目的：使用可注射填充产品进行口周恢复的非手术程序已经出现并迅速发展，成为最常用的美学治疗方法之一。我们报告了一个案例系列，描述了使用作者开发的技术使用两种具有出色特性和配方的基于透明质酸的真皮填充剂（HA填充剂）的给药。
方法：我们描述了一系列9名女性受试者，他们由一名医生在她的私人诊所进行口周恢复。使用专门开发的Clodia技术将HA填充剂(Alaxin®FL或Alaxin®LV)注射到嘴唇中。患者被给予治疗后建议以获得最佳结果。使用全球美学改善量表（GAIS）对患者和研究者感知的结果进行评估，并收集不良事件（AE）。
结果：所有受试者描述注射方法无痛且耐受性良好，如即时后处理照片所示。患者和研究者的平均GAIS评分均为4.8/5,表明治疗后12个月有显著改善。随访期间未报告AE。HA填充剂在所有受试者中均显示出高度的真皮整合，研究者报告了优异的处理和注射性能。
结论：使用开发的注射技术给予HA填充剂的口服周期恢复在所有受试者中产生了非常令人满意的结果，并且与不良事件无关。
OBJECTIVE: Non-surgical procedures using injectable filler products for perioral rejuvenation have emerged and evolved rapidly to become one of the most frequently performed aesthetic treatments. We report a
case series describing the administration of two hyaluronic acid-based dermal fillers (HA filler) with excellent characteristics and formulation using a technique developed by the author.
METHODS: We describe a series of nine female subjects who underwent perioral rejuvenation performed by a single physician in her private clinic. The HA filler (Alaxin® FL or Alaxin® LV) was injected into the lips using the specially developed Clodia technique. Patients were given post-treatment advice for optimal results. Patient- and investigator-perceived outcomes were rated using the Global Aesthetic Improvement Scale (GAIS) and adverse events (AEs) were collected.
RESULTS: All subjects described the injection method as painless and well tolerated, as shown by the immediate post-treatment photographs. Mean GAIS scores for both the patients and the investigator were 4.8/5, indicating significant improvement 12 months after the treatment. No AEs were reported during follow-up. The HA filler showed a high degree of dermal integration in all subjects, and the investigator reported excellent handling and injection properties.
CONCLUSIONS: Perioral rejuvenation with an HA filler administered using the developed injection technique gave highly satisfactory results in all subjects and was not associated with AEs.
