Safranal(一种单萜醛)是藏红花的主要挥发性成分,是藏红花独特气味的原因。一些研究表明,藏药的药理活性包括抗氧化剂,抗炎,心脏保护,神经保护,肾保护,胃肠保护,等。这项研究旨在回顾安全和最新的先前知识的药理和医学作用。此外,收集了一些与safranal药理作用有关的专利。因此,电子数据库,包括WebofSciences,Scopus,并因药理作用和美国专利而出版,专利范围,从2010年到2022年6月,通过相关英文关键词对Google专利进行了全面搜索。根据我们的审查,大多数研究都与中枢神经系统的安全性作用有关,例如抗焦虑,镇痛药,抗惊厥药,抗缺血,抗震颤,记忆增强及其对神经退行性疾病如阿尔茨海默氏症的保护作用,帕金森病和亨廷顿病。安全的其他作用是平喘,抗高血压药,抗衰老,anticataract,等。此外,该药物对代谢综合征和糖尿病肾病具有保护作用。不同的机制,包括抗氧化剂,抗炎,肌肉放松,抗凋亡,以及对与氧化应激信号通路相关的基因和蛋白质表达的调节作用,炎症,凋亡,扩散,等。参与藏药药理作用。一些用于预防和/或治疗不同疾病如肝癌的专利,睡眠障碍,抑郁症,认知障碍,肥胖和PMS也包括在内.根据文件,尽管需要更多的临床研究来验证Safranal对人类的有益作用,但Safranal被认为是有前途的治疗剂。
Safranal (a monoterpene aldehyde) is the major volatile component of saffron which is responsible for the saffron unique odor. Several studies have shown the pharmacological activities of safranal including anti-oxidant, anti-inflammatory, cardioprotective, neuroprotective, nephroprotective, gastrointestinal protective, etc. This study was designed to
review the pharmacological and medical effects of safranal and up-to-date previous knowledge. Moreover, some patents related to the pharmacological effects of safranal were gathered. Therefore, electronic databases including Web of Sciences, Scopus, and Pubmed for pharmacological effects and US
patent, Patentscope, and Google
Patent for patents were comprehensively searched by related English keywords from 2010 to June 2022. According to our
review, most of the studies are related to the safranal effects on CNS such as antianxiety, analgesic, anticonvulsant, antiischemic, anti-tremor, memory enhancement and its protective effects on neurodegenerative disorders such as Alzheimer\'s, Parkinson and Huntington diseases. Other effects of safranal are antiasthmatic, antihypertensive, antiaging, anticataract, etc. Moreover, the protective effects of this agent on metabolic syndrome and diabetic nephropathy have been shown. Different mechanisms including anti-oxidant, anti-inflammatory, muscle relaxation, antiapoptotic, and regulatory effects on the genes and proteins expression related to signaling pathways of oxidative stress, inflammation, apoptosis, proliferation, etc. are involved in safranal pharmacological effects. Some patents for the prevention and/or treatment of different diseases such as liver cancer, sleep disorder, depression, cognitive disorder, obesity and PMS were also included. Based on the documents, safranal is considered a promising therapeutic agent although more clinical studies are needed to verify the beneficial effects of safranal in humans.