■许多研究表明,ω-3脂肪酸可能在心血管疾病中起关键作用。心肌梗塞(MI)通常由冠状动脉的血栓阻塞导致心肌缺血。因此,本研究旨在探讨omega-3脂肪酸与MI之间的关系.
■一项双样本孟德尔随机研究用于探索循环omega-3脂肪酸与通过MR-Egger回归进行的MI风险之间的因果关系,逆方差加权(IVW),加权中位数,和加权模式。
■从已发表的全基因组关联研究(GWAS)荟萃分析中选择了与循环中的omega-3脂肪酸强相关的五个单核苷酸多态性作为工具变量,包括13,544名受试者。我们从另一个GWAS荟萃分析中提取了MI风险的汇总数据,包括171,875名个体(43,676例和128,199例对照)。IVW结果显示,遗传预测的低循环omega-3增加了心肌梗死的风险[比值比(OR)=1.224,95%CI=1.045-1.433,P=0.012],加权中位数法(OR=1.171,95%CI=1.042-1.315,P=0.008),和加权模式(OR=1.149,95%CI=1.002-1.317,P=0.117),尽管MR-Egger的结果不显着(OR=0.950,95%CI=0.513-1.760,P=0.880),置信区间更宽。
■孟德尔随机化分析的结果表明,omega-3脂肪酸水平与MI之间的关联可能是因果关系。
UNASSIGNED: Many studies have shown that omega-3 fatty acids may play critical roles in cardiovascular diseases. Myocardial infarction (MI) typically results from a thrombotic occlusion of a coronary artery leading to myocardial ischemia. Thus, this
study aims to examine the association between omega-3 fatty acids and MI.
UNASSIGNED: A two-sample Mendelian randomization
study was used to explore the causal relationship between circulating omega-3 fatty acids and the risk of MI performed by MR-Egger regression, inverse-variance weighted (IVW), weighted median, and weighted mode.
UNASSIGNED: Five single-nucleotide polymorphisms strongly related to circulating omega-3 fatty acids were selected as instrumental variables from a published genome-wide association
study (GWAS) meta-analysis including 13,544 subjects. We extracted summary data for the risk of MI from another GWAS meta-analysis including 171,875 individuals (43,676 cases and 128,199 controls). The genetically predicted lower circulating omega-3 increased the risk of myocardial infarction showed by the results of IVW [odds ratio (OR) = 1.224, 95% CI = 1.045-1.433, P = 0.012], weighted median method (OR = 1.171, 95% CI = 1.042-1.315, P = 0.008), and weighted mode (OR = 1.149, 95% CI = 1.002-1.317, P = 0.117), although the result of MR-Egger was not significant (OR = 0.950, 95% CI = 0.513-1.760, P = 0.880) with a wider confidence interval.
UNASSIGNED: The findings from our Mendelian randomization analysis suggest that the association between omega-3 fatty acid levels and MI is likely causal.