利什曼病作为一种普遍被忽视的媒介传播的原生动物疾病,在流行地区是一个主要的公共卫生问题,因为全世界有1200万人受到影响,每年有60,000人死亡。使用当前化学疗法中的一些问题和副作用导致对抗利什曼病的新药物递送系统的发展。例如,层状双氢氧化物(LDHs)由于其适当的特性而被称为阴离子粘土,最近考虑过。在本研究中,采用共沉淀法制备LDH纳米载体。然后,两性霉素B的嵌入反应通过间接离子交换试验进行.最后,在表征制备的LDHs后,使用体外和计算机模型评估了Amp-Zn/Al-LDH纳米复合材料对主要利什曼原虫的抗利什曼原虫作用。根据结果,目前的研究表明,Zn/Al-NO3LDH纳米载体可以作为一种新的有前途的递送系统,通过将两性霉素B插入到其夹层空间中,通过显着的免疫调节消除L.主要寄生虫来治疗利什曼病,抗氧化和凋亡作用。
Leishmaniasis as a widespread neglected vector-borne protozoan disease is a major public health concern in endemic areas due to 12 million people affected worldwide and 60,000 deaths annually. Several problems and side effects in using current chemotherapies leads to progression of new drug delivery systems against leishmaniasis. For instance, layered double hydroxides (LDHs) so-called anionic clays due to their proper characteristics, have been considered recently. In the present
study, LDH nanocarriers were prepared using co-precipitation method. Then, the intercalation reactions with amphotericin B were conducted via indirect ion exchange assay. Finally, after characterization of prepared LDHs, the anti-leishmanial effects of Amp-Zn/Al-LDH nanocomposites against Leishmania major were evaluated using an in vitro and in silico model. According to results, current
study demonstrated that Zn/Al-NO3 LDH nanocarriers can be used as a new promising delivery system by intercalating amphotericin B into its interlayer space for leishmaniasis treatment by eliminating the L. major parasites by remarkable immunomodulatory, antioxidant and apoptotic effects.