目的:探讨转化生长因子β基质金属蛋白9(MMP-9),金属蛋白酶组织抑制剂1(TIMP-1),白细胞介素1(IL-1),IL-4,IL-6,IL-17和肿瘤坏死因子α(TNF-α)在难治性慢性鼻-鼻窦炎中的作用。
方法:2018年8月至2020年2月,共有150名参与者回顾性纳入本研究。纳入的患者平均分为难治性组(难治性慢性鼻-鼻窦炎患者),慢性组(慢性鼻窦炎患者),对照组(正常人)。记录TGF-β1、MMP-9、TIMP-1、IL-1、IL-4、IL-6、IL-17和TNF-α水平。采用非条件多因素二元logistic回归分析难治性慢性鼻-鼻窦炎的影响因素。
结果:达沃斯评分,T&T嗅觉仪阈值测试,难治性组Lund-MackayCT评分明显高于慢性组(P<0.05)。难治性组TGF-β1、MMP-9、TIMP-1、IL-1、IL-4、IL-6、IL-17、TNF-α水平明显高于慢性组及对照组(均P<0.05)。同样,慢性组上述指标水平明显高于对照组(P<0.05)。达沃斯的得分,T&T嗅觉仪阈值测试评分,Lund-MackayCT评分,TGF-β1,MMP-9,TIMP-1,IL-1,IL-4,IL-6,IL-17和TNF-α水平与难治性慢性鼻-鼻窦炎呈正相关。此外,非条件多因素二元logistic回归分析显示,难治性慢性鼻-鼻窦炎的影响因素包括TGF-β1、MMP-9、TIMP-1、IL-1、IL-4、IL-6、IL-17和TNF-α。
结论:本研究结果为TGF-β1、MMP-9、TIMP-1、IL-4、IL-6、IL-17和TNF-α是难治性慢性鼻窦炎的影响因素提供了证据。
OBJECTIVE: To investigate the potential correlation of transforming growth factor-β (TGF-β), matrix metalloprotein 9 (MMP-9), tissue inhibitor of metalloproteinases 1 (TIMP-1), Interleukin 1 (IL-1), IL-4, IL-6, IL-17, and tumor necrosis factor alpha (TNF-α) in refractory chronic rhinosinusitis.
METHODS: A total of 150 participants were retrospectively included in this
study from August 2018 to February 2020. The people enrolled were equally allocated into refractory group (patients with refractory chronic rhinosinusitis), chronic group (patients with chronic rhinosinusitis), and control group (normal people). The level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α were recorded. The unconditional multivariate binary logistic regression was used to analyze the factors affecting refractory chronic rhinosinusitis.
RESULTS: The Davos score, T&T olfactometer threshold test, and Lund-Mackay CT scores in refractory group were significantly higher than the chronic group (P<0.05). The level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α in the refractory group were significantly higher than the chronic group and the control group (all P<0.05). Similarly, the level of the above mentioned indexes in the chronic group were significantly higher than the control group (P<0.05). The Davos score, T&T olfactometer threshold test score, Lund-Mackay CT score, and the level of TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α positively correlated with refractory chronic rhinosinusitis. Moreover, the unconditional multivariate binary logistic regression showed that the influencing factors of refractory chronic rhinosinusitis included TGF-β1, MMP-9, TIMP-1, IL-1, IL-4, IL-6, IL-17, and TNF-α.
CONCLUSIONS: The findings of the present
study provide evidence for TGF-β1, MMP-9, TIMP-1, IL-4, IL-6, IL-17, and TNF-α as the influencing factors of refractory chronic rhinosinusitis.