Abstract：
The high recurrence rate of odontogenic keratocysts (OKC) entails a large number of follow-up interventions after primary surgery. This study aimed to compare recurrent with primary OKC in regard to recurrence rate, treatment modality, radiographic and clinical findings. A single center retrospective cohort study with surgically treated OKC between 2012 and 2021 was conducted. The primary predictor was recurrence type of the lesion: primary (P-OKC), first recurrence (R1-OKC) and second recurrence (R2-OKC). The primary outcome variables were recurrence and time to recurrence. 68 surgeries were identified. Recurrence was not significantly associated with recurrence type (p = 0.906) but with the method of surgery (p < 0.001). Marsupialized R1-OKC recurred earlier than marsupialized P-OKC. Diameter was significantly associated with recurrence type (p = 0.002). R1-OKC had a smaller median diameter than P-OKC and R2-OKC were smaller than R1-and P-OKC. P-OKC were associated with teeth in 79% of surgeries, R1-OKC in 61% and R2-OKC in 27% (p = 0.007). Postoperative numbness was present after 40% of surgeries and decreased to 15% at follow-up, independently of recurrence type. Time to recurrence may be shorter for recurrent marsupialized OKC. Recurrent OKC are smaller and less often associated with teeth. Postoperative numbness after OKC surgery has a good prognosis.
摘要：
牙源性角化囊肿（OKC）的高复发率需要在初次手术后进行大量的随访干预。本研究旨在比较复发性OKC与原发性OKC的复发率，治疗方式，影像学和临床表现。在2012年至2021年之间进行了手术治疗OKC的单中心回顾性队列研究。主要预测因素是病变的复发类型：原发性（P-OKC），首次复发（R1-OKC）和第二次复发（R2-OKC）。主要结果变量是复发和复发时间。确认了68例手术。复发与复发类型无关（p=0.906），但与手术方法有关（p<0.001）。有袋化R1-OKC比有袋化P-OKC更早复发。直径与复发类型显著相关(p=0.002)。R1-OKC的中值直径小于P-OKC,R2-OKC小于R1-和P-OKC。在79%的手术中，P-OKC与牙齿相关，R1-OKC为61%,R2-OKC为27%(p=0.007)。40％的手术后出现术后麻木，随访时降至15％，独立于复发类型。复发性有袋OKC的复发时间可能较短。复发性OKC较小，并且与牙齿相关的频率较低。OKC术后麻木预后较好。
