癌症的特征在于引起细胞过度增殖和信号通路过度活化的改变。信号分子的变化失调的生理功能,如细胞生长,扩散,转移,细胞死亡。因此,潜在的抗癌化合物主要针对信号网络,用于癌症的治疗干预。在过去的几年里,癌症治疗将重点放在源自海洋来源的生物活性化合物上,考虑到它们的多样性和未开发的性质。这些海洋生物活性化合物(MBC)大致分为不同的类别,如生物碱,碳水化合物,脂肪酸,肽,酚类物质,醌,萜烯,和皂苷。来自每一类的生物活性化合物通过不同的信号通路引发细胞死亡。这篇综述的主要目的是通过整合来自几个海洋抗癌研究的数据,提供有关每一类MBC主要遵循的途径的全面信息。这里,我们研究了每一类MBC所遵循的信号网络,以抑制各种癌症类型.因此,我们的结论是PI3K/AKT,ROS,p53是由MBCs靶向诱导癌细胞凋亡的三种主要信号通路,这些通路主要在碳水化合物等类别中观察到,肽,和萜烯。因此,可以得出结论,未来的抗癌研究可以主要集中在来自经过审查的类别的MBC上,这些类别遵循PI3K/AKT等途径。ROS,和p53实现卓越的结果。
Cancer is characterized by alterations that cause the over-proliferation of cells and hyperactivation of signaling pathways. Alterations of signaling molecules dysregulate physiological functions like cell growth, proliferation, metastasis, and cell death. Hence, the potential anticancer compounds primarily target signaling networks for therapeutic interventions in cancer. In the past few years, cancer therapy directed its focus on bioactive compounds that originated from marine sources considering their diverse and untapped nature. These Marine Bioactive Compounds (MBCs) are broadly classified into distinct categories such as alkaloids, carbohydrates, fatty acids, peptides, phenols, quinones, terpenes, and saponins. Bioactive compounds from each class initiate cell death via different signaling pathways. The primary objective of this
review is to provide comprehensive information about the pathways that are predominantly followed by every class of MBCs by integrating data from several marine anticancer research. Here, we studied the signaling networks followed by each class of MBCs to inhibit various cancer types. As a result, we concluded that PI3K/AKT, ROS, and p53 are the three major signaling pathways targeted by the MBCs to induce apoptosis in cancer cells and these pathways are predominantly observed in classes like carbohydrates, peptides, and terpenes. Hence it is concluded that future anticancer research can be primarily focused on the MBCs derived from the scrutinized classes that adhere to pathways like PI3K/AKT, ROS, and p53 to achieve par excellence results.