCI had a lower risk of complications (RR = 0.68; 95% CI: 0.48, 0.97; P = 0.04). In addition, STI did not demonstrate any significant difference from BD.
    CONCLUSIONS: There was no significant difference in success/failure between MCI and BCI; monocanalicular had fewer complications. Silicone tube intubation did better in terms of surgical success than probing, especially in children over 12 months, suggesting that it is the preferred intervention for older patients with CNLDO.
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  • 文章类型: Journal Article
    口外假体的寿命取决于其物理和机械性能以及用户维护。面对多重结果衡量标准,研究人员发现很难确定最合适的口外假体材料。这篇综合综述评估了最常用的口腔外假体材料,并定性评估了它们的寿命和功能。该研究旨在确定和解释影响寿命和功能的因素的当前更新结果。这篇综合综述总结并评估了常用口腔外颌面修复材料的性能差异。计划进行审查,重点关注与口腔外颌面假体的寿命和功能有关的所有因素。电子搜索涵盖PubMed中的英文文章,Scopus,谷歌学者,WebofScience,灰色文学还进行了手动搜索。六名作者参与了筛查。搜索引擎提取了1107条记录,纳入了88项研究进行定性和偏倚评估.有机硅是最常用的口腔颌面修复材料。热固化有机硅比在室温下固化的有机硅更具有颜色稳定性。额外的成分和加工技术影响假体的寿命。
    The longevity of an extraoral prosthesis depends on its physical and mechanical properties and user maintenance. Faced with multiple outcome measures, researchers find it difficult to determine the most appropriate extraoral prosthetic material. This comprehensive review evaluates the most used extraoral prosthesis materials and qualitatively assesses their longevity and function. The study aims to identify and interpret the results of current updates on the factors that affect longevity and functionality. This comprehensive review summarizes and evaluates differences in the properties of commonly used extraoral maxillofacial prosthetic materials. The review was planned to focus on all factors related to the longevity and function of the extraoral maxillofacial prosthetics. An electronic search covered English articles in PubMed, Scopus, Google Scholar, Web of Science, and grey literature. Manual searching was also performed. Six authors participated in the screening. Search engines extracted 1107 records, and 88 studies were included for qualitative and bias assessments. Silicones are the most frequently used extraoral maxillofacial prosthetic materials. Heat-cured silicones are more color-stable than those cured at room temperature. Additional ingredients and processing techniques affect prosthesis longevity.
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  • 文章类型: Journal Article
    环状和直链硅氧烷是由硅合成的化合物,由硅氧烷和具有有机侧链的氧[Si-O]单元的交替原子组成。最常见的环状硅氧烷是八甲基环四硅氧烷(D4),十甲基环五硅氧烷(D5),和十二甲基环己硅氧烷(D6),而最常见的直链硅氧烷是高分子量聚二甲基硅氧烷(PDMS)和低分子量挥发性直链硅氧烷,称为六甲基二硅氧烷(L2),八甲基三硅氧烷(L3),十甲基四硅氧烷(L4),十二甲基五硅氧烷(L5)。这些化合物(1)表现出低的皮肤毒性,(2)通常是惰性和非反应性的,和(3)与广泛的化学品兼容,提供有益的化学特性,包括以下:从皮肤洗掉或转移阻力,防晒系数(SPF)增强,清洁产品中的润肤)。由于这些属性,这些化合物被掺入多种消费品中用于皮肤,如化妆品和保健品,每年超过30万吨销往个人护理和消费品领域。由于它们在消费品中的广泛使用以及人体皮肤暴露的潜力,全面了解皮肤暴露后硅氧烷的皮肤吸收和总体命运非常重要。这篇综述总结了与最常用的硅氧烷物质的皮肤吸收/渗透以及命运相关的可用数据。
    Cyclic and linear siloxanes are compounds synthesized from silicon consisting of alternating atoms of silicone and oxygen [Si-O] units with organic side chains. The most common cyclic siloxanes are octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6), while the most common linear siloxanes are high molecular weight polydimethylsiloxanes (PDMS) and low molecular weight volatile linear siloxanes known as hexamethyldisiloxane (L2), octamethyltrisiloxane (L3), decamethyltetrasiloxane (L4), dodecamethylpentasiloxane (L5). These compounds (1) exhibit low dermal toxicity, (2) are generally inert and non-reactive, and (3) are compatible with a wide range of chemicals offering beneficial chemical properties which include the following: wash-off or transfer resistance from the skin, sun protection factor (SPF) enhancement, emolliency in cleaning products). Because of these properties, these compounds are incorporated into multiple consumer products for use on the skin, such as cosmetics and health-care products, with over 300,000 tons annually sold into the personal care and consumer products sector. Because of their widespread use in consumer products and potential for human dermal exposure, a comprehensive understanding of the dermal absorption and overall fate of siloxanes following dermal exposure is important. This review summarizes available data associated with the dermal absorption/penetration as well as fate of the most commonly used siloxane substances.
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  • 文章类型: Systematic Review
    目标:在烧伤的成年人中,非侵入性治疗是否能改善疼痛和烧伤疤痕瘙痒,弹性和血管化?干预期后是否仍有效果?
    方法:采用meta分析对随机试验进行系统评价。
    方法:有烧伤疤痕的成年人。
    方法:实验干预是非侵入性的(即,非手术或非药物)治疗应用于烧伤疤痕。
    方法:疼痛强度,瘙痒强度,弹性和血管化。
    结果:纳入了15项试验,涉及780名参与者。结果表明,按摩后0至10量表对疼痛强度有有益影响(MD-1.5,95%CI-1.8至-1.1),冲击波治疗(MD-0.8,95%CI-1.2至-0.4)和激光(MD-4.0,95%CI-6.0至-2.0)。结果表明,按摩后0至10量表对瘙痒强度有有益作用(MD-0.4,95%CI-0.7至-0.2),冲击波治疗(MD-1.3,95%CI-2.3至-0.3)和激光(MD-4.8,95%CI-6.1至-3.5)。按摩,冲击波疗法和硅胶对瘢痕弹性和血管形成的益处可忽略不计或不清楚。证据质量从低到中等不等。
    结论:在所有常用的治疗烧伤瘢痕的非侵入性疗法中,低到中等质量的证据表明,按摩,激光和冲击波治疗减轻疼痛和疤痕瘙痒的强度。低到中等质量的证据表明,按摩,冲击波疗法和硅胶对改善瘢痕弹性和血管形成的作用可忽略不计或不明确。
    背景:PROSPERO(CRD42021258336)。
    In adults with a burn injury, do non-invasive therapies improve pain and burn scar pruritus, elasticity and vascularisation? Are any effects maintained beyond the intervention period?
    Systematic review of randomised trials with meta-analyses.
    Adults with burn scars.
    The experimental intervention was a non-invasive (ie, non-surgical or non-pharmacological) therapy applied to the burn scar.
    Pain intensity, pruritus intensity, elasticity and vascularisation.
    Fifteen trials involving 780 participants were included. The results indicated a beneficial effect on pain intensity on a 0-to-10 scale after massage (MD -1.5, 95% CI -1.8 to -1.1), shockwave therapy (MD -0.8, 95% CI -1.2 to -0.4) and laser (MD -4.0, 95% CI -6.0 to -2.0). The results indicated a beneficial effect on pruritus intensity on a 0-to-10 scale after massage (MD -0.4, 95% CI -0.7 to -0.2), shockwave therapy (MD -1.3, 95% CI -2.3 to -0.3) and laser (MD -4.8, 95% CI -6.1 to -3.5). Massage, shockwave therapy and silicone produced negligible or unclear benefits on scar elasticity and vascularisation. The quality of evidence varied from low to moderate.
    Among all commonly used non-invasive therapies for the treatment of burn scars, low-to-moderate quality evidence indicated that massage, laser and shockwave therapy reduce pain and the intensity of scar pruritus. Low-to-moderate quality evidence suggested that massage, shockwave therapy and silicone have negligible or unclear effects for improving scar elasticity and vascularisation.
    PROSPERO (CRD42021258336).
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  • 文章类型: Journal Article
    在制造全口义齿的过程中,功能印象。文献研究表明,聚二甲基硅氧烷(缩合有机硅)尚未被美国牙科学校报道进行边界成型。因此,本文的目的是回顾使用实验室冷凝硅胶腻子进行边框成型时的功能印模技术。
    During the fabrication of a complete denture, functional impression is taken. Literature studies show that polydimethylsiloxane (condensation silicone) has not been reported by United States dental schools to perform border molding. Thus, the purpose of this article is to review the functional impression technique when border molding is performed with a laboratory condensation silicone putty.
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  • 文章类型: Meta-Analysis
    背景:研究近端指间(PIP)关节置换术的假体选择的长期结果的文献很少,大多数报告在分析中结合了适应症和潜在的病理。在这项研究中,我们的目标是比较硅胶,PIP关节成形术治疗原发性退行性骨关节炎(OA)中的焦碳和金属假体。方法:对1990年至2021年之间发表的科学文献进行了回顾。遵循系统审查和荟萃分析(PRISMA)指南的首选报告项目。对相关研究进行筛选并提取相应的数据。对临床结果(运动范围[ROM]和疼痛)的评估,对每个假体进行了并发症(再手术)和生存率.结果:纳入12项研究进行分析,共412个PIP关节。ROM为66.6°,金属为55.8°和46.4°,硅胶和热解碳植入物,分别。硅胶植入物在视觉模拟评分(1.2)上的疼痛评分最好,其次是热解碳(2.6)和金属(3.9)组。有机硅植入物的并发症发生率最低(11.3%),而热解碳的并发症发生率为18.5%,金属假体的并发症发生率为22.4%。三组之间的生存率没有显着差异。结论:我们的研究结果表明,对于原发性退行性OA患者,与其他植入物选择相比,使用硅树脂假体的PIP关节置换术可以提供更大的疼痛缓解,并发症发生率更低。证据级别:III级(治疗)。
    Background: Literature investigating the long-term outcomes of prosthesis options for proximal interphalangeal (PIP) joint arthroplasty is scarce, with most reports combining indications and underlying pathologies in analyses. In this study, we aim to compare silicone, pyrocarbon and metal prostheses in PIP joint arthroplasty for primary degenerative osteoarthritis (OA). Methods: A review of scientific literature published between 1990 and 2021 was conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Relevant studies were screened and the appropriate data was extracted. An evaluation of clinical outcomes (range of motion [ROM] and pain), complications (reoperation) and survival rates for each prosthesis was performed. Results: Twelve studies were included for analysis with a total of 412 PIP joints. ROM was 66.6°, 55.8° and 46.4° for metal, silicone and pyrocarbon implants, respectively. Silicone implants had the best pain score on the visual analogue scale (1.2) followed by the pyrocarbon (2.6) and metal (3.9) groups. Complication rates were lowest in silicone implants (11.3%) compared to 18.5% in pyrocarbon and 22.4% in metal prostheses. Survival did not differ significantly amongst the three groups. Conclusions: Our findings suggest that for patients with primary degenerative OA, PIP joint arthroplasty using a silicone prosthesis can provide greater pain relief with lower complication rates compared to other implant options. Level of Evidence: Level III (Therapeutic).
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  • 文章类型: Systematic Review
    放置在胸大肌(PM)肌肉下方的有机硅植入物或组织扩张器通常用于乳房重建。然而,PM插入的中断,这通常是外科手术过程中不可避免的一部分,已知会导致PM发病率,随后,同侧手臂的使用问题。在这次系统审查中,我们提供了有关基于硅胶的乳房重建对PM和同侧臂功能的影响的最新知识。通过PubMed进行了相关英语文献的搜索,并确定了十项符合条件的研究。报道隆胸的文章被接受,因为植入物插入技术类似于重建。问卷调查报告手臂的状态,用三维视频分析肩膀的运动范围,等距或等速测力计,超声剪切波弹性成像,容积MRI,PM纤维的肌电图和光学和电子显微镜用于评估PM和手臂状态。在PM下插入植入物,特别是当结合一些插入的解剖时,似乎与可测量的异常微观有关,成像,和动态测量结果。然而,肌肉的完整部分和可能的其他附近的肌肉结构能够补偿PM的丢失部分。因此,在日常生活中,植入物完全或部分插入PM下似乎对同侧上肢的功能没有影响或影响很小。
    Silicone implants or tissue expanders placed under the pectoralis major (PM) muscle are often used for breast reconstruction. However, the disruption of PM insertions, which is often an inevitable part of the surgical procedure, is known to cause PM morbidity and, subsequently, problems with the use of the ipsilateral arm. In this systematic review, we present current knowledge regarding the effect of submuscular silicone-based breast reconstruction on the function of PM and the ipsilateral arm. A search of the relevant English literature was performed through PubMed and ten eligible studies were identified. Articles reporting breast augmentation were accepted as the techniques of implant insertion are similar to reconstruction. Questionnaires reporting the status of the arm, analysis of the range of motion of the shoulder with 3-D video, isometric or isokinetic dynamometry, ultrasound shear-wave elastography, volumetric MRI, electromyography and light and electron microscopy of the PM fibers were used for the assessment of PM and arm status. The insertion of implants under the PM, especially when combined with dissection of some of its insertions, seems to be associated with measurable abnormal microscopic, imaging, and dynamometric findings. However, the intact part of the muscle and possibly other nearby muscular structures are able to compensate for the lost part of PM. Thus, the insertion of implants fully or partially under the PM seems to have no or little effect on the function of the ipsilateral upper limb in daily life.
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  • 文章类型: Meta-Analysis
    背景:目前,增生性瘢痕的治疗方法有很多种,其中压力疗法和硅胶疗法是非常常见和标准的疗法,但是它们是单独使用还是组合使用仍然存在争议。因此,本系统综述的目的是比较压力疗法和硅胶疗法(PTS)联合治疗与单纯压力疗法(PT)治疗增生性瘢痕的疗效和安全性,为临床医生提供信息,以便他们做出更好的决策.
    方法:通过检索PubMed,OvidMEDLINE,Embase,ScienceDirect,WebofScience,科克伦图书馆,Scopus,和谷歌学者数据库来评估疤痕分数(温哥华疤痕量表,VSS;视觉模拟刻度,VAS)和不利影响。
    结果:我们筛选了1270篇文章,纳入了6个RCT,包括228例患者。我们发现身高(MD=0.15,95CI0.10-0.21,p<0.01)和柔韧性(MD=0.35,95CI0.25-0.46,p<0.01)有显著差异,这两项指标均显示PTS组优于PT组。其他方面的结果,如VSS,血管,色素沉着,VAS,两组的不良反应相似。
    结论:在具有相似VSS和不良反应的肥厚性瘢痕的总体治疗效果上,PTS和PT之间没有显着差异,但是PTS可能对身高和柔韧性有潜在的好处。需要更多的样本量和合理的方法学质量的研究来证实我们的结论。证据级别IV本期刊要求作者为每篇文章分配一个级别的证据。对于这些循证医学评级的完整描述,请参阅目录或在线作者说明www。springer.com/00266.
    At present, there are many kinds of hypertrophic scar treatment methods, among which pressure therapy and silicone therapy are very common and standard therapies, but whether they are used alone or in combination is still controversial. Therefore, the purpose of this systematic review was to compare the efficacy and safety of the combination of pressure therapy and silicone therapy (PTS) with pressure therapy alone (PT) in the treatment of hypertrophic scars to provide clinicians with information so that they can make better decisions.
    Relevant randomized controlled trials (RCTs) were collected by searching PubMed, Ovid MEDLINE, Embase, ScienceDirect, Web of Science, The Cochrane Library, Scopus, and Google Scholar databases to assess scar scores (The Vancouver Scar Scale, VSS; Visual Analog Scale, VAS) and adverse effects.
    We screened 1270 articles and included 6 RCTs including 228 patients. We found that height (MD = 0.15, 95%CI 0.10-0.21, p < 0.01) and pliability (MD = 0.35, 95%CI 0.25-0.46, p <0.01) had a significant difference, these two measures showed that the PTS group was superior to the PT group. Results in other aspects, such as VSS, vascularity, pigmentation, VAS, and adverse effects were similar between the two groups.
    There was no significant difference between PTS and PT in the overall treatment efficacy of hypertrophic scars with similar VSS and adverse effects, but PTS might have potential benefits for height and pliability. Additional studies with larger sample size and sound methodological quality are needed to confirm our conclusions. Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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