The combination of non-specific deformable nanogels and plasmonic optical probes provides an innovative solution for specific sensing using a generalistic recognition layer. Soft polyacrylamide nanogels that lack specific selectivity but are characterized by responsive behavior, i.e., shrinking and swelling dependent on the surrounding environment, were grafted to a gold plasmonic D-shaped plastic optical fiber (POF) probe. The nanogel-POF cyclically challenged with water or alcoholic solutions optically reported the reversible solvent-to-phase transitions of the nanomaterial, embodying a primary optical switch. Additionally, the non-specific nanogel-POF interface exhibited more degrees of freedom through which specific sensing was enabled. The real-time monitoring of the refractive index variations due to the time-related volume-to-phase transition effects of the nanogels enabled us to determine the environment\'s characteristics and broadly classify solvents. Hence the nanogel-POF interface was a descriptor of mathematical functions for substance identification and classification processes. These results epitomize the concept of responsive non-specific nanomaterials to perform a multiparametric description of the environment, offering a specific set of features for the processing stage and particularly suitable for machine and deep learning. Thus, soft MathMaterial interfaces provide the ground to devise devices suitable for the next generation of smart intelligent sensing processes.

Plasmonic nanostructures serve in a range of analytical techniques that were developed for the analysis of chemical and biological species. Among others, they have been pursued for the investigation of odorant binding proteins (OBP) and their interaction with odorant molecules. These compounds are low molecular weight agents, which makes their direct detection with conventional surface plasmon resonance (SPR) challenging. Therefore, other plasmonic sensor modalities need to be implemented for the detection and interaction analysis of OBPs. This chapter provides a guide for carrying out such experiments based on two techniques that take advantage of conformation changes of OBPs occurring upon specific interaction with their affinity partners. First, there is discussed SPR monitoring of conformation changes of biomolecules that are not accompanied by a strong increase in the surface mass density but rather with its re-distribution perpendicular to the surface. Second, the implementation of surface plasmon-enhanced fluorescence energy transfer is presented for the sensitive monitoring of conformational changes of biomolecules tagged with a fluorophore at its defined part. Examples from our and other laboratories illustrate the performance of these concepts and their applicability for the detection of low molecular weight odorant molecules by the use of OBPs attached to the sensor surface is discussed.