neurological impairment

  • 文章类型: Case Reports
    电气损伤是发展中国家的普遍现象,由于日常电气维修过程中采取的安全措施不足。工作场所伤害占其中的20%。在一些严重的情况下,电损伤导致烧伤,间接骨折脱位,言语障碍,等。由于电损伤导致继发性并发症的跌倒非常普遍,即使不是很严重,他们确实需要立即治疗和充分康复。一名53岁的男性在电击后肩部受伤。患者还经历了刺激和言语障碍。检查显示肩关节范围减少,肩关节肌肉紧绷。物理治疗干预包括为患者及其家人提供咨询,节能方法,便于日常活动,康复方案,和改良的音乐疗法。用于评估进展的结果指标包括肩痛和残疾指数(SPADI),运动恐惧症的坦帕量表(TSK),抑郁、焦虑和压力量表。通过早期力量训练,辅助治疗的康复可有效改善患者的心理健康和身体健康状况。
    Electrical injuries are common phenomena in developing countries, due to inadequate safety measures followed during day-to-day electrical repairs. Workplace injuries account for 20% of these. In some severe cases, electrical injuries lead to burns, indirect fracture dislocations, speech impairments, etc. Falls due to electrical injuries leading to secondary complications are very common and, even though not very severe, they do require immediate treatment and adequate rehabilitation. A 53-year-old male suffered a shoulder injury following an electrical shock. The patient also experienced irritation and speech disturbances. Examination revealed a reduced range of shoulder joints and tightness of muscles of the shoulder complex. Physiotherapy intervention included counseling for the patient and his family members, energy conservation methods for ease in daily activities, a rehabilitation protocol, and modified music therapy. Outcome measures used to assess the progression constituted the Shoulder Pain and Disability Index (SPADI), the Tampa Scale for Kinesiophobia (TSK), and the Depression and Anxiety and Stress Scale. Rehabilitation with adjunct therapy is effective in the overall improvement of the patient\'s condition concerning their mental health as well as physical health by early strength training.
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  • 文章类型: Journal Article
    背景:视力障碍是神经系统损害的常见后果,并且会影响一个人承担日常任务的能力,影响他们的信心和心理健康。以前在英国的定性研究表明,在中风后患者获得视力护理的地方存在不平等,但是对其他神经损伤后获得视力护理的经验知之甚少,缺乏国家指导方针,阻碍了标准化护理计划。这项定性研究的目的是探索神经功能缺损后对视力护理的看法,并确定可能的不平等和支持机制,在那里可以获得视力保健。
    方法:获得了大学伦理批准,对因神经功能缺损而导致视力障碍的成年人进行了深入访谈,以探讨他们的视力护理经验。数据在2021年4月至11月之间收集,并使用迭代进行分析,专题分析(TA),受社会建构主义意识形态的影响。
    结果:招募了17名参与者。关于参与者对视力护理的感知,概念化了三个总体主题:理解视力障碍;视力护理的责任;以及护理质量感知的影响因素。
    结论:参与者注意到不平等,大多数人报告缺乏作为神经系统康复的一部分提供的合适的视力护理。因此,参与者承担了在网上寻求自己支持的任务,并在此过程中遇到了不准确和令人担忧的信息。参与者注意到他们身份的变化,以及他们家庭照顾者的身份,当他们适应视力丧失的时候。这项研究的发现强调了临床医生需要考虑神经功能缺损后视力丧失的长期影响,并确保为患者提供足够的支持和信息,和适当的转诊途径,减轻病人的负担。
    BACKGROUND: Visual impairment is a common consequence of neurological impairments, and can impact a person\'s ability to undertake everyday tasks, affecting their confidence and mental health. Previous qualitative research in the UK has shown inequalities to exist where patients are accessing vision care after stroke, but little is known around the experiences of accessing vision care following other neurological impairments, and a lack of national guidelines prevent standardised care planning. The aim of this qualitative study is to explore the perceptions of vision care after neurological impairment, and to identify possible inequalities and support mechanisms, where it has been possible to access vision care.
    METHODS: University ethical approval was obtained, and adults with a visual impairment as a result of a neurological impairment were offered an in-depth interview to explore their vision care experiences. Data were collected between April and November 2021 and analysed using iterative, thematic analysis (TA), informed by a social constructionist ideology.
    RESULTS: Seventeen participants were recruited. Three overarching themes were conceptualised in relation to the participants\' perception of vision care: Making sense of the visual impairment; The responsibility of vision care; and Influential factors in care quality perception.
    CONCLUSIONS: Inequalities were noted by participants, with most reporting a lack of suitable vision care offered as part of their neurological rehabilitation. Participants were thus burdened with the task of seeking their own support online, and encountered inaccurate and worrying information in the process. Participants noted changes in their identity, and the identity of their family carers, as they adjusted to their vision loss. The findings from this research highlight a need for clinicians to consider the long-term impact of vision loss after neurological impairment, and ensure patients are provided with adequate support and information, and appropriate referral pathways, alleviating this patient burden.
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  • 文章类型: Journal Article
    背景:神经损伤(NI)涉及中枢神经系统的疾病。NI的具体病因各不相同,但包括遗传,先天性异常或脑损伤。在患有严重NI的儿童中,进食障碍会导致营养不良,有些孩子需要喂食管。虽然管饲改善了整体营养状况,它也与身体脂肪过多有关。市售肠内配方,能量低,水解和营养充足的蛋白质和微量营养素可用于减轻胃肠道症状和肥胖。
    方法:这是一项针对2022年1月至2023年7月期间在NI诊所就诊的儿童的回顾性多中心研究。数据收集之前和接受低能量,人口统计数据上的部分水解肠内配方(0.6千卡/毫升)(年龄,性别,种族和NI诊断),人体测量(体重,高度,年龄体重Z评分,身高年龄Z分,体重指数[BMI]Z评分)和饲料方案(饲料量,总液体和配方/补充剂的类型)。
    结果:营养师收集了28名儿童的数据,中位年龄为7岁(四分位距[IQR]3,8).最常记录的NI是脑瘫,28名儿童中有13名(48%)。在公式转换之前,最常见的胃肠道症状是便秘,28个孩子中的13个。在切换到低能耗的1个月内,水解配方,13名儿童中有10名(77%)报告便秘有所改善。在公式转换之前,所有28名儿童都经历了过多的体重增加.配方切换到低能量后,水解配方,营养师报告说,28名儿童中有20名(76%)的体重在1个月后稳定或减少。公式转换后,年龄体重Z评分或BMIZ评分无统计学差异(p值分别为0.1和0.09)。配方转换后,纤维摄入量从3.3g/天显着增加到8.1g/天(p值<0.01)。改用低能量喂养后简化喂养方案的儿童数量,部分水解的配方是28个中的24个(91%)。
    结论:有胃肠道症状的NI患儿可能会从低能量治疗中获益,水解肠内配方,以最大限度地提高饲料耐受性和促进健康的体重增加。此外,换成低能耗的,水解配方可以通过消除对额外电解质的需求来简化饲料方案,多种维生素和液体丸剂。医疗保健专业人员应该了解低能耗的有效性和可用性,水解配方。
    BACKGROUND: Neurological impairment (NI) relates to disorders of the central nervous system. The specific aetiology of NI varies but includes genetic, congenital abnormalities or brain injury. In children with severe NI, feeding impairments can lead to undernutrition, and some children require a feeding tube. Although tube feeding improves overall nutritional status, it has also been associated with excess body fat. Commercially available enteral formulas that are low in energy, hydrolysed and nutritionally adequate for protein and micronutrients are available to mitigate gastrointestinal symptoms and obesity.
    METHODS: This is a retrospective multicentre study of children who attended NI clinics between January 2022 and July 2023. Data were collected before and 1 month after receiving a low-energy, partially hydrolysed enteral formula (0.6 kcal/mL) on demographic data (age, sex, ethnicity and NI diagnosis), anthropometric measurements (weight, height, weight-for-age Z-score, height-for-age Z-score, body mass index [BMI] Z-score) and feed regimen (feed volume, total fluids and type of formula/supplements).
    RESULTS: Dietitians collected data on 28 children, the median age was 7 years (interquartile range [IQR] 3, 8). The most frequently recorded NI was cerebral palsy, in 13 of 28 children (48%). Before the formula switch, the most frequently reported gastrointestinal symptom was constipation, in 13 of 28 children. Within 1 month of switching to a low-energy, hydrolysed formula, 10 of the 13 (77%) children reported an improvement in constipation. Before the formula switch, all 28 children were experiencing excessive weight gain. After the formula was switched to low-energy, hydrolysed formula, dietitians reported that 20 of the 28 (76%) children\'s weight either stabilised or reduced after 1 month. There was no statistically significant difference in weight-for-age Z-score or BMI Z-scores postswitch of formula (p-value 0.1 and 0.09, respectively). Fibre intake increased significantly from 3.3 to 8.1 g/day (p-value < 0.01) after formula switch. The number of children whose feed regimens were simplified after switching to a low-energy, partially hydrolysed formula was 24 of 28 (91%).
    CONCLUSIONS: Children with an NI who have gastrointestinal symptoms may benefit from a low-energy, hydrolysed enteral formula to maximise feed tolerance and promote healthy weight gain. In addition, changing to a low-energy, hydrolysed formula may simplify feed regimens by eliminating the need for additional electrolytes, multivitamins and fluid boluses. Healthcare professionals should be knowledgeable about the effectiveness and availability of a low-energy, hydrolysed formula.
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  • 文章类型: Clinical Trial Protocol
    患有神经功能缺损的儿童可能有吞咽困难和/或胃食管反流病(GERD),容易导致影响气道的并发症,增加吸入性急性和慢性肺病的风险,或者其次是营养不良,进一步的神经发育障碍,与护理人员的紧张互动和慢性疼痛。仅应用多学科临床喂养评估和经验试验来为与吞咽困难或GERD相关的喂养困难的管理提供支持。但是在任何年龄都没有标准化的喂养或行为措施来评估误吸风险,并支持进行视频透视吞咽研究(VFSS)或光纤内窥镜吞咽检查(FEES)的指征,特别是新生儿和有神经损伤的婴儿。肺超声(LUS)已被提出作为一种非侵入性,用于诊断婴儿肺部疾病的无辐射工具,具有较高的敏感性和特异性。
    RCT将在0至6岁的婴儿中进行,或者有风险,脑瘫,或其他神经发育疾病,通过婴儿定量量表评估确定异常的肌张力或运动发育迟缓,或者根据临床症状怀疑GERD或吞咽困难。婴儿将被分为2组:1)LUS监测管理(LUS-m);2)标准护理管理(SC-m)和基线评估后(T0),两组均接受为期6个月的实验性随访.前三个月,婴儿将每月至少接受1次评估,在医院,总共进行了3次LUS监测的膳食评估。主要和次要终点测量将在3个月和6个月收集。
    本文描述了由RCT组成的研究方案,其主要目的有两个:(1)评估使用LUS监测吞咽困难的沉默和明显吸入的益处及其对肺部疾病和生长的影响;(2)调查LUS管理对血液样本和骨代谢的影响,疼痛和与护理人员的互动。
    试验注册日期02/05/2020;ClinicalTrials.gov标识符:NCT04253951。
    Children with neurological impairment may have dysphagia and/or gastro-esophageal reflux disease (GERD), which predispose to complications affecting the airways, increasing risk for aspiration-induced acute and chronic lung disease, or secondarily malnutrition, further neurodevelopmental disturbances, stressful interactions with their caregivers and chronic pain. Only multidisciplinary clinical feeding evaluation and empirical trials are applied to provide support to the management of feeding difficulties related to dysphagia or GERD, but no standardized feeding or behavioral measure exists at any age to assess aspiration risk and support the indication to perform a videofluoroscopic swallowing study (VFSS) or a fibre-optic endoscopic examination of swallowing (FEES), in particular in newborns and infants with neurological impairments. Lung ultrasound (LUS) has been proposed as a non-invasive, radiation-free tool for the diagnosis of pulmonary conditions in infants, with high sensitivity and specificity.
    A RCT will be conducted in infants aged between 0 and 6 years having, or being at risk for, cerebral palsy, or other neurodevelopmental disease that determines abnormal muscular tone or motor developmental delay assessed by a quantitative scale for infants or if there is the suspicion of GERD or dysphagia based on clinical symptoms. Infants will be allocated in one of 2 groups: 1) LUS-monitored management (LUS-m); 2) Standard care management (SC-m) and after baseline assessment (T0), both groups will undergo an experimental 6-months follow-up. In the first 3 months, infants will be evaluated a minimum of 1 time per month, in-hospital, for a total of 3 LUS-monitored meal evaluations. Primary and secondary endpoint measures will be collected at 3 and 6 months.
    This paper describes the study protocol consisting of a RCT with two main objectives: (1) to evaluate the benefits of the use of LUS for monitoring silent and apparent aspiration in the management of dysphagia and its impact on pulmonary illness and growth and (2) to investigate the impact of the LUS management on blood sample and bone metabolism, pain and interaction with caregivers.
    Trial registration date 02/05/2020; ClinicalTrials.gov Identifier: NCT04253951 .
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  • 文章类型: Journal Article
    In the first days after birth, a major focus of research is to identify infants with hypoxic-ischemic encephalopathy at higher risk of death or severe neurological impairment, despite therapeutic hypothermia (TH). This is especially crucial to consider redirection of care, according to neonatal outcome severity. We aimed to seek associations between some neonatal routine parameters, usually recorded in Neonatal Intensive Care Units, and the development of severe outcomes. All consecutive patients prospectively recruited for TH for perinatal asphyxia, born between February 2009 and July 2016, were eligible for this study. Severe outcome was defined as death or major neurological sequelae at one year of age. Among all eligible neonates, the final analysis included 83 patients. Severe outcome was significantly associated with pH and base excess measured in the first hour of life, mode of delivery, Apgar score, Sarnat and Sarnat score, electroencephalogram-confirmed neonatal epileptic seizures, and antiepileptic therapy. Studying univariate analysis by raw relative risk (RR) and 95% confidence intervals (CI), severe outcome was significantly associated with pH (p = 0.011), Apgar score (p = 0.003), Sarnat score (p < 0.001), and Caesarian section (p = 0.015). Conclusions. In addition to clinical examination, we suggest a clinical-electroencephalographic protocol useful to identify neonates at high neurological risk, available before rewarming from TH.
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  • 文章类型: Observational Study
    这个未来,观察性队列研究调查了Covid-19后遗症和持续性症状的多学科康复的效果及其对患者功能和生活质量的影响。
    从58名接受神经康复的患者中,43人符合资格并参与了本研究。复健前后8周,患者接受了体检,神经心理学和呼吸评估以及功能独立性的评估,疲劳和生活质量的影响。
    43人中有40人(52±11.4岁,24名男性)完成了康复计划。疲劳(87.5%),呼吸困难和/或呼吸急促(62.5%),和认知障碍(37.5%)的报告均为既往住院和家庭住院患者.仅在住院患者中出现神经系统后遗症(35.5%)。经过8周的康复,患者报告运动功能独立性显著改善,上肢和下肢功能,疲劳对日常活动的影响,呼吸肌力量,认知表现,和生活质量。
    Covid-19后出现神经异质性的患者,物理,和呼吸损伤需要多学科康复方法,以减少残疾,提高功能和生活质量。对临床概况和康复反应的全面评估可能有助于识别康复候选人,并有助于设计有效的康复干预措施。对康复的影响Covid-19后患者表现出多种,异质性神经学,在先前住院和家庭住院患者中观察到的身体和呼吸损伤。八周的多学科康复可以显着减少残疾并改善功能和生活质量。全面评估其临床概况和对康复的反应可能有助于识别康复候选人,并有助于设计更有效的康复干预措施。
    This prospective, observational cohort study investigated the effects of multidisciplinary rehabilitation of post Covid-19 sequelae and persistent symptoms and their impact on patients\' functioning and quality of life.
    From 58 patients referred for neurorehabilitation, 43 were eligible for and participated in the present study. Before and after 8 weeks of rehabilitation, patients underwent physical, neuropsychological and respiratory evaluations and assessment of functional independence, impact of fatigue and quality of life.
    Forty of 43 individuals (52 ± 11.4 years, 24 male) completed the rehabilitation program. Fatigue (87.5%), dyspnea and/or shortness of breath (62.5%), and cognitive impairment (37.5%) were reported by both previously hospitalized and home-confined patients. Neurological sequelae (35.5%) were present only in hospitalized patients. After 8 weeks of rehabilitation, patients reported significant improvements in motor functional independence, upper and lower limb functionality, impact of fatigue on daily activities, respiratory muscle strength, cognitive performance, and quality of life.
    Post Covid-19 patients present with heterogeneous neurological, physical, and respiratory impairments requiring a multidisciplinary rehabilitation approach to reduce disability and improve functionality and quality of life. A comprehensive assessment of clinical profiles and responses to rehabilitation may facilitate the identification of rehabilitation candidates and help to design effective rehabilitation interventions.Implication for rehabilitationPost Covid-19 patients present multiple, heterogeneous neurological, physical and respiratory impairments that are observed in both previously hospitalized and home-confined patients.Eight weeks of multidisciplinary rehabilitation may significantly reduce disability and improve functionality and quality of life.A comprehensive assessment of their clinical profile and response to rehabilitation may facilitate the identification of rehabilitation candidates and help to design more effective rehabilitation interventions.
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  • 文章类型: Journal Article
    Gastrostomy placement is crucial in neurologically impaired (NI) children to ensure an adequate food intake and a safe route for drugs administration and to reduce the risk of primary aspiration. NI patents are more prone to gastroesophageal reflux. The association with fundoplication is deemed to reduce reflux-related respiratory complications. However, long-term benefits of this approach are not clear. We therefore aimed to compare long-term reflux-related respiratory complications of gastrostomy only (GO) to gastrostomy with fundoplication (GF). We retrospectively reviewed 145 consecutive NI children managed from 2008 to 2018. As long-term outcomes, we analyzed number and length of hospital admissions (Reflux-Related-Hospitalization, RRH) and emergency department accesses (Reflux-Related-Accesses, RRA) due to respiratory problems. Results were analyzed with appropriate statistical method. Median age at referral and at gastrostomy placement were 2.2 and 3.4 years (SD 5.6), respectively. Median follow-up was four years (range 1-12). Anti-reflux procedures were performed in 26/145 patients (18%); tracheotomy in 23/145 (16%). RRH following surgery showed lower number of admissions/year (0.32 vs. 1 for GO vs. GF, p < 0.005) and days hospitalization/year (3 vs. 13, p = 0.08) in GO compared to GF; RRA was similar (0.60 vs. 0.65, p = 0.43). Gastrostomy placement alone appeared not to be inferior to gastrostomy plus fundoplication with respect to long-term respiratory-related outcomes for NI children in our center.
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  • 文章类型: Journal Article
    Background: Optimal surgical management of spinal injuries as part of life-threatening multiple traumas remains challenging. We provide insights into the surgical management of spinal injuries in polytrauma patients. Methods: All patients from our polytrauma care network who both met at least one positive Vittel criteria and an injury severity score (ISS) >15 at admission and who underwent surgery for a spinal injury were included retrospectively. Demographic data, clinical data demonstrating the severity of the trauma and imaging defining the spinal and extraspinal number and types of injuries were collected.Results: Between January 2012 and December 2016, 302 (22.2%) patients suffered from spinal injury (143 total injuries) and 83 (6.1%) met the inclusion criteria. Mean ISS was 36.2 (16-75). Only 48 (33.6%) injuries led to neurological impairment involving the thoracic (n = 23, 16.1%) and lower cervical (n = 15, 10.5%) spine. The most frequent association of injuries involved the thoracic spine (n = 42). 106 spinal surgeries were performed. The 3-month mortality rate was 2.4%.Conclusions: We present data collected on admission and in the early postoperative period referring to injury severity, the priority of injuries, and development of multi-organ failure. We revealed trends to guide the surgical support of spinal lesions in polytrauma patients.
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  • 文章类型: Journal Article
    营养不良在神经系统受损(NI)儿童中很常见。通过胃造口管的肠内喂养越来越多地用于提供足够的营养。我们的目的是评估NI患儿使用标准聚合物配方进行独家胃造瘘管喂养的结果,严重的口运动功能障碍,营养不良,并研究潜在NI相关疾病的作用。从2013年1月至2017年11月进行了为期五年的回顾性研究。主要目的是评估营养不良的NI儿童使用标准聚合物配方进行独家胃造瘘管喂养的营养结果。次要目的是调查胃造口术并发症以及潜在的NI相关疾病对营养结局的影响。我们连续招募了110名患有NI的儿童。在这些病人中,34.5%(N=38)被归类为营养不良,并开始使用标准(1.0kcal/mL)聚合配方(Nutrini,Nutricia)经皮内镜胃造瘘术(PEG)放置后。73%的患者(N=28)患有脑瘫(CP);其他诊断包括代谢(13%,N=5)和遗传(13%,N=5)疾病。在12个月的随访中,所有患者的Tricep皮褶厚度均有明显改善,而体重和体重指数显着增加主要在CP儿童中。无严重并发症发生。我们发现通过胃造瘘管的标准聚合物配方代表了NI和营养不良儿童的安全有效的营养干预。
    Malnutrition is frequent in neurologically impaired (NI) children. Enteral feeding via gastrostomy tube is increasingly being used to provide adequate nutrition. Our aim was to assess the outcomes of exclusive gastrostomy tube feeding with standard polymeric formula in children with NI, severe oro-motor dysfunction, and malnutrition, and to investigate the role of the underlying NI-associated disease. A five-year retrospective study from January 2013 to November 2017 was conducted. The primary aim was to assess the nutritional outcomes of exclusive gastrostomy tube feeding with standard polymeric formula in malnourished NI children. The secondary aim was to investigate gastrostomy complications and the impact of the underlying NI-associated disease on the nutritional outcomes. We enrolled 110 consecutive children with NI. Of these patients, 34.5% (N = 38) were categorized as malnourished and started exclusive enteral feeding with a standard (1.0 kcal/mL) polymeric formula (Nutrini, Nutricia) after percutaneous endoscopic gastrostomy (PEG) placement. Seventy-three percent of patients (N = 28) had cerebral palsy (CP); other diagnoses included metabolic (13%, N = 5) and genetic (13%, N = 5) diseases. Tricep skinfold thickness had significantly improved in all patients at 12-months follow-up, while body weight and body mass index showed significant increases mainly in children with CP. No serious complications occurred. We found that standard polymeric formula via gastrostomy tube represents a safe and efficient nutritional intervention in children with NI and malnutrition.
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  • 文章类型: Journal Article
    Increasing clinical use of Intrathecal baclofen (ITB) in Australian tertiary paediatric hospitals, along with the need for standardised assessment and reporting of adverse events, saw the formation of the Australian Paediatric ITB Research Group (APIRG). APIRG developed a National ITB Audit tool designed to capture clinical outcomes and adverse events data for all Australian children and adolescents receiving ITB therapy.
    The Australian ITB Audit is a 10 year, longitudinal, prospective, clinical audit collecting all adverse events and assessment data across body functions and structure, participation and activity level domains of the ICF. Data will be collected at baseline, 6 and 12 months with ongoing capture of all adverse event data. This is the first Australian study that aims to capture clinical and adverse event data from a complete population of children with neurological impairment receiving a specific intervention between 2011 and 2021. This multi-centre study will inform ITB clinical practice in children and adolescents, direct patient selection, record and aid decision making regarding adverse events and investigate the impact of ITB therapy on family and patient quality of life.
    This project was approved by the individual Human Research Ethics committees at the six Australian tertiary hospitals involved in the study. Results will be published in various peer reviewed journals and presented at national and international conferences.
    ACTRN 12610000323022; Pre-results.
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