{Reference Type}: Multicenter Study
{Title}: Sociodemographic and clinical characterization of cases of 1,103 non-syndromic and 66 syndromic odontogenic keratocyst: a Brazilian multicenter study.
{Author}: Pereira Santana DC;Abbehusen Couto L;de Santana Passos-Soares J;Caló de Aquino Xavier F;Alves Mesquita R;Aragão Felix F;da Silva TA;Weege Nonaka CF;Muniz Alves P;Rodrigues Ferreira C;Libório-Kimura TN;Castro de Oliveira Moreira L;Câmara J;Alfaia Silva C;de Mendonça EF;do Lago Costa N;Rebelo Pontes HA;Lacerda de Souza L;Freire de Castro Lisboa J;Pina Godoy G;Azevedo Lins de Holanda L;Domingues Martins M;Varvaki Rados P;Schmidt TR;de Almeida Freitas R;Batista de Souza L;Freitas de Morais E;Vargas PA;Ajudarte Lopes M;Alves Quixabeira Oliveira G;Nunes Dos Santos J;Gomes Henriques ÁC;
{Journal}: Clin Oral Investig
{Volume}: 27
{Issue}: 11
{Year}: 2023 Nov 19
{Factor}: 3.606
{DOI}: 10.1007/s00784-023-05313-7
{Abstract}: <B>OBJECTIVE: </B>This multicenter study aimed to evaluate cases of non-syndrome and syndromic odontogenic keratocyst, as well as cases of recurrence within these two groups.<BR><B>METHODS: </B>This descriptive, analytical, retrospective cross-sectional study evaluated the sex, age and presence of multiple lesions in 1,169 individuals seen at 10 Brazilian oral and maxillofacial pathology centers. Of these, 1,341 odontogenic keratocysts were analyzed regarding clinical diagnosis, size, site, imaging appearance, signs and symptoms, type of biopsy, treatment, and recurrence.<BR><B>RESULTS: </B>There was a similar distribution by sex. The median age of non-syndromic and syndromic patients was 32 and 17.5 years, respectively. The posterior mandible was the site most affected by small and large lesions in both groups and in recurrent cases. Unilocular lesions were more frequent, also in recurrent cases. Mainly small lesions showed this imaging appearance. Signs and symptoms were absent in most cases. Conservative treatment was the most frequent modality in all age groups, regardless of the patient's condition and recurrence. Recurrences were uncommon.<BR><B>CONCLUSIONS: </B>This study showed a higher frequency of non-syndromic keratocysts in the population. Clinicopathological features related to the involvement of multiple sites, age, and recurrence may differ between syndromic and non-syndromic cases. Furthermore, we found an association between lesion size and some clinical features and between the time interval to recurrence and the syndromic spectrum.<BR><B>CONCLUSIONS: </B>To contribute to a better understanding of the distribution and association between clinical, imaging, and sociodemographic characteristics in each spectrum of the lesion.