我们研究了牛奶过敏(CMA)与幼年特发性关节炎(JIA)之间的关系。本病例对照研究的材料是从2000年至2010年在芬兰出生并被诊断为JIA(n=1,298)和年龄-的所有儿童的国家登记册中收集的。sex-,和地点匹配的对照(n=5,179)。我们确定了235名CMA儿童;其中66名儿童也患有JIA。进行了条件逻辑回归分析,以评估CMA和JIA之间的关联,并测试抗生素暴露是否会成为这种关联的协变量。在男孩(但不是女孩),CMA的诊断和婴儿期使用低变应原性配方与JIA的后期发展相关(比值比=2.4,95%置信区间:1.6,3.6).这种关联在3岁之前被诊断为JIA或被诊断为主要胃肠道症状的CMA的男孩中最为明显。在JIA的后期发展中,CMA与抗生素暴露之间没有统计学上显着的累加相互作用。这些关联可能反映了有JIA风险的男孩肠道免疫和完整性的成熟受损。与JIA发病机制相关的诱发因素似乎显示出与性别相关的差异。
We examined the association between cow\'s milk allergy (CMA) and juvenile idiopathic arthritis (JIA). The material for this
case-control study was collected from national registers of all children born in Finland between 2000 and 2010 and diagnosed with JIA (n = 1,298) and age-, sex-, and place-matched controls (n = 5,179). We identified 235 children with CMA; 66 of these children also had JIA. A conditional logistic regression analysis was performed to evaluate the association between CMA and JIA and to test whether exposure to antibiotics would be a covariate for this association. In boys (but not in girls), a diagnosis of CMA and the use of hypoallergenic formula in infancy were associated with the later development of JIA (odds ratio = 2.4, 95% confidence interval: 1.6, 3.6). The association was most evident in boys who were diagnosed with JIA before age 3 years or diagnosed with CMA with predominantly gastrointestinal symptoms. There was no statistically significant additive interaction between CMA and antibiotic exposure in the later development of JIA. These associations may reflect impaired maturation of intestinal immunity and integrity in boys with a risk of JIA. Predisposing factors related to JIA pathogenesis seem to display a sex-linked disparity.