PDF(Pubmed)
Abstract：
UNASSIGNED: The risk of venous thromboembolism in patients with mental illness has been insufficiently addressed. This study aimed to assess the correlation between hyperhomocysteinemia and venous thromboembolism prevalence among this population.
UNASSIGNED: Patients with a diagnosis of mental illness and concurrent venous thromboembolism, admitted to Sir Run Run Shaw Hospital at Zhejiang University School of Medicine between January 2014 and December 2021, were included in the venous thromboembolism group. The control group, approximately twice the size, comprised individuals with mental illness but without venous thromboembolism. Basic clinical data were gathered for both cohorts.
UNASSIGNED: In psychiatric patients, elevated D-dimer levels(OR=5.60,95% CI 3.28-10.00), hyperhomocysteinemia (OR=2.37,95% CI 1.10-5.14), and hyperprolactinemia(OR= 2.68,95% CI 1.12-6.42)were significant risk factors for venous thromboembolism. According to further subgroup analyses, hyperhomocysteinemia is a significant risk factor associated with pulmonary embolism, with an OR of 5.08 (95% CI 1.20-21.48). An interaction effect between gender and homocysteine level was found, with a p-interaction of 0.022. A subsequent analysis confirmed the association between hyperhomocysteinemia and venous thromboembolism in female psychiatric patients, with an OR of 3.34 (95% CI 1.68-6.65), indicating that hyperhomocysteinemia is a significant risk factor for venous thromboembolism in women.
UNASSIGNED: Patients with psychiatric disorders were found to have an elevated risk of venous thromboembolism, which was associated with increased levels of D-dimer, hyperprolactinemia, and hyperhomocysteinemia. A strong correlation between hyperhomocysteinemia and pulmonary embolism was identified in patients with mental illnesses. Furthermore, the study revealed that female psychiatric patients with hyperhomocysteinemia constituted a high-risk group for venous thromboembolism. This finding holds significant clinical implications, suggesting that early preventative measures could be implemented for this high-risk population to reduce the incidence of thromboembolic events during hospitalization for psychiatric patients.
UNASSIGNED: Patients with a diagnosis of mental illness and concurrent venous thromboembolism, admitted to Sir Run Run Shaw Hospital at Zhejiang University School of Medicine between January 2014 and December 2021, were included in the venous thromboembolism group. The control group, approximately twice the size, comprised individuals with mental illness but without venous thromboembolism. Basic clinical data were gathered for both cohorts.
UNASSIGNED: In psychiatric patients, elevated D-dimer levels(OR=5.60,95% CI 3.28-10.00), hyperhomocysteinemia (OR=2.37,95% CI 1.10-5.14), and hyperprolactinemia(OR= 2.68,95% CI 1.12-6.42)were significant risk factors for venous thromboembolism. According to further subgroup analyses, hyperhomocysteinemia is a significant risk factor associated with pulmonary embolism, with an OR of 5.08 (95% CI 1.20-21.48). An interaction effect between gender and homocysteine level was found, with a p-interaction of 0.022. A subsequent analysis confirmed the association between hyperhomocysteinemia and venous thromboembolism in female psychiatric patients, with an OR of 3.34 (95% CI 1.68-6.65), indicating that hyperhomocysteinemia is a significant risk factor for venous thromboembolism in women.
UNASSIGNED: Patients with psychiatric disorders were found to have an elevated risk of venous thromboembolism, which was associated with increased levels of D-dimer, hyperprolactinemia, and hyperhomocysteinemia. A strong correlation between hyperhomocysteinemia and pulmonary embolism was identified in patients with mental illnesses. Furthermore, the study revealed that female psychiatric patients with hyperhomocysteinemia constituted a high-risk group for venous thromboembolism. This finding holds significant clinical implications, suggesting that early preventative measures could be implemented for this high-risk population to reduce the incidence of thromboembolic events during hospitalization for psychiatric patients.
摘要：
■精神疾病患者的静脉血栓栓塞风险尚未得到充分解决。本研究旨在评估该人群中高同型半胱氨酸血症与静脉血栓栓塞患病率之间的相关性。
■诊断为精神疾病并并发静脉血栓栓塞的患者，2014年1月至2021年12月期间入住浙江大学医学院附属邵逸夫医院，纳入静脉血栓栓塞组。对照组,大约两倍的大小，包括患有精神疾病但没有静脉血栓栓塞的个体。收集两个队列的基本临床数据。
■在精神病患者中，D-二聚体水平升高（OR=5.60,95%CI3.28-10.00），高同型半胱氨酸血症（OR=2.37,95%CI1.10-5.14），高泌乳素血症(OR=2.68,95%CI1.12～6.42)是静脉血栓栓塞的重要危险因素。根据进一步的亚组分析，高同型半胱氨酸血症是肺栓塞的重要危险因素,OR为5.08（95%CI1.20-21.48）。发现性别与同型半胱氨酸水平之间存在交互作用，p相互作用为0.022。随后的分析证实了女性精神病患者高同型半胱氨酸血症和静脉血栓栓塞之间的关联。OR为3.34（95%CI1.68-6.65），表明高同型半胱氨酸血症是女性静脉血栓栓塞的重要危险因素。
患有精神疾病的患者静脉血栓栓塞的风险升高，这与D-二聚体水平升高有关，高催乳素血症,高同型半胱氨酸血症.在患有精神疾病的患者中，高同型半胱氨酸血症与肺栓塞之间存在很强的相关性。此外，研究显示,患有高同型半胱氨酸血症的女性精神病患者是静脉血栓栓塞症的高危人群.这一发现具有重要的临床意义，提示可对该高危人群实施早期预防措施,以降低精神病患者住院期间血栓栓塞事件的发生率.
■诊断为精神疾病并并发静脉血栓栓塞的患者，2014年1月至2021年12月期间入住浙江大学医学院附属邵逸夫医院，纳入静脉血栓栓塞组。对照组,大约两倍的大小，包括患有精神疾病但没有静脉血栓栓塞的个体。收集两个队列的基本临床数据。
■在精神病患者中，D-二聚体水平升高（OR=5.60,95%CI3.28-10.00），高同型半胱氨酸血症（OR=2.37,95%CI1.10-5.14），高泌乳素血症(OR=2.68,95%CI1.12～6.42)是静脉血栓栓塞的重要危险因素。根据进一步的亚组分析，高同型半胱氨酸血症是肺栓塞的重要危险因素,OR为5.08（95%CI1.20-21.48）。发现性别与同型半胱氨酸水平之间存在交互作用，p相互作用为0.022。随后的分析证实了女性精神病患者高同型半胱氨酸血症和静脉血栓栓塞之间的关联。OR为3.34（95%CI1.68-6.65），表明高同型半胱氨酸血症是女性静脉血栓栓塞的重要危险因素。
患有精神疾病的患者静脉血栓栓塞的风险升高，这与D-二聚体水平升高有关，高催乳素血症,高同型半胱氨酸血症.在患有精神疾病的患者中，高同型半胱氨酸血症与肺栓塞之间存在很强的相关性。此外，研究显示,患有高同型半胱氨酸血症的女性精神病患者是静脉血栓栓塞症的高危人群.这一发现具有重要的临床意义，提示可对该高危人群实施早期预防措施,以降低精神病患者住院期间血栓栓塞事件的发生率.
