炎症性肠病(IBD)是一种自身免疫性疾病,其特征是影响肠道的慢性炎症。克罗恩病(CD)和溃疡性结肠炎(UC)属于IBD保护伞,需要不同的治疗方法,包括类固醇,免疫调节剂如6-巯基嘌呤(6-MP)和硫唑嘌呤(AZA),和生物制剂。免疫调节剂的长期使用,比如AZA,与发展淋巴瘤的风险升高有关。此病例报告集中于一位77岁的绅士,定期进行胃肠病学监测,接受长期AZA治疗的CD管理。他出现了腭肿胀和慢性急性背痛,诊断为腭部滤泡性淋巴瘤伴转移。对于椎旁病变给予姑息性放疗,患者目前情况稳定。总之,这一病例强调了认识到肿瘤风险增加的重要性,尤其是淋巴瘤,在接受长期免疫调节剂治疗的患者中。它强调需要对病人护理采取警惕和全面的方法,超越传统范式。
Inflammatory bowel disease (IBD) is an autoimmune disorder marked by chronic inflammation affecting the intestines. Crohn\'s disease (CD) and ulcerative colitis (UC) fall under the IBD umbrella, necessitating diverse treatments, including steroids,
immunomodulators like 6-mercaptopurine (6-MP) and azathioprine (AZA), and biological agents. The prolonged use of
immunomodulators, such as AZA, is associated with an elevated risk of developing lymphomas. This
case report centers on a 77-year-old gentleman regularly monitored by Gastroenterology, undergoing long-term AZA therapy for CD management. He presented with palate swelling and acute-on-chronic back pain, diagnosed with follicular lymphoma in the palate with metastasis. Palliative radiotherapy was administered for the paraspinal lesion, and the patient is currently stable. In conclusion, this
case underscores the importance of recognizing the heightened risk of neoplasms, especially lymphomas, in patients undergoing prolonged immunomodulator therapy. It emphasizes the need for a vigilant and comprehensive approach to patient care, transcending conventional paradigms.