revision surgery

翻修手术
  • 文章类型: Journal Article
    人工尿道括约肌(AUS)是男性压力性尿失禁(SUI)的有效治疗方法。然而,感染,侵蚀,机械故障,萎缩,和球囊恶化导致大约一半的患者在植入后10年发生设备故障。许多患者希望恢复尿失禁并需要进行翻修手术(RS),包括装置移除和同时或延迟植入。应对考虑RS的患者进行身体检查,并通过访谈检查是否有感染迹象。应使用膀胱镜检查评估尿道糜烂。如果有感染或侵蚀,所有的设备应该首先被删除,几个月后应该植入新设备。在RS期间,在尿道周围强烈粘附后,跨体袖带植入是一个安全的选择。可以在没有感染或侵蚀的情况下进行装置移除和同时植入。如果植入后已经过了很长时间,由于设备老化和退化,应更换整个设备;但是,如果时间很短,只有有缺陷的组件需要更换。术中评估尿道健康状况对于移除和植入装置是必要的。如果尿道是健康的,可以将新的袖带放置在与旧袖带移除相同的位置;但是,如果尿道不健康,袖带可以植入在更近/远的位置,或者可以选择跨体囊植入物。本文回顾了有关AUS男性患者复发性SUI的诊断和治疗策略的文献,并提出了AUS修订的流程图。
    Artificial urinary sphincters (AUS) are an effective treatment for male stress urinary incontinence (SUI). However, infection, erosion, mechanical failure, atrophy, and balloon deterioration cause device malfunction in approximately half of patients by 10 years after implantation. Many patients desire to regain urinary continence and require revision surgery (RS), including device removal and simultaneous or delayed implantation. Patients for whom RS is considered should be examined physically and by interview for signs of infection. Urethral erosion should be assessed using cystoscopy. If there is infection or erosion, all devices should be removed first, and a new device should be implanted several months later. During the RS, after strong adhesion around the urethra, transcorporal cuff implantation is a safe choice. Device removal and simultaneous implantation can be performed in the absence of infection or erosion. If a long time has passed since device implantation, the entire device should be replaced due to device aging and deterioration; however, if the time is short, only the defective component need be replaced. Intraoperative assessment of urethral health is necessary for device removal and implantation. If the urethra is healthy, a new cuff can be placed in the same position as the old cuff was removed from; however, if the urethra is unhealthy, the cuff can be implanted in a more proximal/distal position, or a transcorporal cuff implant may be chosen. This article reviews the literature on diagnostic and treatment strategies for recurrent SUI in male patients with AUS and proposes a flowchart for AUS revision.
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  • 文章类型: Journal Article
    全髋关节置换术(THA)是一种常见且成功的手术。然而,脱位仍然是固定轴承设计中植入物失败的重要原因。这项研究调查了双动植入物(DM)与固定轴承(FB)植入物相比对全因修正的影响,由于错位而进行的修订,接受原发性和翻修THA的患者的术后并发症和功能评分。
    进行了系统评价,包括根据PRISMA指南将DM与FB植入物在初级或修订THA中进行比较的研究。并在PROSPERO注册(IDCRD42023403736)。科克伦图书馆,Embase,MEDLINE,WebofScience,和Scopus从数据库开始到2023年3月12日进行了搜索。符合条件的研究使用ROBINS-I工具进行荟萃分析和偏倚风险评估。使用比值比评估治疗效果,并使用随机效应最大似然法汇总数据,在适当的地方。
    八个比较,纳入了涉及2810例DM植入物和3188例FB植入物的非随机研究.在初级THA中,对全因翻修的差异估计不准确(OR0.82,95%CI0.25~2.72),对糖尿病队列的脱位翻修有显著获益(OR0.08,95%CI0.02~0.28).在修订版THA中,DM队列在全因翻修(OR0.57,95%CI0.31-1.05)和脱位翻修(OR0.14,95%CI0.04-0.53)方面显示获益.DM植入物与较低的植入物脱位和感染发生率相关。由于报告限制,对功能结果的分析受到限制。未观察到假体内脱位。
    结果表明,当代DM设计可能有利于降低全因修订的风险,由于脱位而导致的翻修,以及中期随访时的术后并发症发生率。需要进一步的高质量前瞻性研究来评估这种设计的长期风险状况。特别是在修订的背景下。
    UNASSIGNED: Total hip arthroplasty (THA) is a common and successful operation. However, dislocation remains a significant cause of implant failure in fixed-bearing designs. This study investigated the effect of dual-mobility implants (DM) compared to fixed-bearing (FB) implants on all-cause revisions, revisions due to dislocation, post-operative complications and functional scores in patients undergoing primary and revision THA.
    UNASSIGNED: A systematic review was performed including studies that compared DM with FB implants in primary or revision THA according to PRISMA guidelines, and was registered in PROSPERO (ID CRD42023403736). The Cochrane Library, Embase, MEDLINE, Web of Science, and Scopus were searched from the time of database inception to March 12, 2023. Eligible studies underwent meta-analysis and risk of bias assessment using the ROBINS-I tool. Treatment effects were assessed using odds ratios and data were pooled using a random-effects maximum-likelihood, where appropriate.
    UNASSIGNED: Eight comparative, non-randomised studies involving 2810 DM implants and 3188 FB implants were included. In primary THA, there was an imprecise estimate of the difference in all-cause revision (OR 0.82, 95 % CI 0.25-2.72) and a significant benefit for the DM cohort in revision due to dislocation (OR 0.08, 95 % CI 0.02-0.28). In revision THA, the DM cohort showed benefit in all-cause revision (OR 0.57, 95 % CI 0.31-1.05) and revision due to dislocation (OR 0.14, 95 % CI 0.04-0.53). DM implants were associated with a lower incidence of implant dislocation and infection. The analysis of functional outcomes was limited due to reporting limitations. No intraprosthetic dislocations were observed.
    UNASSIGNED: The results suggest that contemporary DM designs may be advantageous in reducing the risk of all-cause revision, revision due to dislocation, and post-operative complication incidence at mid-term follow-up. Further high-quality prospective studies are needed to evaluate the long-term risk profile of this design, especially in the revision context.
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  • 文章类型: Journal Article
    目的:双移动性(DM)植入物由于其增加的稳定性,对翻修手术越来越感兴趣。这项系统评价的目的是比较DM与常规固定轴承(FB)植入物在翻修全髋关节置换术(r-THA)中的结果。
    方法:使用PubMed进行了全面搜索,Embase,2000年1月至2023年之间的MEDLINE数据库。成果措施包括因错位而重新修订,为其他原因重新修订,所有原因的重新修订,总并发症发生率,和功能结果衡量标准。非随机研究方法学指数(MINORS)评估工具用于评估方法学质量和偏倚风险。进行了汇总荟萃分析,使用卡方和希金斯I2检验评估异质性。在DM植入物和较大的股骨头(>36mm)FB植入物之间进行进一步的亚组分析。
    结果:共有13项研究符合最终纳入标准,包括5,004例r-THA臀部(2,108DM和2,896FB)。DM植入物由于脱位而重新翻修的几率明显降低(OR[比值比]0.38,P<0.001),无菌性松动(OR0.54,P=0.004),与FB植入物相比,所有原因的重新修订(OR0.55,P<0.001)。两组患者因假体周围感染(PJI)(OR0.99,P=0.94)或假体周围骨折(OR0.59,P=0.13)而重新翻修的几率差异无统计学意义。并发症总数显示出有利于DM植入物的优势(OR0.43,P<0.001)。在亚组分析中,DM和较大的股骨头FB植入物之间由于脱位而重新翻修的几率没有显着差异(OR0.69,P=0.11)。
    结论:根据现有文献,与FB植入物相比,DM植入物似乎是减少r-THA后脱位的有效方法,并发症发生率较低。然而,需要进一步的前瞻性随机对照试验(RCTs)和长期随访.
    BACKGROUND: Dual mobility (DM) implants have received increasing interest in revision surgery due to their increased stability. The aim of this systematic review was to compare outcomes of DM versus conventional fixed-bearing (FB) implants in revision total hip arthroplasty (rTHA).
    METHODS: A comprehensive search was performed using the PubMed, Embase, and MEDLINE databases between January 2000 and 2023. Outcome measures included rerevision due to dislocation, rerevision for other causes, all-cause rerevision, total complication rate, and functional outcome measures. The Methodological Index for Nonrandomized Studies assessment tool was used to evaluate methodological quality and the risk of bias. A pooled meta-analysis was conducted, with an assessment of heterogeneity using the Chi-square and Higgins I2 tests. A further subgroup analysis was performed between DM implants and larger femoral head (> 36 mm) FB implants.
    RESULTS: A total of 13 studies met the final inclusion criteria, with an overall number of 5,004 rTHA hips included (2,108 DM and 2,896 FB). The DM implants had significantly lower odds of rerevision due to dislocation (odds ratio [OR] 0.38, P < 0.001), aseptic loosening (OR 0.54, P = 0.004), and all-cause rerevision (OR 0.55, P < 0.001) compared to FB implants. No statistically significant difference was seen in the odds of rerevision due to periprosthetic joint infection (OR 0.99, P = 0.94) or periprosthetic fracture (OR 0.59, P = 0.13) between the 2 groups. The total number of complications showed an odds benefit in favor of DM implants (OR 0.43, P < 0.001). In the subgroup analysis, there was no significant difference in the odds of rerevision due to dislocation (OR 0.69, P = 0.11) between DM and larger femoral head FB implants.
    CONCLUSIONS: Based on current literature, it appears DM implants are an effective modality for reducing dislocation following rTHA with lower complication rates compared to FB implants. However, further prospective randomized controlled trials with longer term follow-up are required.
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  • 文章类型: Journal Article
    植入物相关感染(IRIs)是现代外科手术面临的重大挑战。这些感染的发生是由于病原体聚集和形成生物膜的能力,这对感染的诊断和后续治疗都提出了挑战。生物膜为病原体提供保护,使其免受宿主免疫反应和抗生素的侵害,使检测变得困难,并使单阶段和两阶段的修订程序复杂化。这篇叙述性综述研究了先进的化学抗生物膜技术,旨在改善IRIs中病原体的检测和鉴定。本综述中包含的文章选自PubMed等数据库,Scopus,MDPI和SpringerLink,该研究的重点是最近的研究,评估使用化学抗生物膜后微生物取样和培养的功效和提高的准确性。尽管一些抗生物膜化学预处理方法的成功应用已经取得了有希望的结果,主要在骨科和心血管外科,需要进一步的研究来优化和扩大其在临床环境中的常规使用。这是为了保证他们的安全,疗效和整合到诊断方案中。未来的研究应该集中在标准化这些技术并评估其在大规模临床试验中的有效性。这篇综述强调了跨学科合作在开发可靠诊断工具方面的重要性,并强调了需要创新方法来改善接受单阶段和两阶段修复手术治疗植入物相关感染的患者的预后。
    Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections.
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  • 文章类型: Journal Article
    据报道,关节镜肩袖修复(RCR)后的结果是成功的。手术后的深部感染(定义为涉及除皮肤和皮下组织以外的解剖结构的任何部分的感染)的发生率在0.03%至3.4%之间。本系统评价旨在探讨关节镜RCR术后感染的翻修手术的结果。分析了接受不同手术和抗生素治疗的患者的临床结果和根除率。共有5项研究有资格进行系统评价。共有146例患者接受了治疗和评估,其中71人(48%)和75人(52%)接受了关节镜和开放手术来控制感染,分别。最常见的致病菌是痤疮切杆菌(50.4%)。两项研究报告了术前和术后ASES评分和Constant-Murley评分(CMS),并且在手术后发现统计学上的显着改善(两者均p<0.001)。在总共138例患者中观察到根除(94.5%);关节镜和开放翻修手术之间没有发现差异(92.8%和96%,分别,p=0.90)。静脉抗生素治疗的频率加权平均持续时间为6.6±5.4天,而抗生素治疗的总体平均持续时间,考虑静脉和口服给药,为43.5±40天。关节镜RCR接受翻修手术后感染的患者根除率很高。可以预期肩部功能的显著改善和较少的残余疼痛。
    The outcomes after arthroscopic rotator cuff repair (RCR) have been reported to be successful. The incidence of deep infections (defined as an infection involving any part of the anatomy other than the skin and subcutaneous tissue) after surgery ranges between 0.03% and 3.4%. This systematic review aims to investigate the outcomes of revision surgery for infection following arthroscopic RCR. Clinical outcomes and eradication rates among patients treated with different surgical and antibiotic therapies are analyzed. A total of five studies were eligible for systematic review. A total of 146 patients were treated and evaluated, of whom 71 (48%) and 75 (52%) underwent arthroscopic and open surgery to manage the infection, respectively. The most common causative bacterium was Cutibacterium acnes (50.4%). Two studies reported the pre-and postoperative ASES score and Constant-Murley score (CMS), and a statistically significant improvement was found after surgery (p < 0.001 for both). Eradication was observed in a total of 138 patients (94.5%); no difference was found between arthroscopic and open revision surgery (92.8% and 96%, respectively, p = 0.90). The frequency-weighted mean duration of the intravenous antibiotic therapy was 6.6 ± 5.4 days, while the overall mean duration of antibiotic therapy, considering intravenous and oral administration, was 43.5 ± 40 days. Patients with infection following arthroscopic RCR undergoing revision surgery experienced a high rate of eradication. A significant improvement in shoulder functionality and less residual pain can be expected.
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  • 文章类型: Journal Article
    跟腱断裂是运动期间常见的损伤,男性发病率较高,尽管对伤害管理后的性别特异性风险因素或结局了解甚少。这项横断面临床研究和系统评价旨在检查干预后性别特异性跟腱断裂的发生率和结果。这项研究包括2011-2021年之间持续破裂的患者,年龄≥18岁,至少有六个月的随访,并评估了年龄,性别,体育参与,损伤机制,以及术后并发症和翻修。分别,PubMed的系统文献综述,EMBASE,并进行了Cochrane数据库。共有705名男性和158名女性患者被纳入这项回顾性研究。71.1%的男性和52.5%的女性持续了与运动相关的破裂(p<0.001)。运动参与与修订率呈正相关(系数=0.09,p=0.02)。共有21项研究,有250,907名患者(男性为87,514名,35,792名女性)被纳入系统评价。所有研究都显示男性ATR的发病率增加。女性的功能结果更差,女性是术后并发症和需要翻修手术的独立危险因素。这项研究表明,男性与运动相关的ATR的发病率高于女性。可能与他们较高的球类运动参与度有关。尽管回顾性分析没有发现并发症或翻修率的显著差异,系统评价显示功能效果较差,与男性相比,女性术后并发症和翻修手术的可能性增加。临床证据水平:III级。
    Achilles tendon ruptures are common injuries typically sustained during sport with higher incidence in men, though little is understood regarding sex-specific risk factors or outcomes following injury management. This cross-sectional clinical study and systematic review aimed to examine sex-specific Achilles tendon rupture incidence and outcomes following intervention. This study included patients who sustained a rupture between 2011-2021, were ≥18 years old, and who had a minimum follow-up of at least six months, and evaluated age, sex, sport involvement, mechanism of injury, and postoperative complications and revision. Separately, a systematic literature review in the PubMed, EMBASE, and Cochrane databases was performed. A total of 705 male and 158 female patients were included in this retrospective study. 71.1% of men and 52.5% of women sustained a sports-related rupture (p < .001), with sport involvement demonstrating a positive correlation with revision rate (coefficient = 0.09, p = .02). A total of 21 studies with 250,907 patients (87,514 male, 35,792 female) were included in the systematic review. All studies revealed an increased incidence of ATR in men. Functional outcomes were worse in women, and female sex was an independent risk factor for postoperative complications and need for revision surgery. This study demonstrated a higher incidence of sports-related ATR in men than women, likely related to their higher ball sport participation. Although the retrospective analysis did not find a significant difference in complication or revision rates, the systematic review demonstrates poorer functional outcomes, with increased likelihood for postoperative complication and revision surgery in women as compared to men.
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  • 文章类型: Journal Article
    (1)背景:髋部假瘤是一种无菌的,与全髋关节置换术相关的非肿瘤软组织肿块。假瘤可能模仿软组织肿瘤或感染,因此鉴别诊断至关重要,建议进行活检。这项研究的目的是比较一阶段和两阶段手术之间的并发症和功能结果。(2)方法:我们回顾性分析了在我们机构手术治疗的21例与髋关节假体相关的“假瘤”患者(8例男性,13名女性,平均年龄69岁)。一期翻修10例,二期翻修10例,仅切除1例。并发症分为主要和次要,并使用Harris髋关节评分(HHS)评估功能结果。(3)结果:5例患者(24%)报告了主要并发症。所有并发症的生存率为75%。5年总生存率为95%。平均HHS范围从35术前到75术后,突出显示在所有情况下改善的功能结果。我们记录了一阶段和两阶段手术之间并发症或功能结局的差异。(4)结论:根据我们的经验,对于有严重骨缺损和较大假瘤的病例,优选两阶段手术入路.定制的3D打印假体的使用正在增加,这也是更喜欢两阶段翻修的另一个原因。
    (1) Background: A pseudotumor of the hip is a sterile, non-neoplastic soft tissue mass associated with total hip arthroplasties. Pseudotumors may mimic soft tissue tumors or infections, and thus a differential diagnosis is crucial, and biopsy is recommended. The purpose of this study was to compare the complications and functional results between one-stage and two-stage procedures. (2) Methods: We retrospectively analyzed 21 patients surgically treated at our institution with \"pseudotumors\" associated with hip prosthesis (8 male, 13 female with a mean age of 69 years). One-stage revision was performed in 10 cases and two-stage reversion in 10, with excision only in 1 case. Complications were classified as major and minor and functional results assessed using the Harris Hip Score (HHS). (3) Results: Five patients (24%) reported major complications. The survival rate for all complications was 75%. The overall survival rate was 95% at 5 years. The mean HHS ranged from 35 pre-op to 75 post-op, highlighting improved functional results in all cases. We recorded no differences in complications or functional outcomes between the one- and two-stage procedures. (4) Conclusions: In our experience, the two-stage surgical approach is preferable in cases with major bone defects and larger pseudotumor sizes. The use of custom-made 3D-printed prostheses is increasing and is a further reason to prefer two-stage revision.
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  • 文章类型: Journal Article
    外上髁炎是一般人群中肘部疼痛的常见原因。它被认为是一种常见的伸肌起源的退行性肌腱病,被认为是多因素的,涉及与某些生理和解剖危险因素相关的重复性微创伤因素。
    初始治疗通常包括保守治疗措施的组合,在12-18个月内有高达90%的成功率。手术治疗保留用于顽固性疾病;传统上涉及普通伸肌起源的开放性手术清创,据报道成功率大于90%。
    手术治疗失败可能是多因素的,在确定最佳管理方面存在挑战。残留症状可能是由于初始诊断不正确,不充分的外科清创,作为初始手术和/或其他患者相关和医师相关因素的并发症的新病理。甚至更多的挑战是病因学可能是由于列出的因素的组合。
    在这篇评论中,我们回顾了Morrey首次提出的评估LE手术治疗失败的分类方案,并根据资深作者的经验对该分类系统进行了扩展。我们介绍了资深作者首选的系统方法来评估和管理这些患者,以及资深作者用于解决这些患者中最常见的手术失败病因的抢救手术技术。
    UNASSIGNED: Lateral epicondylitis is a common cause of elbow pain in the general population. It is recognized as a degenerative tendinopathy of the common extensor origin believed to be multifactorial, involving elements of repetitive microtrauma associated with certain physiologic and anatomic risk factors.
    UNASSIGNED: Initial treatment typically involves a combination of conservative treatment measures, with up to 90% success at 12-18 months. Surgical treatment is reserved for recalcitrant disease; traditionally involving open surgical débridement of the common extensor origin with reported success rates greater than 90%.
    UNASSIGNED: Failure of surgical treatment can be multifactorial and present a challenge in determining the optimum management. Residual symptoms may be due to an incorrect initial diagnosis, inadequate surgical débridement, new pathology as a complication of the initial surgery and/or other patient-related and physician- related factors. Even more of a challenge is the possibility that etiology can be due to a combination of listed factors.
    UNASSIGNED: In this review, we review the classification scheme for evaluating failed surgical treatment of LE first proposed by Morrey and expand on this classification system based on the senior author\'s experience. We present the senior author\'s preferred systematic approach to evaluation and management of these patients, as well as a salvage surgery technique used by the senior author to address the most common etiologies of surgical failure in these patients.
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  • 文章类型: Journal Article
    大约90%接受关节镜肩袖修复(RCR)的患者对手术后的疼痛程度和功能感到满意。然而,一部分患者出现持续症状,需要进行翻修手术.需要进行翻修手术的RCR失败的术前风险因素尚未明确定义。
    为了(1)确定需要进行翻修手术的RCR失败率和(2)确定翻修手术的风险因素,这将有助于外科医生确定RCR失败风险最大的患者。
    系统评价和荟萃分析;证据水平,4.
    根据PRISMA(系统评价和荟萃分析的首选报告项目)指南进行系统评价和荟萃分析。最初的搜索结果是3158个标题,对533篇全文文章进行了资格评估。共有10项研究符合以下纳入标准:(1)人体临床研究,(2)关节镜下RCR,(3)原创性临床研究,(4)评估术前翻修的危险因素。
    经过全文审查,在10项研究中,共记录并分析了16个危险因素.皮质类固醇注射是翻修手术最一致的危险因素,在4项研究中的4项达到统计学意义,其次是工人的补偿状况(2/3的研究)。接受皮质类固醇注射的患者进行翻修手术的风险增加了47%(比值比,1.44[95%CI,1.36-1.52])。有工人补偿的患者有合并的翻修手术风险增加133%(比值比,2.33[95%CI,2.09-2.60])。年龄,吸烟状况,糖尿病,在一半的分析研究中,肥胖被发现是危险因素。
    皮质类固醇注射液,无论注射频率如何,根据定性分析和汇总分析,在文献中发现工人的薪酬状况是显著的风险因素。外科医生应通过考虑皮质类固醇注射史来确定关节镜RCR的理想人选。不管频率如何,以及患者的保险状况。
    UNASSIGNED: Approximately 90% of patients who undergo arthroscopic rotator cuff repair (RCR) are satisfied with their pain levels and function after surgery. However, a subset of patients experience continued symptoms that warrant revision surgery. Preoperative risk factors for RCR failure requiring revision surgery have not been clearly defined.
    UNASSIGNED: To (1) determine the rate of RCR failure requiring revision surgery and (2) identify risk factors for revision surgery, which will help surgeons to determine patients who are at the greatest risk for RCR failure.
    UNASSIGNED: Systematic review and meta-analysis; Level of evidence, 4.
    UNASSIGNED: A systematic review and meta-analysis in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were performed. The initial search resulted in 3158 titles, and 533 full-text articles were assessed for eligibility. A total of 10 studies met the following inclusion criteria: (1) human clinical studies, (2) arthroscopic RCR, (3) original clinical research, and (4) evaluation of preoperative risk factors for revision.
    UNASSIGNED: After a full-text review, a total of 16 risk factors were recorded and analyzed across 10 studies. Corticosteroid injection was the most consistent risk factor for revision surgery, reaching statistical significance in 4 of 4 studies, followed by workers\' compensation status (2/3 studies). Patients with corticosteroid injections had a pooled increased risk of revision surgery by 47% (odds ratio, 1.44 [95% CI, 1.36-1.52]). Patients with workers\' compensation had a pooled increased risk of revision surgery by 133% (odds ratio, 2.33 [95% CI, 2.09-2.60]). Age, smoking status, diabetes, and obesity were found to be risk factors in half of the analyzed studies.
    UNASSIGNED: Corticosteroid injections, regardless of the frequency of injections, and workers\' compensation status were found to be significant risk factors across the literature based on qualitative analysis and pooled analysis. Surgeons should determine ideal candidates for arthroscopic RCR by accounting for corticosteroid injection history, regardless of the frequency, and insurance status of the patient.
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  • 文章类型: Meta-Analysis
    背景:尽管与髂骨植骨(ICBG)的成功融合率,供体部位的发病率和增加的手术时间仍然是一个相当大的限制,并推动寻找替代品。在这次系统审查中,将额外补充细胞的移植物与用于脊柱关节固定术的ICBG进行了比较。我们比较了安全性,疗效和长期结果,从而为整形外科医生就这一快速发展的领域做出明智的选择提供了当前和相关的证据。
    方法:根据PRISMA指南,由两名独立审稿人使用PubMed对截至2023年3月1日发表的文章进行了电子文献检索,EMBASE和Cochrane中央对照试验登记册。不包括细胞同种异体移植物。提取以下数据:患者人数,移植物的类型,融合评估方法,随访持续时间,融合率,临床结果和并发症。使用Cochrane开发的用于评估随机和非随机研究偏倚的偏倚的风险2(RoB-2)工具和非随机研究偏倚风险(ROBINS)工具评估方法学证据质量(MQOE)。
    结果:10项研究符合纳入标准,包括465名患者。每个研究的平均患者人数为43.8(stddev。28.81,范围12-100)。两项研究表明,与ICBG相比,基于细胞的治疗在融合率方面更加成功。然而,其余8人表现出模棱两可的结果.没有研究发现基于细胞的疗法较差。在三项关注退行性队列的研究中,两组之间没有差异。两组之间的功能结果评分没有差异。在整个研究中使用了许多用于基于细胞的移植物的不同制备技术。
    结论:基于细胞的治疗在脊柱融合术中提供了一种有希望的替代ICBG的方法,这可以帮助降低患者的相关发病率。这篇综述发现,基于细胞的治疗不劣于the骨移植,可以为患者提供一种并发症少,术后疼痛减轻的替代治疗选择。然而,迄今为止的文献受到细胞制备和移植过程的异质性的限制。需要对细胞制备过程采用统一方法的未来研究来充分描述该技术的潜在优势。
    BACKGROUND: Despite successful fusion rates with iliac crest bone graft (ICBG), donor-site morbidity and increased operating time remain a considerable limitation and drive the search for alternatives. In this systematic review, grafts with additional cellular supplementation were compared with ICBG for spinal arthrodesis. We compared safety, efficacy and long-term outcomes, thus providing the current and relevant evidence for orthopaedic surgeons to make informed choices regarding this rapidly developing field.
    METHODS: An electronic literature search was conducted according to the PRISMA guidelines by two independent reviewers for articles published up to 1st March 2023 using PubMed, EMBASE and the Cochrane Central Register of Controlled Trial. Cellular allografts were not included. The following data were extracted: Number of patients, type of graft, fusion assessment method, follow-up duration, fusion rates, clinical outcomes and complications. The methodological quality of evidence (MQOE) was assessed using the Risk of Bias 2 (RoB-2) tool and Risk of Bias In Non-Randomised Studies (ROBINS) tool developed by Cochrane for evaluating bias in randomised and non-randomised studies.
    RESULTS: Ten studies fulfiled the inclusion criteria, including 465 patients. The mean number of patients per study was 43.8 (std dev. 28.81, range 12-100). Two studies demonstrated cell-based therapy to be significantly more successful in terms of fusion rates compared to ICBG. However, the remaining eight demonstrated equivocal results. No study found that cell-based therapy was inferior. No difference was seen between the two groups in three studies who focused on degenerative cohorts. No difference in functional outcome scores was seen between the groups. A number of different preparation techniques for cell-based grafts were used throughout the studies.
    CONCLUSIONS: Cell-based therapy offers a promising alternative to ICBG in spinal fusion surgery, which could help reduce the associated morbidity to patients. This review found that cell-based therapy is non-inferior to iliac crest bone graft and may offer patients an alternative treatment option with fewer complications and reduced post-operative pain. However, the literature to date is limited by heterogeneity of the cell preparation and grafting process. Future research with a unified approach to the cell preparation process is required to fully delineate the potential advantages of this technology.
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