Abstract：
Background Several studies have reported that psoriasis has a positive correlation with type 2 diabetes mellitus (DM). Understanding the risk of psoriasis in diabetic patients is significant because it allows for early intervention and potential insights into the common pathways between the two conditions. Objectives We analysed the risk of psoriasis according to the estimated glomerular filtration rate (eGFR) and proteinuria level in DM patients using Korean population-based data. Methods This study was a retrospective cohort study using data collected from the country in the form of exploratory data analysis. A total of 927,234 participants diagnosed with DM were enrolled. Patients under the age of 20 with existing psoriasis or psoriasis developed within 1 year and missing data were excluded. The development of psoriasis was the primary outcome within a follow-up period of 7.83 ± 1.68 years. Results Of the 840,395 final participants, 28,010 (3.33%) patients developed psoriasis. In multivariate-adjusted Cox proportional hazards regression models, the DM patients with eGFR < 30 had a higher risk of psoriasis after adjustment (eGFR 60-90, hazard ratio [HR] 1 (Ref.); eGFR < 30, HR 1.173, 95% CI 1.089-1.264). In addition, there was an increased psoriatic risk of patients with DM and proteinuria after adjustment (negative, HR 1 (Ref.); 2+, HR 1.164, 95% CI 1.080-1.254; 3+, HR 1.433, 95% CI 1.273-1.613; 4+, HR 1.508, 95% CI 1.177-1.931). Limitations The severity of psoriasis was not measured since the occurrence of psoriasis was the outcome. Details of oral hypoglycaemic agents such as type and dose were not investigated. Conclusion This study showed that a decrease in eGFR and aggravation of proteinuria increase the risk of psoriasis in diabetic patients. Therefore, by using eGFR and proteinuria as predictive risk factors of psoriasis in DM patients, early and proactive treatment may play a vital role in managing diabetic patients.
摘要：
背景多项研究报道银屑病与2型糖尿病（DM）呈正相关。了解糖尿病患者牛皮癣的风险很重要，因为它允许早期干预和潜在的洞察两种情况之间的共同途径。目的我们使用韩国人群数据，根据估计的肾小球滤过率（eGFR）和糖尿病患者的蛋白尿水平分析了银屑病的风险。方法本研究为回顾性队列研究,以探索性数据分析的形式,使用从国内收集的数据。共纳入927,234名被诊断为DM的参与者。年龄在20岁以下患有现有银屑病或银屑病的患者在1年内发展并且缺失数据被排除。在7.83±1.68年的随访期内，银屑病的发展是主要结果。结果在840,395名最终参与者中，28,010例（3.33%）患者发生银屑病。在多变量调整后的Cox比例风险回归模型中，校正后，eGFR<30的DM患者患银屑病的风险更高（eGFR60-90，风险比[HR]1（Ref.)；eGFR<30，HR1.173，95%CI1.089-1.264）。此外,调整后糖尿病和蛋白尿患者的银屑病风险增加(阴性，HR1（参考)；2+，HR1.164，95%CI1.080-1.254；3+，HR1.433，95%CI1.273-1.613；4+，HR1.508，95%CI1.177-1.931）。局限性未测量银屑病的严重程度,因为银屑病的发生是结果。没有研究口服降糖药的细节，如类型和剂量。结论本研究表明，eGFR的降低和蛋白尿的加重会增加糖尿病患者银屑病的风险。因此,通过使用eGFR和蛋白尿作为DM患者银屑病的预测危险因素，早期和积极的治疗可能在糖尿病患者的治疗中起着至关重要的作用.
