目的:这项多中心研究旨在评估非综合征和综合征性牙源性角化囊肿的病例,以及这两组内的复发病例。
方法:这是描述性的,分析,回顾性横断面研究评估了性别,在10个巴西口腔和颌面病理中心看到的1,169例患者的年龄和多发性病变的存在。其中,1,341例牙源性角化囊肿的临床诊断分析,尺寸,site,成像外观,症状和体征,活检类型,治疗,和复发。
结果:性别分布相似。非综合征和综合征患者的中位年龄为32岁和17.5岁,分别。在两组和复发病例中,下颌骨后部是受小病变和大病变影响最大的部位。单眼病变更频繁,在复发病例中也是如此。主要是小病灶表现为这种影像学表现。在大多数情况下没有体征和症状。保守治疗是所有年龄组中最常见的治疗方式,无论患者的病情和复发。复发并不常见。
结论:本研究显示人群中出现非综合征性角化囊肿的频率较高。涉及多个部位的临床病理特征,年龄,复发可能在综合征和非综合征病例之间有所不同。此外,我们发现病变大小与某些临床特征之间以及复发时间间隔与综合征谱之间存在关联.
结论:为了有助于更好地理解临床,成像,和社会人口统计学特征在每个范围的病变。
OBJECTIVE: This multicenter
study aimed to evaluate cases of non-syndrome and syndromic odontogenic
keratocyst, as well as cases of recurrence within these two groups.
METHODS: This descriptive, analytical, retrospective cross-sectional
study evaluated the sex, age and presence of multiple lesions in 1,169 individuals seen at 10 Brazilian oral and maxillofacial pathology centers. Of these, 1,341 odontogenic keratocysts were analyzed regarding clinical diagnosis, size, site, imaging appearance, signs and symptoms, type of biopsy, treatment, and recurrence.
RESULTS: There was a similar distribution by sex. The median age of non-syndromic and syndromic patients was 32 and 17.5 years, respectively. The posterior mandible was the site most affected by small and large lesions in both groups and in recurrent cases. Unilocular lesions were more frequent, also in recurrent cases. Mainly small lesions showed this imaging appearance. Signs and symptoms were absent in most cases. Conservative treatment was the most frequent modality in all age groups, regardless of the patient\'s condition and recurrence. Recurrences were uncommon.
CONCLUSIONS: This
study showed a higher frequency of non-syndromic keratocysts in the population. Clinicopathological features related to the involvement of multiple sites, age, and recurrence may differ between syndromic and non-syndromic cases. Furthermore, we found an association between lesion size and some clinical features and between the time interval to recurrence and the syndromic spectrum.
CONCLUSIONS: To contribute to a better understanding of the distribution and association between clinical, imaging, and sociodemographic characteristics in each spectrum of the lesion.