目的:本研究评估了临床早期(I,II)恶性卵巢生殖细胞肿瘤(MOGCT)。
方法:回顾性多中心研究。
方法:中国四所大学教学医院。
方法:共268例临床上明显的早期患者(I,II)MOGCT。
方法:数据来自病历。此外,采用倾向得分匹配(PSM)算法。
方法:预后结果为无病生存期(DFS)和总生存期(OS)。生育结果是妊娠和活产率。
结果:总共187例(69.8%)患者接受了网膜切除术。Kaplan-Meier分析显示,PSM前后大网膜切除组和非大网膜切除组的DFS和OS差异无统计学意义(p>0.05)。此外,按年龄(<18岁和≥18岁)分层的亚组分析显示结果相似.国际妇产科联合会(FIGO)分期是与DFS(风险比[HR]14.71,95%置信区间[CI]4.47-48.38,p<0.001)和OS(HR37.36,95%CI3.87-361.16,p=0.002)相关的唯一危险因素。总人口的妊娠率和活产率分别为80.3%和66.7%,分别。PSM前后两组间差异无统计学意义。
结论:在临床上明显的早期阶段的患者中,眼球切除术并没有提高生存率或影响生育能力(I,II)MOGCT,不管年龄。临床FIGO分期是复发和死亡的独立危险因素。
This
study assessed the effect of
omentectomy on the prognosis and fertility in patients with clinically early-stage (I, II) malignant ovarian germ cell tumours (MOGCT).
A retrospective multicentre
study.
Four university teaching hospitals in China.
A total of 268 patients with clinically apparent early-stage (I, II) MOGCT.
Data were obtained from the medical records. Additionally, the propensity score matching (PSM) algorithm was adopted.
Prognostic outcomes were disease-free survival (DFS) and overall survival (OS). Fertility outcomes were pregnancy and live birth rates.
A total of 187 (69.8%) patients underwent
omentectomy. Kaplan-Meier analysis showed no significant differences in DFS and OS between the
omentectomy and non-
omentectomy groups before and after PSM (p > 0.05). Additionally, subgroup analysis stratified by age (<18 and ≥18 years) showed similar results. International Federation of Gynecology and Obstetrics (FIGO) stage was the only risk factor associated with DFS (hazard ratio [HR] 14.71, 95% confidence interval [CI] 4.47-48.38, p < 0.001) and OS (HR 37.36, 95% CI 3.87-361.16, p = 0.002). Pregnancy and live birth rates in the total population were 80.3% and 66.7%, respectively. There were no significant differences between the two groups before and after PSM.
Omentectomy did not improve survival or affect fertility in patients with clinically apparent early-stage (I, II) MOGCT, regardless of the age. The clinical FIGO stage was an independent risk factor for recurrence and death.