■意外或故意摄入百草枯导致许多局部和全身影响,死亡率很高。来自印度北部的数据有限,我们的目标是研究呈现的范围,给予治疗,以及它与三级护理环境中结果的关系。
■这项回顾性观察研究是在伦理批准和人口统计学数据后进行的,临床特征,演示的持续时间,器官受累,肾脏替代疗法(RRT),管理,并收集了结果。通过计算平均值和标准偏差(SD)进行统计学分析。将卡方(χ2)检验应用于分类变量,当预期频率小于5时使用Fisher精确检验。
■研究人群包括91名男性(84%)和18名女性患者。109名患者中,13例存活(12%),88%有致命结局。近92%的患者属于农村背景,和68%的年轻(<30岁)年龄组。年龄,性别,职业,和服用量与死亡率没有任何显著关系。代谢性酸中毒患者(58.7%),肾脏改变(75.2%),出现时肝功能(62.3%)与死亡率有统计学显著关系。与未存活的患者相比,存活的患者的就诊持续时间明显较少(17.26±17.23,中位数14小时vs80.18±90.07,中位数48小时)。肾脏替代疗法(n=57)与死亡率无关,而接受血液灌流(HP)的患者中有36%存活(p=0.03)。
■治疗应尽早开始,因为治疗的持续时间与结果有显著关联。目前没有解毒剂可用。支持性治疗包括氧合,免疫抑制,抗氧化剂,RRT,和HP(只要有可用的资源)。
■GoyalP,GautamPL,SharmaS,保罗·G,Taneja五世,MonaA.百草枯中毒表现研究,严重性,三级护理医院的管理和结果:乌云中是否有银色衬里?印度JCritCareMed2024;28(8):741-747。
UNASSIGNED: Accidental or intentional ingestion of paraquat leads to many local and systemic effects and the mortality rate is very high. There is limited data from North India and our objectives were to
study the spectrum of presentation, treatment given, and its relation with outcome in a tertiary care setting.
UNASSIGNED: This retrospective observational
study was conducted after ethical approval and data regarding demography, clinical features, duration of presentation, organ involvement, renal replacement therapy (RRT), management, and outcome was collected. Statistical analysis was done by calculating mean and standard deviation (SD). Chi-square (χ2) test was applied to categorical variables and the Fisher exact test was used when the expected frequency was less than 5.
UNASSIGNED: The
study population consisted of 91 male (84%) and 18 female patients. Out of 109 patients, 13 survived (12%) and 88% had a fatal outcome. Nearly 92% of patients belonged to rural background, and 68% were of younger (<30 years) age group. Age, gender, occupation, and amount taken did not have any significant relation with mortality. Patients having metabolic acidosis (58.7%), altered renal (75.2%), and hepatic function (62.3%) at presentation had a statistically significant relation with mortality. Duration of presentation was significantly lesser in patients who survived (17.26 ± 17.23, median 14 hours vs 80.18 ± 90.07, median 48 hours) compared to patients who did not survive. Renal replacement therapy (n = 57) had no relation with mortality whereas 36% of the patients who received hemoperfusion (HP) survived (p = 0.03).
UNASSIGNED: Treatment should be started early as the duration of the presentation has a significant association with the outcome. Currently there is no antidote available. Supportive treatment includes oxygenation, immunosuppression, antioxidants, RRT, and HP wherever the resources are available.
UNASSIGNED: Goyal P, Gautam PL, Sharma S, Paul G, Taneja V, Mona A. A
Study of Paraquat Poisoning Presentation, Severity, Management and Outcome in a Tertiary Care Hospital: Is There a Silver Lining in the Dark Clouds? Indian J Crit Care Med 2024;28(8):741-747.