Abstract：
Green propolis is a resin produced from Baccharis dracunculifolia, which has as its main compounds flavonoids, derivatives of cinnamic acids, such as artepillin C and baccarin. This resin has antibacterial, antifungal, anti-inflammatory, antioxidant, and anticancer activities. This review aimed to analyze pharmaceutical patents containing green propolis in various formulations. The search was conducted in the National Institute of Industrial Property (INPI), the Patent Search of Spain and Latin America (Latipat-Espacenet), the World Intellectual Property Organization (WIPO), and Google Patents, with a combination of the keywords green propolis, green propolis extract, pharmacology, and pharmaceutical product. Primary research identified 60 patents, from which 22 were selected after applying the inclusion criteria. The selected patents referred to products with pharmacological activities, from cancer treatment to food supplements and included innovations for improved controlled release of the green propolis compounds. Most of the documents concerned the preparation and/or formulation of the green propolis extract, followed by innovative extraction methods, treatment and systemic use, and finally by topical use and quality control techniques and procedures. Thus, the reviewed patents of green propolis provided valuable insights into the pharmaceutical applications of green propolis, showing its potential in diverse formulations and treatments.
摘要：
绿色蜂胶是一种由麦草芽孢杆菌生产的树脂，它的主要化合物是类黄酮，肉桂酸衍生物，例如ArtepillinC和百家乐。这种树脂有抗菌作用,抗真菌药,抗炎,抗氧化剂，和抗癌活动。这篇综述旨在分析各种配方中含有绿色蜂胶的药物专利。搜索是在国家工业产权研究所（INPI）进行的，西班牙和拉丁美洲专利检索（Latipat-Espacenet），世界知识产权组织(WIPO),和谷歌专利，结合了绿色蜂胶的关键字，绿色蜂胶提取物，药理学,和医药产品。初步研究确定了60项专利，在应用纳入标准后从中选出22人.选定的专利涉及具有药理活性的产品，从癌症治疗到食品补充剂，包括改善绿色蜂胶化合物控释的创新。大多数文件涉及绿色蜂胶提取物的制备和/或配方，其次是创新的提取方法，治疗和全身使用，最后通过局部使用和质量控制技术和程序。因此，审查的绿色蜂胶专利为绿色蜂胶的制药应用提供了宝贵的见解，显示其在不同的配方和治疗的潜力。
