■评估谱域光学相干断层扫描(SD-OCT)对息肉状脉络膜血管病变(PCV)的诊断价值。
■从2010年到2021年进行了电子数据库的搜索,以回顾有关SD-OCT的相关文献,以识别PCV和其他引起严重或浆膜性视网膜色素上皮脱离(PED)的病变,特别是新生血管性年龄相关性黄斑变性(nvAMD)。采用QUADAS-2量表评价文献质量。我们进行了荟萃分析,包括异质性测试,分析和综合研究数据,元回归分析,亚组分析,费根的阴谋,敏感性分析和发表偏倚检验。
■本研究共纳入12项相关研究,涉及1348只眼,采用随机效应模型进行Meta分析。结果显示SD-OCT诊断PCV的合并敏感性为0.87(95%CI:0.84-0.89),合并特异性为0.83(95%CI:0.80-0.86),合并的阳性/阴性似然比为5.38(95%CI:3.28-8.80)和0.16(95%CI:0.10-0.25),分别。诊断比值比(DOR)为36.07(95%CI:15.98-81.40),sROC曲线下面积(AUC)为0.9429。当预测试概率设定为20%时,测试后的阳性和阴性概率分别为58%和4%,分别。Meta回归显示种族是异质性的主要来源(P<0.05)。Deeks漏斗图显示本研究无显著发表偏倚(P>0.05)。
■SD-OCT对PCV的诊断具有较高的敏感性和特异性,以及显著的临床适用性。由于彩色眼底照相(CFP)在临床上更容易使用,并且可以提高诊断效能,我们推荐SD-OCT联合CFP诊断PCV,特别是没有吲哚菁绿血管造影(ICGA)。
■https://inplasy.com/inplasy-2021-12-0048/,标识符:INPLASY2021120048。
UNASSIGNED: To evaluate the diagnostic value of spectral-domain optical coherence tomography (SD-OCT) for polypoidal choroidal vasculopathy (PCV).
UNASSIGNED: A search of electronic databases was conducted from 2010 to 2021 to
review the relevant literature on SD-OCT to identify PCV and other lesions causing serious or serosanguinous retinal pigment epithelial detachment (PED), specifically neovascular age-related macular degeneration (nvAMD). The QUADAS-2 scale was used to evaluate the quality of the literature. We performed a meta-analysis, including heterogeneity tests, analyze and synthesize the study data, meta-regression analysis, subgroup analysis, Fagan\'s plot, sensitivity analysis and publication bias tests.
UNASSIGNED: A total of 12 related studies involving 1,348 eyes were included in this study, and the random-effects model was used for meta-analysis. The results showed that the pooled sensitivity of SD-OCT in the diagnosis of PCV was 0.87 (95% CI: 0.84-0.89), the pooled specificity was 0.83 (95% CI: 0.80-0.86), and the pooled positive/negative likelihood ratios were 5.38 (95% CI: 3.28-8.80) and 0.16 (95% CI: 0.10-0.25), respectively. The diagnostic odds ratio (DOR) was 36.07 (95% CI: 15.98-81.40), and the area under the sROC curve (AUC) was 0.9429. When the pre-test probability was set at 20%, the post-test positive and negative probabilities were 58% and 4%, respectively. Meta-regression indicated that race was the primary source of heterogeneity (P <0.05). The Deeks\' funnel plot showed no significant publication bias in this study (P>0.05).
UNASSIGNED: SD-OCT has high sensitivity and specificity for the diagnosis of PCV, as well as significant clinical applicability. Since color fundus photography (CFP) is more clinically available and can improve the diagnostic efficacy, we recommend SD-OCT combined with CFP to diagnose PCV, especially without indocyanine green angiography (ICGA).
UNASSIGNED: https://inplasy.com/inplasy-2021-12-0048/, identifier: INPLASY2021120048.