PDF(Pubmed)
Abstract：
Implant-related infections (IRIs) represent a significant challenge to modern surgery. The occurrence of these infections is due to the ability of pathogens to aggregate and form biofilms, which presents a challenge to both the diagnosis and subsequent treatment of the infection. Biofilms provide pathogens with protection from the host immune response and antibiotics, making detection difficult and complicating both single-stage and two-stage revision procedures. This narrative review examines advanced chemical antibiofilm techniques with the aim of improving the detection and identification of pathogens in IRIs. The articles included in this review were selected from databases such as PubMed, Scopus, MDPI and SpringerLink, which focus on recent studies evaluating the efficacy and enhanced accuracy of microbiological sampling and culture following the use of chemical antibiofilm. Although promising results have been achieved with the successful application of some antibiofilm chemical pre-treatment methods, mainly in orthopedics and in cardiovascular surgery, further research is required to optimize and expand their routine use in the clinical setting. This is necessary to ensure their safety, efficacy and integration into diagnostic protocols. Future studies should focus on standardizing these techniques and evaluating their effectiveness in large-scale clinical trials. This review emphasizes the importance of interdisciplinary collaboration in developing reliable diagnostic tools and highlights the need for innovative approaches to improve outcomes for patients undergoing both single-stage and two-stage revision surgery for implant-related infections.
摘要：
植入物相关感染（IRIs）是现代外科手术面临的重大挑战。这些感染的发生是由于病原体聚集和形成生物膜的能力，这对感染的诊断和后续治疗都提出了挑战。生物膜为病原体提供保护，使其免受宿主免疫反应和抗生素的侵害，使检测变得困难，并使单阶段和两阶段的修订程序复杂化。这篇叙述性综述研究了先进的化学抗生物膜技术，旨在改善IRIs中病原体的检测和鉴定。本综述中包含的文章选自PubMed等数据库，Scopus,MDPI和SpringerLink,该研究的重点是最近的研究，评估使用化学抗生物膜后微生物取样和培养的功效和提高的准确性。尽管一些抗生物膜化学预处理方法的成功应用已经取得了有希望的结果，主要在骨科和心血管外科，需要进一步的研究来优化和扩大其在临床环境中的常规使用。这是为了保证他们的安全，疗效和整合到诊断方案中。未来的研究应该集中在标准化这些技术并评估其在大规模临床试验中的有效性。这篇综述强调了跨学科合作在开发可靠诊断工具方面的重要性，并强调了需要创新方法来改善接受单阶段和两阶段修复手术治疗植入物相关感染的患者的预后。
