关键词: Chronic kidney disease Hyperkalemia Infant Milk allergy Sodium polystyrene sulfonate

来  源:   DOI:10.1007/s13730-022-00704-3

Abstract:
The 8806H formula is the only renal formula available for pediatric patients with chronic kidney disease in Japan. A 1-month-old female infant could not be administered 8806H because of milk allergy. Administration of low-potassium anti-allergic formula treated with sodium polystyrene sulfonate maintained adequate serum potassium levels, and introduction of peritoneal dialysis could be delayed. The patient had severe renal dysfunction secondary to bilateral hypoplastic and multi-cystic kidneys. Although she received the 8806H formula, this product was switched to hydrolyzed casein formula because she developed allergy to 8806H at 28 days of age, which led to hyperkalemia. We initiated treatment with sodium polystyrene sulfonate at 40 days of age to lower the potassium concentration in milk, which prevented hyperkalemia and maintained the patient\'s nutritional status to ensure appropriate increase in body weight. We monitored electrolyte levels in milk and confirmed reduction in potassium levels before feeding. Although such condition is rare and there are few reports of potassium reduction in anti-allergic formulas, this strategy may be useful for pediatric patients with renal insufficiency who cannot be treated with renal formulas because of milk allergy.
摘要:
8806H配方是日本唯一可用于患有慢性肾脏疾病的儿科患者的肾脏配方。1个月大的女婴由于牛奶过敏而不能给药8806H。给予聚苯乙烯磺酸钠治疗的低钾抗过敏配方维持了足够的血清钾水平,腹膜透析的引入可能会延迟。患者患有严重的肾功能不全,继发于双侧增生性和多囊性肾脏。尽管她收到了8806H配方,该产品被转换为水解酪蛋白配方,因为她在28日龄时对8806H过敏,导致了高钾血症.我们在40日龄时开始用聚苯乙烯磺酸钠治疗,以降低牛奶中的钾浓度,预防高钾血症并维持患者的营养状况,以确保适当增加体重。我们监测了牛奶中的电解质水平,并在喂食前确认了钾水平的降低。尽管这种情况很少见,并且很少有抗过敏配方中钾减少的报道,对于因牛奶过敏而无法接受肾脏配方治疗的肾功能不全患儿,此策略可能有用.
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