目的:血清神经丝轻链(sNfL)可以反映神经损伤。偏头痛是否会引起神经损伤尚不清楚。这项研究评估了偏头痛患者的sNfL水平,并探讨了偏头痛是否存在神经损伤。
方法:在厦门进行了病例对照研究,中国。总共招募了138名偏头痛患者和70名健康对照。在单分子阵列平台上测量sNfL(pg/mL)。单变量,采用Pearson相关和线性回归分析评价偏头痛与sNfL水平的关系,通过偏头痛特征进行进一步的亚组分析。
结果:总体而言,208名受试者中85.10%为女性,平均年龄为36岁。偏头痛组的sNfL水平高于对照组(4.85(3.49,6.62)4.11(3.22,5.59)),但差异无统计学意义(P=0.133)。两组显示出几乎一致的趋势,其中sNfL水平随着年龄的增长而显着增加。亚组分析显示,偏头痛病程≥10年的患者sNfL水平显着增加(β=0.693(0.168,1.220),P=0.010)。回归分析结果显示,年龄和偏头痛病程是sNfL水平升高的独立危险因素,这两个因素之间存在相互作用。年龄<45岁且偏头痛病程≥10年的患者sNfL水平显着增加。
结论:这是第一个评估偏头痛患者sNfL水平的研究。偏头痛病程≥10年的患者sNfL水平显着增加。对于长期偏头痛的年轻患者,需要更多地关注神经损伤。
OBJECTIVE: Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine.
METHODS: A
case-control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics.
RESULTS: Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels.
CONCLUSIONS: This is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required.