infected

已感染
  • 文章类型: Journal Article
    霉菌性锁骨下动脉动脉瘤(SAAs)是一种非常罕见的疾病。
    为了概述有关临床特征的最新知识,霉菌性SAA的管理策略和结果评估。
    研究材料基于对2000年至2023年之间发表的真菌SAA出版物的全面文献检索。
    受污染的机械损伤和动脉壁的脓肿侵蚀是霉菌性SAA的机制。诊断依赖于通过血液的培养或微生物学研究来检测病原微生物,其他液体和感染组织以及医学成像可视化。介入治疗的适应症是一般情况较差,手术风险高,以及假性动脉瘤破裂的救援排除。三例(9.1%)治疗前死亡是由于霉菌性SAA突然破裂所致,因此他们失去了治疗机会。所有治疗后死亡均发生在介入患者组中,而死亡原因似乎与霉菌性SAA本身或选择的治疗无关。患者预后评估显示,选择的不同治疗方法之间没有显着差异。没有显著的预测风险因素对患者预后负责。
    一旦诊断为霉菌性SAA,立即应用敏感抗菌药物控制感染和动脉瘤进展。尽早进行治疗以避免动脉瘤破裂。根据患者的具体情况决定选择治疗方法。在手术或介入治疗后持续使用抗菌药物约6周。
    UNASSIGNED: Mycotic subclavian artery aneurysms (SAAs) are a very rare disorder.
    UNASSIGNED: To provide an overview of current knowledge on clinical features, management strategies and outcome evaluations of mycotic SAAs.
    UNASSIGNED: The study materials were based on comprehensive literature retrieval of publications of mycotic SAAs published between 2000 and 2023.
    UNASSIGNED: Contaminated mechanical injuries and abscess erosions of the arterial walls are mechanisms of mycotic SAAs. The diagnosis relies on detection of pathogenic microorganisms by cultures or microbiological investigations of blood, other fluids and infected tissues as well as medical imaging visualization. The indications for an interventional therapy were poor general condition, high surgical risk, and rescue exclusion for a ruptured pseudoaneurysm. Three (9.1%) pre-treatment deaths were a result of sudden rupture of the mycotic SAAs and thus they lost the opportunity of treatment. All post-treatment deaths occurred in the interventional patient group, whereas the causes of death seemed to be unrelated to mycotic SAAs per se or to treatments of choice. Patient outcome evaluations revealed no significant difference between different treatments of choice. No significant predictive risk factors were responsible for patient outcomes.
    UNASSIGNED: Once a diagnosis of mycotic SAA is made, sensitive antibacterial drugs are applied immediately to control the infection and control aneurysmal progression. Early treatment is conducted as soon as possible to avoid aneurysmal rupture. A decision on treatment of choice is made based on the patient\'s specific condition. Antibacterial drug use is continued for about 6 weeks after surgical or interventional therapy.
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  • 文章类型: Case Reports
    背景:在儿科人群中从未描述过感染的pop动脉假性动脉瘤。医生需要意识到它的呈现和管理,为了充分诊断和治疗这种疾病。
    方法:我们描述了一个14岁男孩的案例,他在打篮球后出现了以po窝为中心的肌炎和蜂窝织炎。开始静脉内治疗头孢唑啉。5天后,他经历了膝盖疼痛发作,结果是一种伴pop动脉假性动脉瘤的pop化脓性肌炎。对pop动脉进行了隐静脉移植旁路,并切除了pop假性动脉瘤。连续静脉注射头孢唑林6周,预防性使用乙酰水杨酸6个月。
    结论:该病例强调,如果软组织感染患者在使用适当的抗生素几天后出现持续性疼痛,则重复进行放射学检查的重要性。pop假性动脉瘤可以通过超声成像诊断,并通过pop-pop旁路治疗。我们的病人需要在手术后6个月的静脉移植物处进行导管引导的吻合术扩张,然后发展良好,并在扩张后6个月回到打篮球。
    BACKGROUND: An infected popliteal pseudoaneurysm has never been described in the pediatric population. Physicians need to be aware of its presentation and management, in order to diagnose and treat this medical condition adequately.
    METHODS: We describe the case of a 14-year-old boy who developed myositis and cellulitis centered at the popliteal fossa after playing basketball. A treatment of intravenous cefazolin was started. 5 days later, he experienced a knee pain flare-up, which turned out to be a popliteal pyomyositis with a pseudoaneurysm of the popliteal artery. A saphenous vein graft bypass of the popliteal artery and an excision of the popliteal pseudoaneurysm were performed. Intravenous cefazolin was continued for 6 weeks and prophylactic acetylsalicylic acid for 6 months.
    CONCLUSIONS: This case highlighted the importance of repeating radiologic investigations if a patient suffering from soft tissue infection has persistent pain after several days of appropriate antibiotics. A popliteal pseudoaneurysm can be diagnosed with ultrasound imaging and treated with a popliteal-popliteal bypass. Our patient needed a catheter-guided dilation of the anastomosis at the vein graft 6 months post-surgery, and then evolved favorably and went back to playing basketball 6 months post-dilation.
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  • 文章类型: Journal Article
    OBJECTIVE: Controversy has continued regarding the use of endovascular aneurysm repair (EVAR) vs open aneurysm repair (OAR) for infected abdominal aortic aneurysms (AAAs). In the present study, we investigated the comparative outcomes of EVAR and OAR for the treatment of infected AAAs.
    METHODS: We conducted a systematic review and meta-analysis using the MEDLINE and EMBASE databases through May 2021. We included studies that had described both EVAR and OAR for the treatment of infected AAAs. The primary endpoints were the rates of recurrent infection and related rupture and/or death. Perioperative and 1-year mortality and readmissions and reinterventions were also analyzed.
    RESULTS: Fourteen observational studies describing a total of 1203 patients (EVAR, 359 [29.8%]; OAR, 844 [70.2%]) were eligible for qualitative analysis. The baseline characteristics included diabetes mellitus (33.2%), fever at presentation (71.6%), rupture at diagnosis (26.1%), and positive blood cultures (52.5%). The mean follow-up period ranged from 12 to 40 months. The use of EVAR became more prevalent in recent years (2016-2020, 32.4%) compared with the former period (2010-2015, 13.8%; P < .0001). Fenestrated, branched, or concomitant visceral debranching EVAR was performed in 6.1% of cases. In OAR, surgical debridement was consistently performed, and in situ reconstruction was applied in 82.2% and an omental flap in 51.5%. In nine studies considered for quantitative analysis, the patients\' background (EVAR, n = 264; OAR, n = 274) were statistically balanced. The crude rates of recurrent infection and related rupture or death were 13.6% (95% confidence interval [CI], 8.8%-18.5%) and 4.9% (95% CI 1.8%-8.0%), respectively. The pooled analyses depicted significantly higher rates of recurrent infection after EVAR than after OAR (relative risk [RR], 2.42; 95% CI, 1.80-3.27; P < .0001; I2 = 0%). Recurrent infection-related rupture or death (RR, 1.51; 95% CI, 0.70-3.23; P = .29; I2 = 0%), perioperative death (RR, 0.80; 95% CI, 0.39-1.65; P = .55; I2 = 35%), 1-year mortality (hazard ratio, 1.12; 95% CI, 0.97-1.28; P =.13; I2 = 0%), and readmission or reintervention (RR, 1.16; 95% CI, 0.74-1.82; P =.52; I2 = 0%) were not significantly different statistically between the two groups. Funnel plots showed no evidence of publication bias. Sensitivity analyses of leave-one-out meta-analysis confirmed higher rates of recurrent infection after EVAR.
    CONCLUSIONS: EVAR has become more prevalent as the initial treatment of infected AAAs. Although operative and 1-year survival were similar between OAR and EVAR groups, recurrent infection was more frequent after EVAR. This limitation should be weighed in selecting patients for EVAR in infected AAAs. Postoperative graft and infection surveillance are critical, especially after EVAR.
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  • 文章类型: Journal Article
    Epidemic simulations have recently been used to model the dynamics of malicious codes in the network of wireless sensors. This is because of its open existence, which offers a simple target for malware attacks aimed at disrupting network operations or, worse, causing complete network failure. The Susceptible-Exposed-Infectious-Quarantined-Recovered-Susceptible with Vaccination compartments models like SIR-M, SEIRV, SEIQRV, SEIRS, SITR, SIR with delay are studied by various authors and some of such models that characterize worm dynamics in WSN. After a concise presentation of the wireless sensor network, some primary research consequences of e-pandemic models (of various researchers) are given and assessed. At that point the uses of wireless sensor network in the clinical wellbeing, agribusiness, and military, space and marine investigation are laid out. What\'s more, we break down the upside of wireless sensor network in these sectors. In this review article, we sum up the fundamental factors that influence the uses of wireless sensor networks in view of e-epidemic models and revived some epidemic models and also discussed some conceivable future works of different epidemic wireless sensor models.
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  • 文章类型: Journal Article
    OBJECTIVE: The aim of this systematic literature review was to compile an updated overview of mycotic aortic aneurysm (MAA) treatment and outcomes.
    METHODS: A systematic literature review was performed using the search terms mycotic and infected aortic aneurysms in the MEDLINE and ScienceDirect databases, published between January 2000 and September 2018. Using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, articles were scrutinised regarding surgical technique, aortic segment involved, pre- and post-operative antibiotic regimens, survival and infection related complications (IRCs), and factors associated with adverse or favourable outcomes.
    RESULTS: Twenty-eight studies, with a total of 963 patients, were included. All publications were observational, retrospective studies. Patient and study heterogeneity, along with missing data, precluded meta-analyses. Overall treatment consisted of open surgical repair (OSR; n = 556 [58%]), endovascular aortic repair (EVAR; n = 373 [39%]), and medical treatment alone (n = 34 [3%]). OSR was the dominant surgical technique prior to 2010, shifting to EVAR thereafter. For MAAs located in the abdominal aorta, EVAR was associated with better short term survival than OSR. Antibiotic treatment for more than six months post-operatively was associated with better survival, but there was no consensus on the length of treatment. MAAs were complicated by IRCs in 21%, irrespective of surgical technique, of which 46%-70% were fatal. The most consistently reported factors associated with adverse outcomes were increasing age, rupture, suprarenal abdominal aneurysm location, and non-Salmonella positive culture.
    CONCLUSIONS: With few exceptions, the literature mainly consists of small, retrospective single centre studies. Standardised reporting is needed to increase comparability of studies. EVAR appears to be associated with superior short term survival without late disadvantages, compared with OSR. This suggests that EVAR can be an acceptable alternative to OSR. However, MAA treatment should always be tailor made and planned individually, and general recommendations are in vain. IRCs pose a significant threat to patients after MAA repair and require further investigation.
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