PDF(Pubmed)
Abstract：
UNASSIGNED: The role of lasers in the treatment of standard therapy-resistant inflammatory dermatoses and connective tissue disorders has been controversial and evidence supporting the role of lasers in this setting is scarce.
UNASSIGNED: To assess the efficacy of lasers in the management of inflammatory dermatoses and connective tissue disorders (CTD).
UNASSIGNED: A retrospective case review of all inflammatory dermatoses/connective tissue diseases treated in a tertiary laser clinic between March 2010 and 2020 was undertaken.
UNASSIGNED: A total of 60 cases (48 = female) were included and the average age was 51 years (range 21 to 74). The following conditions were treated: scleroderma n = 22 (37%), granuloma faciale n = 10 (17%), sarcoidosis n = 8 (13%), discoid lupus erythematosus n = 7 (12%), and systemic lupus erythematosus n = 2 (3%). Other diagnoses included necrobiosis lipoidica, pyoderma vegetans, hypertrophic lichen planus, and dermatomyositis. The most common type of laser used was pulsed dye laser (PDL) in n = 41 (68%) cases. Eight (13%) patients received treatment with the carbon dioxide (CO2) laser. The most common site treated was the face. A good response with a marked reduction of signs was seen in 62% of patients while 10% of the patients did not respond to laser treatment. Self-limiting complications included purpura and hyperpigmentation.
UNASSIGNED: Lack of objective assessment and outcome measures.
UNASSIGNED: This is the largest cohort of patients to have undergone laser treatment for inflammatory dermatoses/connective tissue disease. Based on this retrospective review, we conclude that lasers can be a useful adjunct in the management of otherwise difficult-to-treat selected inflammatory and connective tissue diseases.
UNASSIGNED: To assess the efficacy of lasers in the management of inflammatory dermatoses and connective tissue disorders (CTD).
UNASSIGNED: A retrospective case review of all inflammatory dermatoses/connective tissue diseases treated in a tertiary laser clinic between March 2010 and 2020 was undertaken.
UNASSIGNED: A total of 60 cases (48 = female) were included and the average age was 51 years (range 21 to 74). The following conditions were treated: scleroderma n = 22 (37%), granuloma faciale n = 10 (17%), sarcoidosis n = 8 (13%), discoid lupus erythematosus n = 7 (12%), and systemic lupus erythematosus n = 2 (3%). Other diagnoses included necrobiosis lipoidica, pyoderma vegetans, hypertrophic lichen planus, and dermatomyositis. The most common type of laser used was pulsed dye laser (PDL) in n = 41 (68%) cases. Eight (13%) patients received treatment with the carbon dioxide (CO2) laser. The most common site treated was the face. A good response with a marked reduction of signs was seen in 62% of patients while 10% of the patients did not respond to laser treatment. Self-limiting complications included purpura and hyperpigmentation.
UNASSIGNED: Lack of objective assessment and outcome measures.
UNASSIGNED: This is the largest cohort of patients to have undergone laser treatment for inflammatory dermatoses/connective tissue disease. Based on this retrospective review, we conclude that lasers can be a useful adjunct in the management of otherwise difficult-to-treat selected inflammatory and connective tissue diseases.
摘要：
■激光在治疗标准治疗抵抗的炎症性皮肤病和结缔组织疾病中的作用一直存在争议，支持激光在这种情况下的作用的证据很少。
■评估激光治疗炎症性皮肤病和结缔组织疾病（CTD）的疗效。
■对2010年3月至2020年在三级激光诊所治疗的所有炎症性皮肤病/结缔组织疾病进行回顾性病例回顾。
■共纳入60例（48=女性），平均年龄为51岁（范围为21至74）。治疗以下疾病：硬皮病n=22（37％），面部肉芽肿n=10（17%），结节病n=8（13%），盘状红斑狼疮n=7（12％），和系统性红斑狼疮n=2（3％）。其他诊断包括脂肪坏死病，脓皮病素食者，肥厚性扁平苔藓,和皮肌炎.在n=41（68％）的情况下，最常见的激光类型是脉冲染料激光（PDL）。八名（13％）患者接受了二氧化碳（CO2）激光治疗。最常见的治疗部位是面部。62％的患者反应良好，体征明显减少，而10％的患者对激光治疗无反应。自限性并发症包括紫癜和色素沉着过度。
■缺乏客观评估和结果措施。
■这是接受激光治疗炎症性皮肤病/结缔组织疾病的最大患者队列。根据这篇回顾性综述，我们得出的结论是,激光可以是治疗某些难以治疗的炎症和结缔组织疾病的有用辅助手段.
■评估激光治疗炎症性皮肤病和结缔组织疾病（CTD）的疗效。
■对2010年3月至2020年在三级激光诊所治疗的所有炎症性皮肤病/结缔组织疾病进行回顾性病例回顾。
■共纳入60例（48=女性），平均年龄为51岁（范围为21至74）。治疗以下疾病：硬皮病n=22（37％），面部肉芽肿n=10（17%），结节病n=8（13%），盘状红斑狼疮n=7（12％），和系统性红斑狼疮n=2（3％）。其他诊断包括脂肪坏死病，脓皮病素食者，肥厚性扁平苔藓,和皮肌炎.在n=41（68％）的情况下，最常见的激光类型是脉冲染料激光（PDL）。八名（13％）患者接受了二氧化碳（CO2）激光治疗。最常见的治疗部位是面部。62％的患者反应良好，体征明显减少，而10％的患者对激光治疗无反应。自限性并发症包括紫癜和色素沉着过度。
■缺乏客观评估和结果措施。
■这是接受激光治疗炎症性皮肤病/结缔组织疾病的最大患者队列。根据这篇回顾性综述，我们得出的结论是,激光可以是治疗某些难以治疗的炎症和结缔组织疾病的有用辅助手段.
