单吻合套管空肠(SASJ)旁路术是一种减肥手术技术,具有良好的效果。然而,目前仍缺乏其有效性和安全性的证据.本研究旨在总结SASJ搭桥手术治疗病态肥胖的有效性和安全性的证据。从开始到2023年11月26日,在MEDLINE/PubMed上搜索了这些文献中的英语研究,科克伦图书馆,WebofScience,ProQuest,Scopus,SCINAPSE,谷歌学者。搜索词包括“病态肥胖,“\”减肥手术,“和”单吻合套管空肠旁路术。“提取的数据包括手术前后的体重指数(BMI),总重量损失百分比(%TWL),过量体重减轻百分比(%EWL),和术前合并症的改善。基于显著异质性的存在,使用随机效应或固定效应模型进行数据汇集。本系统综述和荟萃分析包括9项研究。SASJ旁路手术后12个月,BMI相对于基线的变化显着(标准化平均差(SMD)=-3.576,95%置信区间(CI)=-5.423,-1.730;I²=99.23%)。手术后12个月,合并的TWL百分比为42.526(95%CI=37.948,47.105;I²=97.15%),合并的EWL百分比为75.258(95%CI=67.061,83.456;I²=99.26%)。糖尿病术后改善的合并发生率为91%(95%CI=79.6%,98%,I²=82%)。并发症的总发生率为9.9%(95%CI=2.5%,21.6%;I²=92.64%)。关于短期和中期结果,SASJ旁路术是病态肥胖患者减肥的安全有效方法,并发症发生率可接受。该程序还与肥胖相关合并症的明显改善有关。
Single-anastomosis sleeve jejunal (SASJ) bypass is a bariatric surgery technique with promising results. However, evidence of its efficacy and safety is still lacking. This study aimed to summarize the evidence regarding the efficacy and safety of SASJ bypass surgery in the treatment of morbid obesity. The literature was searched for English-language studies published from inception till November 26, 2023, on MEDLINE/PubMed, Cochrane Library, Web of Science, ProQuest, Scopus, SCINAPSE, and Google Scholar. The search terms included \"morbid obesity,\" \"bariatric surgery,\" and \"single anastomosis sleeve jejunal bypass.\" Extracted data included the body mass index (BMI) before and after surgery, percent total weight loss (%TWL), percent excess weight loss (%EWL), and improvement in preoperative comorbidities. Pooling of the data was done using random effects or fixed-effect models based on the presence of significant heterogeneity. Nine studies were included in this systematic
review and meta-analysis. The change in BMI from baseline at 12 months after SASJ bypass was significant (standardized mean difference (SMD) = -3.576, 95% confidence interval (CI) = -5.423, -1.730; I² = 99.23%). At 12 months after surgery, the pooled %TWL was 42.526 (95% CI = 37.948, 47.105; I² = 97.15%), and the pooled %EWL was 75.258 (95% CI = 67.061, 83.456; I² = 99.26%). The pooled incidence of postoperative improvement in diabetes mellitus was 91% (95% CI = 79.6%, 98%, I² = 82%). The overall rate of complications was 9.9% (95% CI = 2.5%, 21.6%; I² = 92.64%). Regarding the short- and mid-term outcomes, SASJ bypass is a safe and effective procedure for weight loss in patients with morbid obesity, with an acceptable rate of complications. The procedure is also associated with a marked improvement in obesity-related comorbidities.