■虚弱与精神疾病(MI)观察性研究有关,但是这些因素之间的因果关系仍然不确定。我们旨在通过双样本孟德尔随机化(MR)分析评估虚弱与MI之间的双向因果关系。
■为了研究它们之间的因果关系,虚弱指数(FI)和六种类型的MI的汇总统计:焦虑,抑郁症,情感障碍,躁狂症,精神分裂症,和强迫症(OCD)纳入这项MR研究。该MR分析使用方差逆加权(IVW)进行,MR-Egger回归,和加权中位数。结果的稳定性使用Cochran'sQ检验进行评估,MR-Egger截距测试,漏斗图,和遗漏分析。
■FI的遗传易感性与焦虑增加显着相关(比值比[OR]=1.62,95%置信区间[CI]1.13-2.33,P=8.18E-03),抑郁(OR=1.88,95%CI1.30-2.71,P=8.21E-04),情感障碍(OR=1.70,95%CI1.28-2.27,P=2.57E-04)。然而,我们的研究结果没有证明FI和躁狂症之间的因果关系(OR=1.02,95%CI0.99-1.06,P=2.20E-01),精神分裂症(OR=1.02,95%CI0.07-0.86,P=9.28E-01)。特别是,尽管IVW结果表明FI和OCD之间存在潜在的因果关系(OR=0.64,95%CI0.07-0.86,P=2.85E-02),从我们采用的三种方法获得的方向最终显示出不一致。因此,必须谨慎解释结果。反向MR分析结果表明焦虑之间存在统计学意义和因果关系(OR=1.06,95%CI1.01-1.11,P=2.00E-02),抑郁(OR=1.14,95%CI1.04-1.26,P=7.99E-03),情感障碍(OR=1.15,95%CI1.09-1.21,P=3.39E-07),和精神分裂症(OR=1.02,95%CI1.01-1.04,P=1.70E-03)的FI。然而,我们的研究结果不支持躁狂症之间的联系(OR=1.46,95%CI0.79-2.72,P=2.27E-01),OCD(OR=1.01,95%CI1.00-1.02,P=2.11E-01)和FI风险增加。
■MR结果表明,FI和焦虑之间存在潜在的双向因果关系,抑郁症,和情感障碍。发现精神分裂症与较高的FI风险相关。该证据不足以支持Fl与其他Ml之间的因果关系。这些发现为制定针对脆弱和MI的有效管理策略提供了新的见解。
UNASSIGNED: Frailty has been associated with mental illness (MI) observational studies, but the causal relationship between these factors remains uncertain. We aimed to assess the bidirectional causality between frailty and MI by two-sample Mendelian randomization (MR) analyses.
UNASSIGNED: To investigate the causal relationship among them, summary statistics of frailty index (FI) and six types of MI: anxiety, depression, affective disorder, mania, schizophrenia, and obsessive-compulsive disorder (OCD) were included in this MR
study. This MR analysis was performed using inverse variance weighting (IVW), MR-Egger regression, and weighted median. The stability of the results was evaluated using Cochran\'s Q test, MR-Egger intercept test, Funnel Plots, and leave-one-out analysis.
UNASSIGNED: Genetic predisposition to FI was significantly associated with increased anxiety (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.13-2.33, P = 8.18E-03), depression (OR = 1.88, 95% CI 1.30-2.71, P = 8.21E-04), affective disorder (OR = 1.70, 95% CI 1.28-2.27, P = 2.57E-04). However, our
study findings do not demonstrate a causal relationship between FI and mania (OR = 1.02, 95% CI 0.99-1.06, P = 2.20E-01), schizophrenia (OR = 1.02, 95% CI 0.07-0.86, P = 9.28E-01). In particular, although the IVW results suggest a potential causal relationship between FI and OCD (OR = 0.64, 95% CI 0.07-0.86, P = 2.85E-02), the directions obtained from the three methods we employed ultimately show inconsistency. Therefore, the result must be interpreted with caution. The results of the reverse MR analysis indicated a statistically significant and causal relationship between anxiety (OR = 1.06, 95% CI 1.01-1.11, P = 2.00E-02), depression (OR = 1.14, 95% CI 1.04-1.26, P = 7.99E-03), affective disorder (OR = 1.15, 95% CI 1.09-1.21, P = 3.39E-07), and schizophrenia (OR = 1.02, 95% CI 1.01-1.04, P = 1.70E-03) with FI. However, our findings do not provide support for a link between mania (OR = 1.46, 95% CI 0.79-2.72, P = 2.27E-01), OCD (OR = 1.01, 95% CI 1.00-1.02, P = 2.11E-01) and an increased risk of FI.
UNASSIGNED: The MR results suggest a potential bidirectional causal relationship between FI and anxiety, depression, and affective disorder. Schizophrenia was found to be associated with a higher risk of FI. The evidence was insufficient to support a causal relationship between Fl and other Ml. These findings offer new insights into the development of effective management strategies for frailty and MI.