脉冲染料激光(PDL)是最常用的葡萄酒色斑(PWS)方法;然而,没有研究报告PDL的安全性.这篇综述旨在收集和总结相关文献中报道的并发症,评估PDL治疗PWS的并发症发生率,并探讨相关影响因素。进行了系统评价和荟萃分析,以搜索PubMed中的相关研究。Embase,和Cochrane图书馆,直到2022年8月。两名评审员独立评估了纳入研究的偏倚风险。Stata软件17.0版用于分析。文献报道的所有并发症分为急性期并发症和长期并发症。总体上是合并紫癜,水肿,结壳,起泡,色素沉着过度,色素沉着减退,结疤率为98.3%,97.6%,21.5%,8.7%,12.8%,0.9%,和0.2%,分别。尽管发现急性不良反应很常见,长期永久性并发症的发生频率明显较低,疤痕的发生比最初想象的要低得多。这表明治疗后有效的防护措施对于预防瘢痕形成非常重要。总的来说,PWS的PDL治疗显示出高水平的安全性和引起长期并发症的低机率。
Pulsed dye laser (PDL) is the most commonly used method for port-wine stain (PWS); however, no studies have reported the safety of PDL. This
review aimed to collect and summarize complications reported in relevant literature, assess complication rates in treating PWS with PDL, and explore the relevant influencing factors. A systematic
review and meta-analysis were conducted to search for related studies in PubMed, Embase, and the Cochrane Library until August 2022. Two reviewers independently evaluated the risk of bias of included studies. Stata Software version 17.0 was used for the analysis. All complications reported in the literature are divided into acute phase complications and long-term complications. Overall pooled purpura, edema, crusting, blistering, hyperpigmentation, hypopigmentation, and scarring rates were 98.3%, 97.6%, 21.5%, 8.7%, 12.8%, 0.9%, and 0.2%, respectively. Although the acute adverse reactions were found to be common, the long-term permanent complications clearly have a lower frequency, and the occurrence of scarring is much lower than that initially thought. This indicates that effective protective measures after treatment are very important for preventing scar formation. Overall, PDL treatment for PWS shows a high level of safety and low chances of causing long-term complications.